Japanese Dental Science Review最新文献

The role of large language models in dental diagnosis, decision-making, and communication: A systematic review 大型语言模型在牙科诊断、决策和沟通中的作用：系统回顾

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2026-01-27 DOI: 10.1016/j.jdsr.2026.01.002

Taibe TOKGÖZ KAPLAN , Gülbahar ERDİNÇ AKYOL

The integration of LLMs in the healthcare sector offers significant potential for improving medical practice and patient care. They assist in medical diagnosis by analyzing patient symptoms and other relevant data. This systematic review proposes to assess the existing literature on the use of LLMs. The comprehensive review was conducted in PubMed, Web of Science, Google Scholar and Scopus databases using keywords related to LLMs for articles published in English language at all times. Data was extracted to determine the applications, evaluation criteria and outcomes of LLMs in dentistry. Of 1142 records, 38 studies fulfilled the inclusion criteria. Among all studies, ChatGPT-3.5 was the most frequently used LLM. Most of the studies addressed patient questions during or after dental treatment. Most studies asked open-ended questions, and the Likert scale was the most used evaluation scale. This systematic review has shown that LLMs can increase efficiency, improve patient care and diagnostic support in dentistry. However, due to the risk of incorrect and incomplete information, LLMs should be used as clinical decision support tools. To increase their effectiveness and reliability, they should be trained on rigorously validated and continuously updated data sets.

llm在医疗保健领域的整合为改善医疗实践和患者护理提供了巨大的潜力。它们通过分析病人的症状和其他相关数据来协助医学诊断。本系统综述旨在评估llm使用的现有文献。综合评价在PubMed、Web of Science、b谷歌Scholar和Scopus数据库中进行，使用与法学硕士相关的关键词检索所有以英语发表的文章。提取数据以确定llm在牙科中的应用、评估标准和结果。在1142条记录中，38项研究符合纳入标准。在所有研究中，ChatGPT-3.5是使用频率最高的LLM。大多数研究都是针对患者在牙科治疗期间或之后的问题。大多数研究采用开放式问题，李克特量表是最常用的评估量表。本系统综述表明，llm可以提高效率，改善牙科患者护理和诊断支持。然而，由于信息不正确和不完整的风险，法学硕士应该被用作临床决策支持工具。为了提高它们的有效性和可靠性，它们应该接受严格验证和不断更新的数据集的训练。

{"title":"The role of large language models in dental diagnosis, decision-making, and communication: A systematic review","authors":"Taibe TOKGÖZ KAPLAN , Gülbahar ERDİNÇ AKYOL","doi":"10.1016/j.jdsr.2026.01.002","DOIUrl":"10.1016/j.jdsr.2026.01.002","url":null,"abstract":"<div><div>The integration of LLMs in the healthcare sector offers significant potential for improving medical practice and patient care. They assist in medical diagnosis by analyzing patient symptoms and other relevant data. This systematic review proposes to assess the existing literature on the use of LLMs<strong>.</strong> The comprehensive review was conducted in PubMed, Web of Science, Google Scholar and Scopus databases using keywords related to LLMs for articles published in English language at all times. Data was extracted to determine the applications, evaluation criteria and outcomes of LLMs in dentistry. Of 1142 records, 38 studies fulfilled the inclusion criteria. Among all studies, ChatGPT-3.5 was the most frequently used LLM. Most of the studies addressed patient questions during or after dental treatment. Most studies asked open-ended questions, and the Likert scale was the most used evaluation scale. This systematic review has shown that LLMs can increase efficiency, improve patient care and diagnostic support in dentistry. However, due to the risk of incorrect and incomplete information, LLMs should be used as clinical decision support tools. To increase their effectiveness and reliability, they should be trained on rigorously validated and continuously updated data sets.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"62 ","pages":"Pages 57-67"},"PeriodicalIF":6.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the diagnosis: Unraveling DSPP genotype-phenotype correlations in dentin dysplasia and dentinogenesis imperfecta 超越诊断：揭示牙本质发育不良和牙本质发育不全的DSPP基因型-表型相关性

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2026-01-15 DOI: 10.1016/j.jdsr.2026.01.001

Angkana Boonyakanog , Kanokrat Sriwangyang , Thamasorn Eamtanaporn , Annop Krasaesin , Kausar Sadia Fakhruddin , Soranun Chantarangsu , Sung-Dae Cho , Hamid A. Rokny , Thantrira Porntaveetus

The DSPP gene regulates dentin mineralisation, and its pathogenic variants cause a spectrum of defects ranging from dentin dysplasia (DD-II) to dentinogenesis imperfecta (DGI-II/III). Clinical variability often confounds diagnosis. This systematic review of 48 publications (70 variants, 99 records) delineates quantitative genotype–phenotype correlations. Results revealed distinct molecular clustering: Exon 5 harboured 61 % of variants, predominantly frameshifts disrupting the repetitive dentin phosphoprotein (DPP) domain. In contrast, upstream regions (exons 2–4) contained mixed variant types affecting the signal peptide and dentin sialoprotein (DSP). Statistical analysis established a definitive severity gradient. Exon 5 frameshifts were significantly associated with the milder DD-II, characterised by thistle-shaped pulps and clinically normal permanent dentition. Conversely, upstream signal peptide, splice site, and missense variants (exons 2–3) were linked to the severe DGI-III, manifesting as ‘shell teeth’, rapid attrition, and pulp exposure requiring complex prosthodontic intervention. DGI-II displayed no specific genomic clustering, representing an intermediate phenotype. These findings provide complementary insights to historical classifications, highlighting a continuous spectrum of DSPP disorders where upstream defects cause severe failure, while downstream defects result in attenuated localised anomalies. Consequently, integrating DSPP genotyping into diagnostic workflows is essential to predict disease progression, refine molecular taxonomy beyond the Shields system, and guide personalised rehabilitation.

DSPP基因调节牙本质矿化，其致病变异引起一系列缺陷，从牙本质发育不良（DD-II）到牙本质发育不全（DGI-II/III）。临床变化常使诊断混淆。本系统综述了48篇出版物（70个变异，99条记录），描述了基因型与表型的定量相关性。结果显示了明显的分子聚类：外显子5包含61% %的变异，主要是破坏重复牙本质磷酸化蛋白（DPP）结构域的帧移。相反，上游区域（外显子2-4）包含影响信号肽和牙本质唾液蛋白（DSP）的混合变异类型。统计分析建立了明确的严重性梯度。外显子5帧移与轻度DD-II显著相关，其特征是蓟状牙髓和临床正常的恒牙列。相反，上游信号肽、剪接位点和错义变异（外显子2-3）与严重的DGI-III有关，表现为“壳牙”、快速磨损和牙髓暴露，需要复杂的修复干预。DGI-II没有表现出特定的基因组聚类，代表一种中间表型。这些发现为历史分类提供了补充见解，强调了DSPP疾病的连续谱，其中上游缺陷导致严重失败，而下游缺陷导致轻度局部异常。因此，将DSPP基因分型整合到诊断工作流程中对于预测疾病进展、完善Shields系统之外的分子分类以及指导个性化康复至关重要。

{"title":"Beyond the diagnosis: Unraveling DSPP genotype-phenotype correlations in dentin dysplasia and dentinogenesis imperfecta","authors":"Angkana Boonyakanog , Kanokrat Sriwangyang , Thamasorn Eamtanaporn , Annop Krasaesin , Kausar Sadia Fakhruddin , Soranun Chantarangsu , Sung-Dae Cho , Hamid A. Rokny , Thantrira Porntaveetus","doi":"10.1016/j.jdsr.2026.01.001","DOIUrl":"10.1016/j.jdsr.2026.01.001","url":null,"abstract":"<div><div>The <em>DSPP</em> gene regulates dentin mineralisation, and its pathogenic variants cause a spectrum of defects ranging from dentin dysplasia (DD-II) to dentinogenesis imperfecta (DGI-II/III). Clinical variability often confounds diagnosis. This systematic review of 48 publications (70 variants, 99 records) delineates quantitative genotype–phenotype correlations. Results revealed distinct molecular clustering: Exon 5 harboured 61 % of variants, predominantly frameshifts disrupting the repetitive dentin phosphoprotein (DPP) domain. In contrast, upstream regions (exons 2–4) contained mixed variant types affecting the signal peptide and dentin sialoprotein (DSP). Statistical analysis established a definitive severity gradient. Exon 5 frameshifts were significantly associated with the milder DD-II, characterised by thistle-shaped pulps and clinically normal permanent dentition. Conversely, upstream signal peptide, splice site, and missense variants (exons 2–3) were linked to the severe DGI-III, manifesting as ‘shell teeth’, rapid attrition, and pulp exposure requiring complex prosthodontic intervention. DGI-II displayed no specific genomic clustering, representing an intermediate phenotype. These findings provide complementary insights to historical classifications, highlighting a continuous spectrum of <em>DSPP</em> disorders where upstream defects cause severe failure, while downstream defects result in attenuated localised anomalies. Consequently, integrating <em>DSPP</em> genotyping into diagnostic workflows is essential to predict disease progression, refine molecular taxonomy beyond the Shields system, and guide personalised rehabilitation.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"62 ","pages":"Pages 46-56"},"PeriodicalIF":6.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the optimal irrigation activation or agitation techniques for postoperative pain control: A network meta-regression of clinical trials 确定术后疼痛控制的最佳冲洗激活或搅拌技术：临床试验的网络meta回归

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-12-18 DOI: 10.1016/j.jdsr.2025.12.001

Fatma Pertek Hatipoğlu , Merve Çoban Öksüzer , Mohmed Isaqali Karobari , Ömer Hatipoğlu

Postoperative pain after root canal treatment remains a frequent clinical problem despite advances in instruments and irrigants. This Bayesian systematic review and network meta-regression compared seven irrigation activation/agitation techniques—positive pressure, manual dynamic, sonic, ultrasonic, multisonic, negative-pressure and laser-activated irrigation—with respect to Day-1 postoperative pain. Electronic searches of PubMed, Cochrane Library, Scopus and Web of Science were conducted up to 10 December 2024; 57 trials (2595 patients) were included qualitatively and 31 contributed to the quantitative network. Pain scores were rescaled to a 0–10 scale and analysed as mean differences, with symptomatic status modelled as an ordinal covariate and treatment rankings summarised using SUCRA values. Laser-activated irrigation (LAI) produced the lowest Day-1 pain and showed a clinically important advantage over manual dynamic irrigation (MDI) exceeding the 1.0-point minimal clinically important difference, while also outperforming positive pressure and ultrasonic irrigation with smaller, statistically but not clinically important effects. Multisonic and negative-pressure irrigation also ranked favourably, whereas MDI consistently showed the highest pain scores and the lowest SUCRA values. Baseline symptomatic status was a strong effect modifier, with symptomatic teeth experiencing substantially higher pain irrespective of technique. Overall CINeMA confidence was low to very low for most contrasts, indicating that these findings should be interpreted cautiously and highlighting the need for larger, better-designed trials with standardised pain-assessment protocols.

尽管器械和冲洗剂的进步，根管治疗后的术后疼痛仍然是常见的临床问题。本贝叶斯系统综述和网络元回归比较了7种冲洗激活/搅拌技术——正压、手动动态、超声、超声、多超声、负压和激光激活冲洗——对术后第1天疼痛的影响。PubMed、Cochrane Library、Scopus和Web of Science的电子检索截止到2024年12月10日；57项试验（2595例患者）被定性纳入，31项纳入定量网络。疼痛评分被重新调整为0-10分，并作为平均差异进行分析，症状状态建模为有序协变量，并使用SUCRA值总结治疗排名。激光激活灌洗（LAI）产生的第1天疼痛最低，与人工动态灌洗（MDI）相比具有临床重要优势，超过了1.0分的最小临床重要差异，同时也优于正压灌洗和超声灌洗，但效果较小，具有统计学意义，但不具有临床重要意义。多声压灌洗和负压灌洗的评分也较好，而MDI的疼痛评分最高，SUCRA值最低。基线症状状态是一个强大的效果调节因素，有症状的牙齿经历明显更高的疼痛，与技术无关。总的来说，对于大多数对比，CINeMA的可信度很低，表明这些发现应该谨慎解释，并强调需要更大规模、设计更好的试验，并采用标准化的疼痛评估方案。

{"title":"Determining the optimal irrigation activation or agitation techniques for postoperative pain control: A network meta-regression of clinical trials","authors":"Fatma Pertek Hatipoğlu , Merve Çoban Öksüzer , Mohmed Isaqali Karobari , Ömer Hatipoğlu","doi":"10.1016/j.jdsr.2025.12.001","DOIUrl":"10.1016/j.jdsr.2025.12.001","url":null,"abstract":"<div><div>Postoperative pain after root canal treatment remains a frequent clinical problem despite advances in instruments and irrigants. This Bayesian systematic review and network meta-regression compared seven irrigation activation/agitation techniques—positive pressure, manual dynamic, sonic, ultrasonic, multisonic, negative-pressure and laser-activated irrigation—with respect to Day-1 postoperative pain. Electronic searches of PubMed, Cochrane Library, Scopus and Web of Science were conducted up to 10 December 2024; 57 trials (2595 patients) were included qualitatively and 31 contributed to the quantitative network. Pain scores were rescaled to a 0–10 scale and analysed as mean differences, with symptomatic status modelled as an ordinal covariate and treatment rankings summarised using SUCRA values. Laser-activated irrigation (LAI) produced the lowest Day-1 pain and showed a clinically important advantage over manual dynamic irrigation (MDI) exceeding the 1.0-point minimal clinically important difference, while also outperforming positive pressure and ultrasonic irrigation with smaller, statistically but not clinically important effects. Multisonic and negative-pressure irrigation also ranked favourably, whereas MDI consistently showed the highest pain scores and the lowest SUCRA values. Baseline symptomatic status was a strong effect modifier, with symptomatic teeth experiencing substantially higher pain irrespective of technique. Overall CINeMA confidence was low to very low for most contrasts, indicating that these findings should be interpreted cautiously and highlighting the need for larger, better-designed trials with standardised pain-assessment protocols.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"62 ","pages":"Pages 26-45"},"PeriodicalIF":6.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy and feasibility of artificial intelligence-driven smartphone imaging for dental caries detection: A systematic review 人工智能驱动的智能手机成像诊断龋齿的准确性和可行性：系统综述

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-12-10 DOI: 10.1016/j.jdsr.2025.11.001

Joseph Macadaeg Acosta , Alexander Patera Nugraha , Kunhua Yang , Juan Ramón Vanegas Sáenz , Aobo Ma , Pagaporn Pantuwadee Pisarnturakit , Guang Hong

Objectives

This systematic review assesses the diagnostic accuracy, feasibility, and clinical performance of artificial intelligence (AI)-based smartphone imaging tools for detecting dental caries.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Diagnostic Test Accuracy (PRISMA-DTA) guidelines, five databases: PubMed, Scopus, Web of Science, Embase, and Cochrane Library, were searched up to March 26, 2025. This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD420251047689). Diagnostic accuracy and feasibility of AI-driven analysis of smartphone-based dental images for the detection of dental caries were assessed. Risk of bias and applicability were evaluated using QUADAS-2.

Results

Fourteen studies met the inclusion criteria. AI models, particularly YOLO variants, DenseNet201, and MobileNetV3, demonstrated high diagnostic accuracy, especially for cavitated lesions, with some outperforming junior dentists. Enhanced YOLO models achieved up to 85.5 % mean average precision. Tools were generally user-friendly and suitable for community or at-home screening. However, sensitivity for early or non-cavitated lesions varied.

Conclusion

AI-driven smartphone imaging shows promise as an accessible and reliable tool for caries detection, particularly in low-resource or remote settings. Further research is needed to improve early lesion detection, ensure clinical validation, and support equitable implementation.

目的系统评价基于人工智能（AI）的智能手机成像工具诊断龋病的准确性、可行性和临床表现。方法根据诊断测试准确性系统评价和荟萃分析的首选报告项目（PRISMA-DTA）指南，检索截至2025年3月26日的5个数据库：PubMed、Scopus、Web of Science、Embase和Cochrane Library。本研究已在国际前瞻性系统评价登记册（PROSPERO）注册（CRD420251047689）。评估了基于智能手机的牙齿图像的ai驱动分析用于检测龋齿的诊断准确性和可行性。使用QUADAS-2评估偏倚风险和适用性。结果14项研究符合纳入标准。人工智能模型，特别是YOLO变体、DenseNet201和MobileNetV3，表现出很高的诊断准确性，特别是对空化病变，其中一些表现优于初级牙医。增强的YOLO模型达到了85.5 %的平均精度。工具通常是用户友好的，适合社区或家庭筛查。然而，对早期或非空化病变的敏感性各不相同。结论人工智能驱动的智能手机成像有望成为一种可获得且可靠的龋齿检测工具，特别是在资源匮乏或偏远地区。需要进一步的研究来改善早期病变发现，确保临床验证，并支持公平实施。

{"title":"Diagnostic accuracy and feasibility of artificial intelligence-driven smartphone imaging for dental caries detection: A systematic review","authors":"Joseph Macadaeg Acosta , Alexander Patera Nugraha , Kunhua Yang , Juan Ramón Vanegas Sáenz , Aobo Ma , Pagaporn Pantuwadee Pisarnturakit , Guang Hong","doi":"10.1016/j.jdsr.2025.11.001","DOIUrl":"10.1016/j.jdsr.2025.11.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review assesses the diagnostic accuracy, feasibility, and clinical performance of artificial intelligence (AI)-based smartphone imaging tools for detecting dental caries.</div></div><div><h3>Methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Diagnostic Test Accuracy (PRISMA-DTA) guidelines, five databases: PubMed, Scopus, Web of Science, Embase, and Cochrane Library, were searched up to March 26, 2025. This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD420251047689). Diagnostic accuracy and feasibility of AI-driven analysis of smartphone-based dental images for the detection of dental caries were assessed. Risk of bias and applicability were evaluated using QUADAS-2.</div></div><div><h3>Results</h3><div>Fourteen studies met the inclusion criteria. AI models, particularly YOLO variants, DenseNet201, and MobileNetV3, demonstrated high diagnostic accuracy, especially for cavitated lesions, with some outperforming junior dentists. Enhanced YOLO models achieved up to 85.5 % mean average precision. Tools were generally user-friendly and suitable for community or at-home screening. However, sensitivity for early or non-cavitated lesions varied.</div></div><div><h3>Conclusion</h3><div>AI-driven smartphone imaging shows promise as an accessible and reliable tool for caries detection, particularly in low-resource or remote settings. Further research is needed to improve early lesion detection, ensure clinical validation, and support equitable implementation.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"62 ","pages":"Pages 14-25"},"PeriodicalIF":6.6,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which is the best adhesive system for primary tooth enamel? A systematic review and network meta-analysis of bond strength data 对于初级牙釉质，哪一种是最好的粘接系统？结合强度数据的系统回顾和网络元分析

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-12-06 DOI: 10.1016/j.jdsr.2025.11.005

Francisca Jennifer Duarte de Oliveira , Maria Larissa da Silva Flor , Mariana Silva de Bessa , Bárbara Faria de Sá Barbosa , Patrick Wesley Marques de Boa , Rodolfo Xavier de Sousa-Lima , Boniek Castillo Dutra Borges

Purpose

Evaluate the bond strength performance of the different types of adhesive systems to the primary tooth enamel.

Methods

This study was registered in the Open Science Framework (https://doi.org/10.17605/OSF.IO/YURB4). A two-stage literature search was conducted by two independent reviewers on PubMed, Embase, Web of Science, Scopus, and gray literature to identify in vitro studies evaluating the bond strength of different adhesive systems to primary tooth enamel. The risk of bias was evaluated with the QUIN tool. A Bayesian network meta-analysis was conducted to evaluate the bond strength at 24 h.

Results

The final sample was composed of 14 articles. The 2-bottle universal adhesive system with phosphoric acid etching (PAE) was statistically similar to the 3-step etch-and-rinse (E&R). In addition, self-etch and etch-and-rinse adhesives with the same number of steps had similar performances. In the ranking, 3-step E&R had the highest probability of being ranked the best adhesive, while 1-step self-etch without PAE had the lowest. All studies had a low risk of bias.

Conclusion

2-bottle universal adhesive systems with PAE can probably provide similar bond strength to primary tooth enamel compared to 3-Step E&R. In addition, the similar performance of some of the tested adhesive systems indicates the possibility to reduce clinical steps.

目的评价不同类型的粘接系统对原牙釉质的粘接强度。方法本研究已在开放科学框架（https://doi.org/10.17605/OSF.IO/YURB4）注册。两位独立审稿人在PubMed、Embase、Web of Science、Scopus和灰色文献上进行了两阶段的文献检索，以确定评估不同粘接剂系统与初级牙釉质粘合强度的体外研究。使用QUIN工具评估偏倚风险。采用贝叶斯网络元分析评估24 h时的粘结强度。结果最终样本共14篇。2瓶通用胶粘剂系统与磷酸蚀刻（PAE）在统计学上与3步蚀刻和冲洗（E&；R）相似。此外，相同步数的自蚀刻和蚀刻-漂洗胶粘剂具有相似的性能。在排名中，3步E&；R被评为最佳粘合剂的概率最高，而无PAE的1步自蚀刻的概率最低。所有研究的偏倚风险都很低。结论2瓶PAE万能粘接剂系统与3-Step E&；R粘接剂系统对原牙釉质的粘接强度相近。此外，一些测试粘合剂系统的类似性能表明可能减少临床步骤。

{"title":"Which is the best adhesive system for primary tooth enamel? A systematic review and network meta-analysis of bond strength data","authors":"Francisca Jennifer Duarte de Oliveira , Maria Larissa da Silva Flor , Mariana Silva de Bessa , Bárbara Faria de Sá Barbosa , Patrick Wesley Marques de Boa , Rodolfo Xavier de Sousa-Lima , Boniek Castillo Dutra Borges","doi":"10.1016/j.jdsr.2025.11.005","DOIUrl":"10.1016/j.jdsr.2025.11.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Evaluate the bond strength performance of the different types of adhesive systems to the primary tooth enamel.</div></div><div><h3>Methods</h3><div>This study was registered in the Open Science Framework (<span><span>https://doi.org/10.17605/OSF.IO/YURB4</span><svg><path></path></svg></span>). A two-stage literature search was conducted by two independent reviewers on PubMed, Embase, Web of Science, Scopus, and gray literature to identify <em>in vitro</em> studies evaluating the bond strength of different adhesive systems to primary tooth enamel. The risk of bias was evaluated with the QUIN tool. A Bayesian network meta-analysis was conducted to evaluate the bond strength at 24 h.</div></div><div><h3>Results</h3><div>The final sample was composed of 14 articles. The 2-bottle universal adhesive system with phosphoric acid etching (PAE) was statistically similar to the 3-step etch-and-rinse (E&R). In addition, self-etch and etch-and-rinse adhesives with the same number of steps had similar performances. In the ranking, 3-step E&R had the highest probability of being ranked the best adhesive, while 1-step self-etch without PAE had the lowest. All studies had a low risk of bias.</div></div><div><h3>Conclusion</h3><div>2-bottle universal adhesive systems with PAE can probably provide similar bond strength to primary tooth enamel compared to 3-Step E&R. In addition, the similar performance of some of the tested adhesive systems indicates the possibility to reduce clinical steps.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"62 ","pages":"Pages 1-13"},"PeriodicalIF":6.6,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145685839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues 揭示牙齿细胞景观：人类牙齿组织单细胞RNA测序的全面回顾

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-12-01 DOI: 10.1016/j.jdsr.2025.11.004

Maanas S. Shah , Takeru Kondo , Mano Sundarabupathi , Lakshman P. Samaranayake , Mohamed Jamal , Hiroshi Egusa

Single-cell RNA sequencing (scRNA-seq) has advanced the understanding of cellular heterogeneity and molecular dynamics in human dental tissues. This systematic review critically evaluated scRNA-seq studies exploring the cellular composition of human dental tissues, comparing in situ and cultured environments under both healthy and diseased conditions. Original research articles meeting the inclusion criteria were assessed for cell type identification, transcriptional profiles, analytical platforms, and other key biological insights by two independent authors. A total of fifteen studies that met the inclusion criteria revealed diverse cell populations, including mesenchymal stem cells (MSCs), immune cells, endothelial cells, and odontoblast-like cells, each exhibiting distinct transcriptional signatures in homeostasis, regeneration, and disease. Key findings included distinct MSC subpopulations, including THY1⁺, CD24⁺, FRZB⁺, and NOTCH3⁺/PDGFRB⁺, exhibiting unique differentiation potential, along with significant heterogeneity in odontoblast lineage. Moreover, carious dental pulp undergoes a fibrotic transcriptional shift (e.g., COL1A1, FN1, and TNC), whereas periodontitis exhibits increased expression of pro-inflammatory cytokines (IL-1β and TNFα) and diminished periodontal MSC regenerative capacity. This review underscores the contributions of scRNA-seq in providing unprecedented insights into the complexity and functional heterogeneity of dental tissues, offering a foundation for advancing targeted regenerative therapies and guiding future translational research in dental medicine.

单细胞RNA测序（scRNA-seq）促进了对人类牙齿组织细胞异质性和分子动力学的理解。这篇系统综述批判性地评估了scRNA-seq研究，探讨了人类牙齿组织的细胞组成，比较了健康和患病条件下的原位和培养环境。符合纳入标准的原创研究文章由两位独立作者评估细胞类型鉴定、转录谱、分析平台和其他关键生物学见解。总共有15项符合纳入标准的研究揭示了不同的细胞群，包括间充质干细胞（MSCs）、免疫细胞、内皮细胞和成牙细胞样细胞，每种细胞在体内平衡、再生和疾病中都表现出不同的转录特征。主要发现包括不同的MSC亚群，包括THY1+、CD24+、FRZB+和NOTCH3+/PDGFRB+，表现出独特的分化潜力，以及成牙细胞谱系的显著异质性。此外，龋齿牙髓经历纤维化转录转移（例如COL1A1， FN1和TNC），而牙周炎表现出促炎细胞因子（IL-1β和TNFα）的表达增加和牙周间充质干细胞再生能力下降。这篇综述强调了scRNA-seq的贡献，它为深入了解牙齿组织的复杂性和功能异质性提供了前所未有的见解，为推进靶向再生治疗和指导未来牙科医学的转化研究提供了基础。

{"title":"Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues","authors":"Maanas S. Shah , Takeru Kondo , Mano Sundarabupathi , Lakshman P. Samaranayake , Mohamed Jamal , Hiroshi Egusa","doi":"10.1016/j.jdsr.2025.11.004","DOIUrl":"10.1016/j.jdsr.2025.11.004","url":null,"abstract":"<div><div>Single-cell RNA sequencing (scRNA-seq) has advanced the understanding of cellular heterogeneity and molecular dynamics in human dental tissues. This systematic review critically evaluated scRNA-seq studies exploring the cellular composition of human dental tissues, comparing <em>in situ</em> and cultured environments under both healthy and diseased conditions. Original research articles meeting the inclusion criteria were assessed for cell type identification, transcriptional profiles, analytical platforms, and other key biological insights by two independent authors. A total of fifteen studies that met the inclusion criteria revealed diverse cell populations, including mesenchymal stem cells (MSCs), immune cells, endothelial cells, and odontoblast-like cells, each exhibiting distinct transcriptional signatures in homeostasis, regeneration, and disease. Key findings included distinct MSC subpopulations, including <em>THY1</em><sup>+</sup>, <em>CD24</em><sup>+</sup>, <em>FRZB</em><sup>+</sup>, and <em>NOTCH3</em><sup>+</sup>/<em>PDGFRB</em><sup>+</sup>, exhibiting unique differentiation potential, along with significant heterogeneity in odontoblast lineage. Moreover, carious dental pulp undergoes a fibrotic transcriptional shift (e.g., <em>COL1A1</em>, <em>FN1</em>, and <em>TNC</em>), whereas periodontitis exhibits increased expression of pro-inflammatory cytokines (<em>IL-1β</em> and <em>TNFα)</em> and diminished periodontal MSC regenerative capacity. This review underscores the contributions of scRNA-seq in providing unprecedented insights into the complexity and functional heterogeneity of dental tissues, offering a foundation for advancing targeted regenerative therapies and guiding future translational research in dental medicine.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 301-316"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral diseases as emerging risk factors for Alzheimer’s disease: A scoping review 口腔疾病是阿尔茨海默病的新危险因素：范围综述

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-11-17 DOI: 10.1016/j.jdsr.2025.11.003

Yuseung Yi , Chang-Ha Lee , Hyun-Seung Shin , Seungil Shin

This scoping review examined current evidence on the relationship between oral diseases and Alzheimer’s disease (AD). Systematic searches were conducted in PubMed, Scopus, Web of Science, Google Scholar, and KMbase for studies published from 1990 to December 2024, using terms of Alzheimer’s disease, dementia, oral health, periodontal disease, dental caries, and tooth loss. Human and validated animal studies investigating microbiological, immunological, inflammatory, genetic, or functional links between oral health and AD were included. Of 1328 records, 841 remained after duplicates were removed, and 98 were reviewed in full; 45 met inclusion criteria. Findings were organized into four themes: general associations; periodontal disease and AD, including inflammation, amyloid-β pathways, and APOE4-related susceptibility; dental caries; and tooth loss with prosthetic rehabilitation. Evidence indicates that chronic oral diseases, especially periodontitis and tooth loss, are associated with increased risk of AD and its progression through mechanisms involving systemic inflammation, microbial translocation, amyloidogenic processes, genetic predisposition, and impaired masticatory function. Appropriate prosthetic rehabilitation may help reduce dementia risk by restoring chewing function and supporting nutrition. While causality has yet to be established, maintaining oral health throughout life may be a practical, cost-effective component of strategies to promote cognitive health in older adults.

本综述审查了口腔疾病与阿尔茨海默病（AD）之间关系的现有证据。系统检索PubMed、Scopus、Web of Science、b谷歌Scholar和KMbase中1990年至2024年12月发表的研究，使用阿尔茨海默病、痴呆、口腔健康、牙周病、龋齿和牙齿脱落等术语。研究人员对口腔健康与阿尔茨海默病之间的微生物、免疫学、炎症、遗传或功能联系进行了人类和经过验证的动物研究。在1328项记录中，841项在删除重复后保留下来，98项被完全审查；45例符合纳入标准。调查结果分为四个主题：一般关联；牙周病和AD，包括炎症、淀粉样蛋白-β通路和apoe4相关易感性；龋齿;用假肢修复牙齿脱落。有证据表明，慢性口腔疾病，特别是牙周炎和牙齿脱落，与AD的风险增加及其进展相关，其机制包括全身性炎症、微生物易位、淀粉样变性过程、遗传易感性和咀嚼功能受损。适当的假肢康复可以通过恢复咀嚼功能和支持营养来帮助降低痴呆风险。虽然因果关系尚未确定，但在一生中保持口腔健康可能是促进老年人认知健康战略的一个实际的、具有成本效益的组成部分。

{"title":"Oral diseases as emerging risk factors for Alzheimer’s disease: A scoping review","authors":"Yuseung Yi , Chang-Ha Lee , Hyun-Seung Shin , Seungil Shin","doi":"10.1016/j.jdsr.2025.11.003","DOIUrl":"10.1016/j.jdsr.2025.11.003","url":null,"abstract":"<div><div>This scoping review examined current evidence on the relationship between oral diseases and Alzheimer’s disease (AD). Systematic searches were conducted in PubMed, Scopus, Web of Science, Google Scholar, and KMbase for studies published from 1990 to December 2024, using terms of Alzheimer’s disease, dementia, oral health, periodontal disease, dental caries, and tooth loss. Human and validated animal studies investigating microbiological, immunological, inflammatory, genetic, or functional links between oral health and AD were included. Of 1328 records, 841 remained after duplicates were removed, and 98 were reviewed in full; 45 met inclusion criteria. Findings were organized into four themes: general associations; periodontal disease and AD, including inflammation, amyloid-β pathways, and APOE4-related susceptibility; dental caries; and tooth loss with prosthetic rehabilitation. Evidence indicates that chronic oral diseases, especially periodontitis and tooth loss, are associated with increased risk of AD and its progression through mechanisms involving systemic inflammation, microbial translocation, amyloidogenic processes, genetic predisposition, and impaired masticatory function. Appropriate prosthetic rehabilitation may help reduce dementia risk by restoring chewing function and supporting nutrition. While causality has yet to be established, maintaining oral health throughout life may be a practical, cost-effective component of strategies to promote cognitive health in older adults.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 292-300"},"PeriodicalIF":6.6,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactivity and potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials for geriatric oral health: A scoping review 含表面预反应玻璃离聚体（S-PRG）填充材料在老年口腔健康中的生物活性和潜在应用综述

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-11-08 DOI: 10.1016/j.jdsr.2025.11.002

Thein Soe , Akiho Sunami , Okkar Kyaw , Keita Hatano , Manabu Kanazawa , Masanao Inokoshi

This scoping review explores the potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials in geriatric dentistry. A literature search across four databases (CINAHL, MEDLINE, PubMed, and Web of Science) identified 324 articles, of which 51, including 39 in vitro, 1 in situ, 1 preclinical, and 10 clinical studies, met the inclusion criteria. These reports demonstrate that, across the domains of preventive, restorative, endodontic, and prosthodontic dentistry, S-PRG filler-containing materials consistently exhibit bioactive properties, such as fluoride-release and recharge, multi-ion release, acid-buffering, anti-demineralization, remineralization, and antimicrobial activity. In preventive dentistry, S-PRG filler-based dentin coating agents, varnishes, and toothpastes show promising effects for caries prevention and periodontal pathogen control. In restorative dentistry, S-PRG filler-based composites and adhesives demonstrate bioactivity and favorable long-term clinical results. In prosthodontics, S-PRG filler-based denture base resins, tissue conditioners, and denture adhesives offer protective and antimicrobial effects. These multifunctional properties support the roles of S-PRG filler-containing dental materials as both preventive and therapeutic agents for managing common oral health issues in older adults, including root caries, periodontal disease, and denture stomatitis. Further clinical and longitudinal studies are needed to confirm their effectiveness and guide their use in geriatric care.

本文综述了含表面预反应玻璃离子聚合物（S-PRG）填充材料在老年牙科中的潜在应用。在四个数据库（CINAHL、MEDLINE、PubMed和Web of Science）中检索了324篇文献，其中51篇符合纳入标准，包括39项体外研究、1项原位研究、1项临床前研究和10项临床研究。这些报告表明，在预防、修复、牙髓和修复等牙科领域，含S-PRG填料的材料始终表现出生物活性，如氟化物释放和充电、多离子释放、酸缓冲、抗脱矿、再矿化和抗菌活性。在预防性牙科中，S-PRG填料基牙本质涂层剂、清漆和牙膏在预防龋齿和控制牙周病原体方面显示出良好的效果。在牙科修复中，S-PRG填料基复合材料和粘接剂显示出生物活性和良好的长期临床效果。在口腔修复学中，S-PRG填料基义齿基托树脂、组织调节剂和义齿粘接剂具有保护和抗菌作用。这些多功能特性支持含S-PRG填料的牙科材料作为预防和治疗老年人常见口腔健康问题的药物，包括牙根龋齿、牙周病和假牙口炎。需要进一步的临床和纵向研究来证实其有效性并指导其在老年护理中的应用。

{"title":"Bioactivity and potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials for geriatric oral health: A scoping review","authors":"Thein Soe , Akiho Sunami , Okkar Kyaw , Keita Hatano , Manabu Kanazawa , Masanao Inokoshi","doi":"10.1016/j.jdsr.2025.11.002","DOIUrl":"10.1016/j.jdsr.2025.11.002","url":null,"abstract":"<div><div>This scoping review explores the potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials in geriatric dentistry. A literature search across four databases (CINAHL, MEDLINE, PubMed, and Web of Science) identified 324 articles, of which 51, including 39 <em>in vitro</em>, 1 <em>in situ</em>, 1 preclinical, and 10 clinical studies, met the inclusion criteria. These reports demonstrate that, across the domains of preventive, restorative, endodontic, and prosthodontic dentistry, S-PRG filler-containing materials consistently exhibit bioactive properties, such as fluoride-release and recharge, multi-ion release, acid-buffering, anti-demineralization, remineralization, and antimicrobial activity. In preventive dentistry, S-PRG filler-based dentin coating agents, varnishes, and toothpastes show promising effects for caries prevention and periodontal pathogen control. In restorative dentistry, S-PRG filler-based composites and adhesives demonstrate bioactivity and favorable long-term clinical results. In prosthodontics, S-PRG filler-based denture base resins, tissue conditioners, and denture adhesives offer protective and antimicrobial effects. These multifunctional properties support the roles of S-PRG filler-containing dental materials as both preventive and therapeutic agents for managing common oral health issues in older adults, including root caries, periodontal disease, and denture stomatitis. Further clinical and longitudinal studies are needed to confirm their effectiveness and guide their use in geriatric care.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 280-291"},"PeriodicalIF":6.6,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between oral health parameters and nutritional status in geriatric populations: An umbrella review with meta-analysis 老年人群口腔健康参数与营养状况之间的关系：一项综合综述和荟萃分析

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-11-01 DOI: 10.1016/j.jdsr.2025.10.002

Wafa Ali Asaad , Salah Ameen Abdu , Wenjie Li , Yunqi Li , Yunhong Lin , Chun Yang , Xingxing Li

Background

Oral health impairments may compromise dietary intake and increase malnutrition risk in older adults. This review quantified associations between oral health indicators and malnutrition risk while synthesizing qualitative evidence.

Methods

Following PRISMA 2020 guidelines, we searched five databases for systematic reviews examining oral health indicators and nutritional outcomes in older adults. Quality was assessed using the JBI Critical Appraisal Checklist. RevMan 5.4 was used for meta-analyses, with sensitivity analyses using Comprehensive Meta-Analysis v3.7.

Results

Sixteen systematic reviews (518,647 participants) were included. Functional problems (chewing difficulty, xerostomia) were more associated with malnutrition than structural indicators, and while edentulism was frequently related to increased risk, dentures showed mixed correlations. Meta-analysis showed malnutrition risk was associated with masticatory dysfunction (RR) (1.75; p = 0.0001) and edentulism without dentures (RR) (1.71; p < 0.0005), but not with dental prostheses (RR) (1.01; p = 0.96); tooth count showed no significant association (MD) (-0.16; p = 0.19).

Conclusions

Functional oral impairment, particularly masticatory dysfunction and edentulism without dentures is more likely associated with malnutrition. Routine integration of oral and nutritional screening in geriatric care is warranted, with standardized measures needed to clarify the impact of salivary function and prosthetic rehabilitation on nutritional outcomes.

背景：口腔健康损害可能影响老年人的饮食摄入，增加营养不良的风险。本综述在综合定性证据的同时量化了口腔健康指标与营养不良风险之间的关联。方法根据PRISMA 2020指南，我们检索了五个数据库，对老年人的口腔健康指标和营养结果进行了系统评价。使用JBI关键评估清单对质量进行评估。meta分析采用RevMan 5.4，敏感性分析采用Comprehensive Meta-Analysis v3.7。结果共纳入16项系统评价（518,647名受试者）。与结构指标相比，功能问题（咀嚼困难、口干）与营养不良的关系更大，而假牙通常与风险增加有关，假牙则表现出混合的相关性。meta分析显示，营养不良风险与咀嚼功能障碍（RR）（1.75; p = 0.0001）和无义齿（RR）（1.71; p <； 0.0005）相关，与义齿（RR）（1.01; p = 0.96）无关；牙数无显著相关性（MD）（-0.16; p = 0.19）。结论口腔功能障碍，尤其是咀嚼功能障碍和无义齿缺牙更可能与营养不良有关。口腔和营养筛查在老年护理中的常规整合是必要的，需要标准化的措施来阐明唾液功能和假肢康复对营养结果的影响。

{"title":"Associations between oral health parameters and nutritional status in geriatric populations: An umbrella review with meta-analysis","authors":"Wafa Ali Asaad , Salah Ameen Abdu , Wenjie Li , Yunqi Li , Yunhong Lin , Chun Yang , Xingxing Li","doi":"10.1016/j.jdsr.2025.10.002","DOIUrl":"10.1016/j.jdsr.2025.10.002","url":null,"abstract":"<div><h3>Background</h3><div>Oral health impairments may compromise dietary intake and increase malnutrition risk in older adults. This review quantified associations between oral health indicators and malnutrition risk while synthesizing qualitative evidence.</div></div><div><h3>Methods</h3><div>Following PRISMA 2020 guidelines, we searched five databases for systematic reviews examining oral health indicators and nutritional outcomes in older adults. Quality was assessed using the JBI Critical Appraisal Checklist. RevMan 5.4 was used for meta-analyses, with sensitivity analyses using Comprehensive Meta-Analysis v3.7.</div></div><div><h3>Results</h3><div>Sixteen systematic reviews (518,647 participants) were included. Functional problems (chewing difficulty, xerostomia) were more associated with malnutrition than structural indicators, and while edentulism was frequently related to increased risk, dentures showed mixed correlations. Meta-analysis showed malnutrition risk was associated with masticatory dysfunction (RR) (1.75; p = 0.0001) and edentulism without dentures (RR) (1.71; p < 0.0005), but not with dental prostheses (RR) (1.01; p = 0.96); tooth count showed no significant association (MD) (-0.16; p = 0.19).</div></div><div><h3>Conclusions</h3><div>Functional oral impairment, particularly masticatory dysfunction and edentulism without dentures is more likely associated with malnutrition. Routine integration of oral and nutritional screening in geriatric care is warranted, with standardized measures needed to clarify the impact of salivary function and prosthetic rehabilitation on nutritional outcomes.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 264-279"},"PeriodicalIF":6.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the optimal concentration of carbamide peroxide for at-home bleaching? A systematic review and network meta-analysis 家用漂白的最佳过氧化脲浓度是多少？系统回顾和网络荟萃分析

IF 6.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-10-30 DOI: 10.1016/j.jdsr.2025.10.001

Deisy Cristina Ferreira Cordeiro , Romina Ñaupari-Villasante , Letícia Caroline Condolo , Renata Maria Oleniki Terra , Michael Willian Favoreto , Juliana Larocca de Geus , Ana Claudia Chibinski , Alessandra Reis

This study represents the first network meta-analysis (NMA) comparing the efficacy and safety of different concentrations of carbamide peroxide (CP) for at-home bleaching in permanent dentition. A comprehensive search was conducted across PubMed, Cochrane Central, LILACS/BBO, SCOPUS, Web of Science, EMBASE, and gray literature. Randomized controlled trials (RCTs) comparing at least two CP concentrations were included. Color change (ΔE, ΔSGU), risk and intensity of tooth sensitivity TS was assessed Cochrane RoB 2.0 and GRADE were used to evaluate the risk of bias (RoB) and certainty of evidence. Thirteen RCTs were included, most with high RoB. CP5 % and 37 % appeared in a single trial each. For ΔSGU, no significant differences were detected between concentrations. For ΔE, all concentrations were superior to CP 5 %, with the largest difference observed for CP 37 %; intermediate concentrations showed minimal variations. Regarding TS, CP10 % was associated with a 67 % lower risk compared to CP 20–22 % (RR 1.67; 95 % CrI: 1.15–2.57), and CP 20–22 % also caused significantly higher TS intensity on the NRS scale. Conclusion: Lower concentrations of CP reduced the risk of TS while achieving bleaching efficacy comparable to higher concentrations, suggesting that less concentrated gels is safer and effective for at-home bleaching.

本研究是第一个网络荟萃分析（NMA），比较了不同浓度过氧化脲（CP）在永久牙列家庭漂白中的有效性和安全性。在PubMed、Cochrane Central、LILACS/BBO、SCOPUS、Web of Science、EMBASE和灰色文献中进行了全面的检索。纳入了比较至少两种CP浓度的随机对照试验（rct）。采用Cochrane RoB 2.0和GRADE评价偏倚风险（RoB）和证据确定性。纳入13项随机对照试验，大多数罗伯值较高。CP5 %和37 %分别出现在单次试验中。对于ΔSGU，不同浓度间未检测到显著差异。对于ΔE，所有浓度均优于CP 5 %，其中CP 37 %差异最大；中间浓度变化极小。对于TS，与CP 20-22 %相比，CP10 %与67 %的风险降低相关（RR 1.67; 95 % CrI: 1.15-2.57），并且CP 20-22 %也导致NRS量表上TS强度显著升高。结论：较低浓度的CP降低了TS的风险，同时达到了与较高浓度相当的漂白效果，这表明较低浓度的CP对于家庭漂白更安全有效。

{"title":"What is the optimal concentration of carbamide peroxide for at-home bleaching? A systematic review and network meta-analysis","authors":"Deisy Cristina Ferreira Cordeiro , Romina Ñaupari-Villasante , Letícia Caroline Condolo , Renata Maria Oleniki Terra , Michael Willian Favoreto , Juliana Larocca de Geus , Ana Claudia Chibinski , Alessandra Reis","doi":"10.1016/j.jdsr.2025.10.001","DOIUrl":"10.1016/j.jdsr.2025.10.001","url":null,"abstract":"<div><div>This study represents the first network meta-analysis (NMA) comparing the efficacy and safety of different concentrations of carbamide peroxide (CP) for at-home bleaching in permanent dentition. A comprehensive search was conducted across PubMed, Cochrane Central, LILACS/BBO, SCOPUS, Web of Science, EMBASE, and gray literature. Randomized controlled trials (RCTs) comparing at least two CP concentrations were included. Color change (ΔE, ΔSGU), risk and intensity of tooth sensitivity TS was assessed Cochrane RoB 2.0 and GRADE were used to evaluate the risk of bias (RoB) and certainty of evidence. Thirteen RCTs were included, most with high RoB. CP5 % and 37 % appeared in a single trial each. For ΔSGU, no significant differences were detected between concentrations. For ΔE, all concentrations were superior to CP 5 %, with the largest difference observed for CP 37 %; intermediate concentrations showed minimal variations. Regarding TS, CP10 % was associated with a 67 % lower risk compared to CP 20–22 % (RR 1.67; 95 % CrI: 1.15–2.57), and CP 20–22 % also caused significantly higher TS intensity on the NRS scale. Conclusion: Lower concentrations of CP reduced the risk of TS while achieving bleaching efficacy comparable to higher concentrations, suggesting that less concentrated gels is safer and effective for at-home bleaching.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 250-263"},"PeriodicalIF":6.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0