Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumour: A Critical Review of the Rare and Distinctive Entity.

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI:10.1007/s12105-023-01602-5

Nan Xie, Zhipei Chen, Yi Liu, Jingbin Huo, Xiaohua Chen, Alfred King-Yin Lam

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Abstract

Background: The study aims to analyse the non-calcifying/Langerhans cell rich (NCLC) subtype of calcifying epithelial odontogenic tumour (CEOT). METHOD: The features of cases of the NCLC subtype of CEOT noted in the English literature by PubMed as well as 3 new cases were reviewed.

Results: Overall, twenty-one cases were noted. Many were women in the fourth to sixth decades (male-to-female ratio =1 to 2). Radiologically, the lesion is often unilocular with resorption of the affected teeth. Nineteen of the 21 cases occurred in the maxilla, especially the anterior portion. On pathological examination, epithelial cells are noted in non-calcifying amyloid-rich fibrous stroma. The main differential diagnosis is the amyloid subtype of central odontogenic fibroma. Immunohistochemical studies revealed the tumour epithelial cells were positive for cytokeratins and p63 and contained CD1a, S-100, and langerin-positive Langerhans cells. On a median follow-up of 2 years, one patient had a recurrence one year after curettage.

Conclusion: The NCLC subtype of CEOT is unique as it contains significant numbers of Langerhans cells and has clinicopathological features distinctive from classic CEOT.

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非钙化/朗格汉斯细胞丰富的钙化上皮牙源性肿瘤:罕见而独特的实体的重要回顾。

背景:本研究旨在分析钙化上皮性牙源性肿瘤(CEOT)的非钙化/富朗格汉斯细胞(NCLC)亚型。方法:回顾PubMed英文文献中报道的CEOT的NCLC亚型病例特点及3例新发病例。结果:共记录21例。许多是40至60岁的女性(男女比例= 1:2)。放射学上，病变通常是单眼的，受影响的牙齿有吸收。21例中有19例发生在上颌骨，尤其是前部。病理检查显示，在非钙化的富含淀粉样蛋白的纤维间质中可见上皮细胞。主要的鉴别诊断是淀粉样蛋白亚型的中央牙源性纤维瘤。免疫组化研究显示，肿瘤上皮细胞角蛋白和p63阳性，含有CD1a、S-100和朗格汉斯细胞阳性。中位随访2年，1例患者刮除后1年复发。结论:CEOT的NCLC亚型是独特的，它含有大量的朗格汉斯细胞，具有与典型CEOT不同的临床病理特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.