Mpox and HIV-Collision of Two Diseases.

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-23 DOI:10.1007/s11904-023-00682-w
Jason Zucker, Aniruddha Hazra, Boghuma K Titanji
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Abstract

Purpose of review: The global outbreak of mpox has brought renewed attention to a previously neglected disease which is particularly severe in people with underlying untreated HIV co-infection. For this population, the disease is progressive, severe, and often lethal. In this review, we examine the pathogenesis of mpox disease and its collision with co-existent HIV infection and discuss key considerations for management as well as emerging clinical dilemmas and areas for future research.

Recent findings: Co-existent untreated HIV infection characterized by severe immunocompromise potentiates the nefarious effects of monkeypox virus infection leading to severe manifestations of mpox. Treating mpox in the context of HIV requires mpox-directed therapies, supportive care, and HIV-specific treatment to restore immune function. Preventative measures for PWH are like those in healthy individuals, but the effectiveness and durability of protection conferred by existing vaccines in PWH remain to be fully characterized. Mpox is an important opportunistic infection in PWH. Clinicians should be aware of the unique features of the disease in this population and approaches to care and management of mpox in PWH.

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麻疹和hiv两种疾病的碰撞。
审查目的:mpox的全球暴发使人们重新关注以前被忽视的一种疾病,这种疾病在未经治疗的潜在艾滋病毒合并感染患者中尤为严重。对于这一人群,这种疾病是进行性的,严重的,而且往往是致命的。在这篇综述中,我们探讨了m痘病的发病机制及其与共存的HIV感染的冲突,并讨论了管理的关键注意事项以及新出现的临床困境和未来研究的领域。最近的发现:共存的未经治疗的HIV感染以严重的免疫功能低下为特征,增强了猴痘病毒感染的邪恶影响,导致严重的m痘表现。在艾滋病毒背景下治疗m痘需要针对m痘的治疗、支持性护理和艾滋病毒特异性治疗,以恢复免疫功能。PWH的预防措施与健康人的预防措施类似,但现有疫苗在PWH中所赋予的保护的有效性和持久性仍有待充分研究。Mpox是PWH中一种重要的机会性感染。临床医生应该意识到该疾病在这一人群中的独特特征以及在PWH中护理和管理m痘的方法。
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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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