Overexpression of SerpinB9 in non-seminomatous germ cell tumors.

IF 1.2 4区医学 Q3 PATHOLOGY Medical Molecular Morphology Pub Date : 2024-03-01 Epub Date: 2023-11-22 DOI:10.1007/s00795-023-00374-9

Toshiki Anami, Yuki Ibe, Lianbo Li, Yoshihiro Komohara, Hiroki Hirao, Mamoru Harada, Hiromu Yano, Yukio Fujiwara, Takanobu Motoshima, Junji Yatsuda, Taizo Hibi, Tomomi Kamba

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Abstract

Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpressed in testicular embryonal carcinoma. Immunohistological analysis was performed on 28 cases of testicular germ cell tumors to investigate the relationship between SerpinB9 expression in testicular germ cell tumors and the tumor immune environment. SerpinB9 was significantly upregulated in the non-seminoma group and inversely correlated with the number of tumor-infiltrating CD8-positive cells. In addition, yolk sac tumors were characterized by the loss of human leukocyte antigen-class I expression. These findings suggest that SerpinB9 contributes to the immune escape of testicular germ cell tumors. Targeting therapy for SerpinB9 might therefore be useful in immunotherapy for testicular germ cell tumors resistant to immune checkpoint inhibitors.

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SerpinB9在非半细胞性生殖细胞肿瘤中的过表达。

Serpinb9是颗粒酶B的抑制剂，可能参与肿瘤细胞的免疫逃逸。在本研究中，利用开放数据库进行的生物信息学分析表明，SerpinB9在睾丸胚胎癌中过表达。对28例睾丸生殖细胞肿瘤进行免疫组织学分析，探讨SerpinB9在睾丸生殖细胞肿瘤中的表达与肿瘤免疫环境的关系。SerpinB9在非精原细胞瘤组中显著上调，且与肿瘤浸润的cd8阳性细胞数量呈负相关。此外，卵黄囊肿瘤的特征是人类白细胞抗原I类的表达缺失。这些发现提示SerpinB9参与了睾丸生殖细胞肿瘤的免疫逃逸。因此，SerpinB9的靶向治疗可能有助于免疫检查点抑制剂抵抗睾丸生殖细胞肿瘤的免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.