Titanium particles in peri-implantitis: distribution, pathogenesis and prospects

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE International Journal of Oral Science Pub Date : 2023-11-23 DOI:10.1038/s41368-023-00256-x
Long Chen, Zian Tong, Hongke Luo, Yuan Qu, Xinhua Gu, Misi Si
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Abstract

Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease’s prevention and treatment. The underlying risk factors and detailed pathogenesis of peri-implantitis remain to be elucidated. Titanium-based implants as the most widely used implant inevitably release titanium particles into the surrounding tissue. Notably, the concentration of titanium particles increases significantly at peri-implantitis sites, suggesting titanium particles as a potential risk factor for the condition. Previous studies have indicated that titanium particles can induce peripheral osteolysis and foster the development of aseptic osteoarthritis in orthopedic joint replacement. However, it remains unconfirmed whether this phenomenon also triggers inflammation and bone resorption in peri-implant tissues. This review summarizes the distribution of titanium particles around the implant, the potential roles in peri-implantitis and the prevalent prevention strategies, which expects to provide new directions for the study of the pathogenesis and treatment of peri-implantitis.

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钛颗粒在种植体周围炎中的分布、发病机制及前景
种植体周围炎是口腔种植领域最重要的生物学并发症之一。确定种植体周围炎症和骨溶解的致病因素对疾病的预防和治疗至关重要。种植体周围炎的潜在危险因素和详细的发病机制仍有待阐明。钛基种植体是目前应用最广泛的种植体,不可避免地会向周围组织释放钛颗粒。值得注意的是,钛颗粒浓度在种植体周围明显增加,提示钛颗粒是该疾病的潜在危险因素。已有研究表明,在骨科关节置换术中,钛颗粒可诱导外周骨溶解,促进无菌性骨关节炎的发生。然而,这种现象是否也会引发种植体周围组织的炎症和骨吸收尚不确定。本文综述了钛颗粒在种植体周围的分布、在种植体周围炎中的潜在作用以及目前常见的预防策略,以期为种植体周围炎的发病机制和治疗研究提供新的方向。
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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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