Solid-state inorganic and metallic adhesives for soft biological tissues

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2023-11-28 DOI:10.1016/j.jdsr.2023.11.003

Masahiro Okada, Takuya Matsumoto

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Abstract

Currently, the soft-tissue adhesives used in clinical practice are glue-type organic adhesives. However, there is a demand for new types of adhesives, because the current organic adhesives present challenges in terms of their biocompatibility and adhesion strength. This review summarizes the discovery and development of inorganic and metallic adhesives designed for soft biological tissues while focusing on immobilization of medical divices on soft tissues. These new types of adhesives are in a solid state and adhere directly and immediately to soft tissues. Therefore, they are called “solid-state adhesives” to distinguish them from the currently used glue-type adhesives. In previous studies on inorganic solid-state adhesives, oxides and calcium phosphates were used as raw materials in the form of nanoparticles, nanoparticle-coated films, or nanoparticle-assembled porous plates. In previous studies on metallic solid-state adhesives, only Ti and its alloys were used as raw materials. This review also discusses the future perspectives in this active research area.

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软生物组织用固体无机和金属胶粘剂

目前临床上使用的软组织粘接剂主要是胶型有机粘接剂。然而，由于目前的有机粘合剂在生物相容性和粘附强度方面存在挑战，因此对新型粘合剂的需求不断增加。本文综述了软性生物组织用无机和金属胶粘剂的发现和发展，重点介绍了医疗器械在软组织上的固定。这些新型的粘接剂是固态的，可以直接和立即粘附到软组织上。因此，它们被称为“固态粘合剂”，以区别于目前使用的胶水型粘合剂。在以往对无机固态粘合剂的研究中，氧化物和磷酸钙以纳米颗粒、纳米颗粒包覆薄膜或纳米颗粒组装多孔板的形式作为原料。在以往的金属固态胶粘剂研究中，只使用钛及其合金作为原料。本文还讨论了这一活跃研究领域的未来前景。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.