Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement.

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-230118
Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud
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Abstract

Background: Zinc oxide eugenol (ZOE) cement is a popular dental material due mainly to its analgesic, antibacterial and anti-inflammatory effects. The formulation of ZOE cement from nano particle-sized zinc oxide (ZnO) has the potential to increase these properties as well as reduce its adverse effects to the surrounding tissues.

Objective: This study evaluated the subcutaneous tissue response towards nano ZOE cements (ZOE-A and ZOE-B) in comparison to conventional ZOE (ZOE-K).

Methods: Test materials were implanted into 15 New Zealand white rabbits. Tissue samples were obtained after 7, 14, and 30 days (n = 5 per period) for histopathological evaluation of inflammatory cell infiltrate, fibrous tissue condensation, and abscess formation.

Results: ZOE-A showed the lowest score for the variable macrophage and lymphocyte at day 7. Both ZOE-A and ZOE-B presented lower fibrous tissue condensation and abscess formation compared to conventional ZOE-K. By day 30, ZOE-A exhibited less lymphocytic and neutrophilic infiltrate compared to the other materials, while ZOE-B had the lowest score for macrophages. ZOE-K exerted higher inflammatory cell response at almost all of the experimental periods. All of the materials resulted in thin fiber condensation after 30 days.

Conclusions: Rabbit tissue implanted with ZOE-A and ZOE-B showed better response compared to ZOE-K.

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新型纳米氧化锌丁香酚牙水泥的皮下组织反应。
背景:氧化锌丁香酚(ZOE)水泥是一种流行的牙科材料,主要是因为它具有镇痛、抗菌和抗炎的作用。由纳米颗粒大小的氧化锌(ZnO)制成的ZOE水泥有可能增加这些性能,并减少其对周围组织的不利影响。目的:本研究评估纳米ZOE胶合剂(ZOE- a和ZOE- b)与常规ZOE胶合剂(ZOE- k)的皮下组织反应。方法:将实验材料植入15只新西兰大白兔体内。在第7、14和30天(每个周期n = 5)后获得组织样本,用于炎症细胞浸润、纤维组织凝结和脓肿形成的组织病理学评估。结果:ZOE-A在第7天表现为可变巨噬细胞和淋巴细胞评分最低。与传统的ZOE-K相比,ZOE-A和ZOE-B的纤维组织凝结和脓肿形成都较低。第30天,与其他材料相比,ZOE-A的淋巴细胞和中性粒细胞浸润较少,而ZOE-B的巨噬细胞评分最低。ZOE-K几乎在所有实验期间都表现出较高的炎症细胞反应。所有材料在30天后都出现了薄纤维凝结。结论:与ZOE-K相比,植入ZOE-A和ZOE-B的兔组织有更好的应答。
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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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