Hassan Valadbeigi, Saeed Khoshnood, Babak Negahdari, Abbas Maleki, Medya Mohammadinejat, Mohammad Hossein Haddadi
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引用次数: 0
Abstract
Background: Fusobacterium nucleatum (F. nucleatum) is an integral component of supra- and subgingival biofilms, especially more prevalent in subgingival areas during both periodontal health and disease.
Aims: In this review, we explore the physical, metabolic, and genetic interactions that influence the role of F. nucleatum in the formation of mixed oral biofilms. The role of F. nucleatum in antibiotic resistance in oral biofilms was discussed and some therapeutic strategies were proposed.
Methods: PubMed, Scopus, Google Scholar, and the Web of Science were extensively searched for English-language reports.
Results: F. nucleatum-derived proteins such as RadD, Fap2, FomA, and CmpA are involved in direct interactions contributing to biofilm formation, while autoinducer-2 and putrescine are involved in metabolic interactions. Both groups are essential for the formation and persistence of oral biofilms. This study highlights the clinical relevance of targeted interactions of F. nucleatum in supra- and subgingival oral biofilms.
Conclusions: By focusing on these interactions, researchers and clinicians can develop more effective strategies to prevent biofilm-related disease and reduce the spread of antibiotic resistance. Further research in this area is warranted to explore the potential therapeutic interventions that can be derived from understanding the interactions of F. nucleatum in oral biofilm dynamics.
背景:核梭杆菌(F. nucleatum)是牙龈上和牙龈下生物膜的一个组成部分,尤其在牙周健康和疾病期间在牙龈下区域更为普遍。目的:在这篇综述中,我们探讨了影响具核梭菌在混合口腔生物膜形成中的作用的物理、代谢和遗传相互作用。讨论了具核梭菌在口腔生物膜耐药中的作用,并提出了一些治疗策略。方法:广泛检索PubMed、Scopus、Google Scholar和Web of Science的英文报告。结果:F.核素衍生蛋白如RadD、Fap2、FomA和CmpA参与了促进生物膜形成的直接相互作用,而自诱导剂-2和腐胺参与了代谢相互作用。这两组对口腔生物膜的形成和持续都是必不可少的。这项研究强调了核仁梭菌在牙龈上和牙龈下口腔生物膜中的靶向相互作用的临床相关性。结论:通过关注这些相互作用,研究人员和临床医生可以制定更有效的策略来预防生物膜相关疾病并减少抗生素耐药性的传播。这一领域的进一步研究是有必要的,以探索潜在的治疗干预措施,可以从了解具核梭菌在口腔生物膜动力学中的相互作用中得到。
期刊介绍:
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.