Effects of nutritional indices and inflammatory parameters on patients received immunotherapy for non-small cell lung cancer

IF 2.5 4区医学 Q3 ONCOLOGY Current Problems in Cancer Pub Date : 2023-11-20 DOI:10.1016/j.currproblcancer.2023.101035

Hui-Ping Ding , Yi-Qun Ling , Wei Chen , Qin Ding , Liu-Qing Xu , Yan Wu , Qiong Wang , Tian-Hao Ni , Bing-Qin He

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Abstract

Objective

This research explored the relationship between a patient's nutritional state and inflammatory markers and the prognosis of their non-small cell lung cancer (NSCLC) treatment while receiving a combination of chemotherapy and immunotherapy.

Method

This retrospective and single-center analysis included NSCLC patients who received a combination of chemotherapy and immunotherapy at the Department of Oncology at Shanghai Lung Hospital. Patients were categorized based on malnutrition, sarcopenia, sarcopenic obesity, and advanced-lung-cancer-inflammation-index (ALI) scores after collecting nutritional and inflammatory indices. Kaplan-Meier and the Cox models were utilized to analyze survival.

Results

There was a significant correlation between malnutrition, sarcopenia, sarcopenic obesity, and low ALI scores with lower overall survival (OS) and progression-free survival (PFS) (p < 0.05). Low ALI score and malnutrition were independent factors influencing patient survival in terms of both OS and PFS (p < 0.01).

Conclusion

The nutritional and inflammatory indices of immunotherapy-treated NSCLC patients substantially affect their prognosis. Assessing these variables could aid in optimizing treatment strategies and improving patient outcomes. Additional research is required to comprehend the intricate relationship between nutrition, inflammation, and cancer progression and to develop individualized therapies.

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非小细胞肺癌患者接受免疫治疗后营养指标和炎症参数的影响。

目的:探讨非小细胞肺癌(NSCLC)患者接受化疗和免疫联合治疗时营养状况和炎症标志物与预后的关系。方法:本回顾性单中心分析纳入了在上海肺医院肿瘤科接受化疗和免疫治疗联合治疗的非小细胞肺癌患者。收集营养和炎症指数后，根据营养不良、肌肉减少症、肌肉减少性肥胖和晚期肺癌炎症指数(ALI)评分对患者进行分类。采用Kaplan-Meier模型和Cox模型分析生存率。结果:营养不良、肌少症、肌少性肥胖、ALI评分低与总生存期(OS)和无进展生存期(PFS)均有显著相关性(p < 0.05)。低ALI评分和营养不良是影响患者生存的独立因素(p < 0.01)。结论:免疫治疗的非小细胞肺癌患者的营养和炎症指标显著影响其预后。评估这些变量有助于优化治疗策略和改善患者预后。需要进一步的研究来理解营养、炎症和癌症进展之间的复杂关系，并开发个性化的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cancer 医学-肿瘤学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

15 days

期刊介绍： Current Problems in Cancer seeks to promote and disseminate innovative, transformative, and impactful data on patient-oriented cancer research and clinical care. Specifically, the journal''s scope is focused on reporting the results of well-designed cancer studies that influence/alter practice or identify new directions in clinical cancer research. These studies can include novel therapeutic approaches, new strategies for early diagnosis, cancer clinical trials, and supportive care, among others. Papers that focus solely on laboratory-based or basic science research are discouraged. The journal''s format also allows, on occasion, for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering articles that present dynamic material that influences the oncology field.