Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue.

IF 4.8 4区医学 Q2 IMMUNOLOGY International immunology Pub Date : 2024-01-29 DOI:10.1093/intimm/dxad045

Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa

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Abstract

We previously demonstrated that Alcaligenes-derived lipid A (ALA), which is produced from an intestinal lymphoid tissue-resident commensal bacterium, is an effective adjuvant for inducing antigen-specific immune responses. To understand the immunologic characteristics of ALA as a vaccine adjuvant, we here compared the adjuvant activity of ALA with that of a licensed adjuvant (monophosphoryl lipid A, MPLA) in mice. Although the adjuvant activity of ALA was only slightly greater than that of MPLA for subcutaneous immunization, ALA induced significantly greater IgA antibody production than did MPLA during nasal immunization. Regarding the underlying mechanism, ALA increased and activated CD11b+ CD103- CD11c+ dendritic cells in the nasal tissue by stimulating chemokine responses. These findings revealed the superiority of ALA as a mucosal adjuvant due to the unique immunologic functions of ALA in nasal tissue.

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碱性脂质A通过募集和激活鼻组织中CD11b+树突状细胞作为单磷酰脂质A的优越粘膜佐剂。

我们之前已经证明，Alcaligenes-derived脂质A (ALA)是一种有效的佐剂，可以诱导抗原特异性免疫反应，这种脂质A是由肠道淋巴组织中的共生细菌产生的。为了了解ALA作为疫苗佐剂的免疫学特性，我们在这里比较了ALA与一种许可佐剂(单磷酰脂质a, MPLA)在小鼠中的佐剂活性。虽然ALA在皮下免疫时的佐剂活性仅略高于MPLA，但在鼻腔免疫时，ALA诱导的IgA抗体产生明显高于MPLA。至于其潜在机制，ALA通过刺激趋化因子反应增加和激活鼻腔组织中的CD11b+ CD103- CD11c+树突状细胞。由于ALA在鼻组织中具有独特的免疫功能，这些发现揭示了ALA作为粘膜佐剂的优越性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunology 医学-免疫学

CiteScore

9.30

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.