Monoclonal antibody-navigated carbon-encapsulated iron nanoparticles used for MRI-based tracking integrin receptors in murine melanoma

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2023-11-24 DOI:10.1016/j.nano.2023.102721
Magdalena Bamburowicz-Klimkowska PhD , Michal Bystrzejewski PhD, DSc , Artur Kasprzak PhD, DSc , Andrzej Cieszanowski MD, PhD, Prof , Ireneusz P. Grudzinski PhD, DSc, Prof
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Abstract

Integrin beta-3 is a cell adhesion molecule that mediate cell-to-cell and cell-to-extracellular matrix communication. The major goal of this study was to explore melanoma cells (B16F10) based upon specific direct targeting of the β3 subunit (CD61) in the integrin αvβ3 receptor using carbon-encapsulated iron nanoparticles decorated with monoclonal antibodies (Fe@C-CONH-anti-CD61 and Fe@C-(CH2)2-CONH-anti-CD61). Both melanoma cells treated with nanoparticles as well as C57BL/6 mice bearing syngeneic B16-F10 tumors intravenously injected with nanoparticles were tested in preclinical MRI studies. The as-synthesized carbon-encapsulated iron nanoparticles functionalized with CD61 monoclonal antibodies have been successfully used as a novel targeted contrast agent for MRI-based tracking melanoma cells expressing the β3 subunit of the integrin αvβ3 receptor.

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单克隆抗体导航碳包裹铁纳米颗粒用于小鼠黑色素瘤中基于mri的整合素受体跟踪。
整合素-3是一种细胞粘附分子,介导细胞间和细胞外基质的通讯。本研究的主要目的是利用碳包覆铁纳米颗粒修饰单克隆抗体(Fe@C-CONH-anti-CD61和Fe@C-(CH2)2-CONH-anti-CD61),特异性直接靶向整合素αvβ3受体中β3亚基(CD61),探索黑色素瘤细胞(B16F10)。在临床前MRI研究中,用纳米颗粒处理的黑色素瘤细胞以及静脉注射纳米颗粒的携带同源B16-F10肿瘤的C57BL/6小鼠进行了测试。经CD61单克隆抗体修饰的碳包覆铁纳米颗粒已被成功用作一种新型靶向造影剂,用于基于mri追踪表达整合素αvβ3受体β3亚基的黑色素瘤细胞。
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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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