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Effects of phototherapy in patients with idiopathic facial palsy: Scoping review 光疗对特发性面瘫患者的影响:范围界定综述
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-05 DOI: 10.1016/j.jdsr.2024.09.001
Keita Takizawa , Kana Ozasa , Akiko Shimada , Toru Ogawa , Takashi Iida , Yuka Oono , Keiichi Sasaki , Noboru Noma
Phototherapy has emerged as a promising treatment for Bell’s palsy, offering potential improvements in facial nerve function and overall well-being. In this study, we selected seven relevant studies involving 306 patients with subacute or acute Bell’s palsy from PubMed, EMBASE, Web of Science, and Scopus before June 5, 2024. Low-level laser therapy (LLLT) efficacy for facial nerve paralysis was assessed in seven studies. Two studies lacked standard deviation data, precluding meta-analysis. Sunnybrook scores favored LLLT (mean difference [MD] = 17.42, 95 % confidence interval [CI]: 4.00–30.84, p = 0.011). However, Facial Disability Index results showed no significant difference (MD = 12.16, 95 % CI: −0.60 to 24.92, p = 0.061) between LLLT and control. LLLT, particularly with wavelengths of 830 or 850 nm administered over 6 weeks, may lead to beneficial outcomes. Combining LLLT with exercise therapy appears to be effective.LLLT demonstrates promise as a management option for Bell’s palsy, potentially offering advantages over other treatments, particularly in patients with comorbidities, such as diabetes. Phototherapy devices currently used in Japan offer non-invasive treatment with minimal patient burden. The safety and therapeutic efficacy of these devices have been confirmed as a potential treatment for facial nerve paralysis.
光疗已成为治疗贝尔氏麻痹的一种很有前景的方法,可改善面神经功能和整体健康。在本研究中,我们从 2024 年 6 月 5 日之前的 PubMed、EMBASE、Web of Science 和 Scopus 中选择了 7 项相关研究,涉及 306 名亚急性或急性贝尔麻痹患者。七项研究对低强度激光疗法(LLLT)治疗面神经麻痹的疗效进行了评估。其中两项研究缺乏标准偏差数据,因此无法进行荟萃分析。桑尼布鲁克评分倾向于 LLLT(平均差 [MD] = 17.42,95% 置信区间 [CI]:4.00-30.84, p = 0.011).然而,面部残疾指数结果显示,LLLT 和对照组之间没有明显差异(MD = 12.16,95 % 置信区间:-0.60 至 24.92,p = 0.061)。LLLT,尤其是波长为 830 或 850 nm、持续 6 周的 LLLT,可能会带来有益的结果。将 LLLT 与运动疗法相结合似乎是有效的。LLLT 作为一种治疗贝尔氏麻痹的方法前景广阔,与其他治疗方法相比可能更具优势,尤其是对糖尿病等合并症患者。日本目前使用的光疗设备提供非侵入性治疗,患者负担最小。这些设备的安全性和疗效已得到证实,是治疗面神经麻痹的潜在方法。
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引用次数: 0
Enamel matrix derivative monotherapy versus combination therapy with bone grafts for periodontal intrabony defects: An updated review 牙周骨内缺损的釉质基质衍生物单一疗法与植骨联合疗法对比:最新综述
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-23 DOI: 10.1016/j.jdsr.2024.08.001
Akira Hasuike , Taito Watanabe , Akemu Hirooka , Shingi Arai , Hideyasu Akutagawa , Naoto Yoshinuma , Shuichi Sato
This systematic review evaluated the effectiveness of combining enamel matrix derivative (EMD) with various bone grafts in periodontal regenerative surgery, specifically targeting intrabony defects. Randomized controlled trials with 12-month follow-ups were included. Clinical outcomes assessed included clinical attachment level, probing depth, gingival recession, and radiographic defect fill. Meta-analysis showed that adding bone grafts to EMD does not provide additional benefits in periodontal tissue examination, with improvement observed only in radiographic defect fill. Subgroup analyses examined the impact of different bone graft types, revealing that alloplastic bone grafts are effective in radiographic defect fill. The risk of bias assessment indicated a moderate risk across studies, with challenges in blinding owing to the nature of the surgical treatment. Furthermore, a minimal intervention surgical approach may not require additional bone grafts for optimal periodontal regeneration. These findings contribute to the ongoing dialogue in the field and guide clinicians toward evidence-based decisions for optimal periodontal outcomes, emphasizing the judicious use of bone grafts.
本系统性综述评估了在牙周再生手术中将釉基质衍生物(EMD)与各种骨移植相结合的效果,特别是针对骨内缺损的效果。研究纳入了随访 12 个月的随机对照试验。评估的临床结果包括临床附着水平、探诊深度、牙龈退缩和放射学缺陷填充。Meta 分析表明,在 EMD 中添加植骨并不能为牙周组织检查带来额外的益处,只有在放射学缺损填充方面才能观察到改善。亚组分析研究了不同植骨类型的影响,发现异体骨移植对放射学缺陷填充有效。偏倚风险评估显示,各项研究均存在中度偏倚风险,由于手术治疗的性质,在盲法方面存在挑战。此外,最小干预手术方法可能不需要额外的骨移植就能达到最佳牙周再生效果。这些研究结果为该领域的持续对话做出了贡献,并指导临床医生做出以证据为基础的决定,以获得最佳的牙周效果,同时强调了骨移植的明智使用。
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引用次数: 0
Associations between metabolic disorders and Sjögren's disease 代谢紊乱与斯约戈伦病之间的关系
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-21 DOI: 10.1016/j.jdsr.2024.06.002
Chihiro Iwaya , Junichi Iwata
Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.
斯约格伦病(Sjögren's disease,SjD)是一种全身性自身免疫性疾病,其特征是慢性炎症引起的眼干和口干,通常伴有各种腺体外表现,包括疲劳和弥漫性疼痛。虽然该病的发病机制仍然难以捉摸,但有几种因素(如环境、遗传和激素因素、异常代谢状态)与此病有关。越来越多的证据表明,胆固醇代谢在各种疾病的免疫和非免疫调节中发挥着潜在的作用。在这篇综述中,我们总结了目前关于胆固醇代谢与 SjD 之间关系的研究结果。
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引用次数: 0
Optimal storage time and temperature of human oral samples to minimize microbiome changes: A scoping review 人类口腔样本的最佳储存时间和温度,以尽量减少微生物组的变化:范围审查
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-20 DOI: 10.1016/j.jdsr.2024.05.001
Hyun Ju Kim , Dong Hyun Park , Seung Hyun Han , Sun-Young Kim
Improper storage times and temperatures negatively impact the quality of biospecimens with oral microbiomes. This study aimed to determine the optimal storage time and temperature for maintaining the integrity of human dental plaque and saliva samples' microbial profiles. A comprehensive search yielded 5433 studies, with 12 meeting inclusion criteria. The number of studies on the storage time and temperature for plaque or saliva samples was extremely limited, with large variability in study designs and analytical tools. The best approach for dental plaque and saliva samples was to immediately freeze fresh specimens at − 80 °C or lower until DNA extraction, with a recommended storage time not exceeding 1–2 years, regardless of temperature. Checkerboard DNA-DNA hybridization-based studies suggested dental plaque storage at − 20 °C for 6 months, but a shorter duration was advised. Based on 16 S rRNA gene sequencing studies, dental plaque samples could be stored at − 80 °C for 6 months in 75 % ethanol or Bead Solution. Dental plaque and saliva samples could be stored at room temperature for 1–2 weeks without significant microbiome changes if stored in appropriate media. Further well-designed randomized controlled studies with longer-storage duration are necessary to establish more definitive guidelines.
储存时间和温度不当会对口腔微生物组生物样本的质量产生负面影响。本研究旨在确定保持人类牙菌斑和唾液样本微生物图谱完整性的最佳储存时间和温度。通过全面搜索,共获得 5433 项研究,其中 12 项符合纳入标准。关于牙菌斑或唾液样本储存时间和温度的研究数量极其有限,而且研究设计和分析工具也存在很大差异。牙菌斑和唾液样本的最佳方法是立即将新鲜样本冷冻在零下 80 摄氏度或更低的温度下,直至提取 DNA,无论温度如何,建议储存时间不超过 1-2 年。基于棋盘式DNA-DNA杂交的研究建议牙菌斑在-20 °C下保存6个月,但也有建议缩短保存时间的。根据 16 S rRNA 基因测序研究,牙菌斑样本可在 75% 乙醇或 Bead 溶液中于 - 80 °C 下保存 6 个月。如果将牙菌斑和唾液样本保存在适当的培养基中,可在室温下保存 1-2 周,微生物组不会发生明显变化。有必要进一步开展设计良好的随机对照研究,延长储存时间,以制定更明确的指导原则。
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引用次数: 0
Current trends in digital shade matching – A scoping review 数字色调匹配的当前趋势 - 范围审查
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-19 DOI: 10.1016/j.jdsr.2024.10.001
Vaishnavi M. Nayak, Kavishma Sulaya, Swapna Bettanapalya Venkatesh
Shade selection plays an important role in the success of any prosthesis and is largely influenced by technological advancements and societal trends, which emphasize the need for accurate shade selection. This scoping review aims to assess the accuracy of shade matching with any of the digital shade selection methods compared to the conventional method. This review employs PRISMA extension protocols for scoping review and search strategies based on keywords performed in PubMed, Scopus, and Cochrane databases. Two investigators (V.N. and S.B.V.) independently performed screening of the literature electronically in three databases. In vivo and in vitro studies which used digital shade selection methods were included in the study. A total of 29 articles which had used any method of digital shade selection were assessed. This scoping review concluded that the reliability and accuracy of various digital methods were comparable to that of conventional methods. Further research is suggested for the development of standalone, reliable and accurate methods for the use of digital shade analysis.
色调选择对任何假体的成功都起着重要作用,并在很大程度上受到技术进步和社会趋势的影响,这些都强调了准确选择色调的必要性。本范围性综述旨在评估与传统方法相比,任何一种数字色调选择方法的色调匹配准确性。本综述采用 PRISMA 扩展协议进行范围界定综述,并根据关键字在 PubMed、Scopus 和 Cochrane 数据库中执行搜索策略。两位研究者(V.N.和 S.B.V.)独立在三个数据库中进行了电子文献筛选。使用数字阴影选择方法的体内和体外研究被纳入研究范围。共评估了 29 篇使用任何数字色调选择方法的文章。这次范围审查得出的结论是,各种数字方法的可靠性和准确性与传统方法相当。建议进一步研究开发独立、可靠和准确的数字遮光分析方法。
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引用次数: 0
Effect of hydrofluoric acid and self-etch ceramic primers on the flexural strength and fatigue resistance of glass ceramics: A systematic review and meta-analysis of in vitro studies 氢氟酸和自酸蚀陶瓷底漆对玻璃陶瓷抗弯强度和抗疲劳性的影响:体外研究的系统回顾和荟萃分析
IF 5.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-24 DOI: 10.1016/j.jdsr.2024.06.001
Paulo Matias Moreira, Gabriela Luiza Moreira Carvalho, Rodrigo de Castro Albuquerque, Carolina Bosso André

This systematic review evaluated the effect of different hydrofluoric acid (HF) etching regimens and a self-etch ceramic primer (SECP) on the flexural strength (FS) and fatigue failure load (FFL) of glass-ceramic materials.The identification of relevant studies was conducted by two authors in five databases: PubMED, Scopus, Web Of Science, LILACS and Virtual Health Library (BVS) until July 2022 with no year limit. The analysis was conducted in RevMan 5.4.1 Software (Cochrane Collaboration) using Random effect model at 5 %. The risk of bias of the included studies were assessed. From the 5349 articles identified, 34 were included for quantitative analysis. Meta-analysis showed that for predominantly glassy ceramics, etching with HF 5 % had no significant impact on FS, however, HF acid etching with concentrations greater than 5 % negatively impacted FS. For lithium disilicate glass-ceramics (LDGC) HF acid etching, negatively influenced FS, while increasing the FFL. HF etching negatively affected FS of hybrid ceramics. The self-etch ceramic primer and HF acid etching showed a similar impact on FFL and FS. This meta-analysis indicates that the impact of SECP and HF acid etching on the mechanical behavior of glass ceramics is material-dependent.

本系统综述评估了不同氢氟酸(HF)蚀刻方案和自蚀刻陶瓷底漆(SECP)对玻璃陶瓷材料抗弯强度(FS)和疲劳破坏载荷(FFL)的影响:两位作者在以下五个数据库中查找了相关研究:PubMED、Scopus、Web Of Science、LILACS 和 Virtual Health Library (BVS),截止日期为 2022 年 7 月,无年份限制。分析在 RevMan 5.4.1 软件(Cochrane Collaboration)中进行,采用随机效应模型(5%)。对纳入研究的偏倚风险进行了评估。在确定的 5349 篇文章中,有 34 篇被纳入进行定量分析。元分析表明,对于以玻璃为主的陶瓷,使用浓度为 5% 的高频酸蚀刻对 FS 没有显著影响,但浓度大于 5% 的高频酸蚀刻对 FS 有负面影响。对于二硅酸锂玻璃陶瓷(LDGC),高频酸蚀刻会对 FS 产生负面影响,同时会增加 FFL。高频酸蚀对混合陶瓷的 FS 有负面影响。自刻蚀陶瓷底漆和高频酸蚀刻对 FFL 和 FS 的影响相似。这项荟萃分析表明,SECP 和高频酸蚀刻对玻璃陶瓷机械性能的影响取决于材料。
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引用次数: 0
Clinical use of duplicate complete dentures: A narrative review 复制全口义齿的临床使用:叙述性综述
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-14 DOI: 10.1016/j.jdsr.2024.05.005
Nobuhiro Yoda , Masumi Abe , Hirofumi Yamaguchi , Naomi Tanoue , Tetsuo Yamamori

Most reports on duplicate dentures are introduction to fabrication methods or clinical case reports. Only a few studies have verified their clinical effectiveness; hence, evidence to construct useful clinical guidelines for duplicate denture use is lacking. This review aimed to comprehensively investigate reports on duplicate dentures to accumulate evidences that will contribute to the formulation of clinical practice guidelines. Duplicate dentures are effectively used for impression making and bite registration when fabricating new dentures, thereby reducing the number of clinic visits and treatment time. Duplicate denture can also be used as temporary or new dentures. Older people in whom various adaptive abilities have declined, may find it difficult to adjust to new dentures and experience stress, even if the shape is appropriate. Duplicate dentures, which reproduces the shape of old dentures that they are used to, have the advantage of being more familiar to older people and less stressful. When manufacturing duplicate dentures, digital methods such as milling and three-dimensional printing are superior to conventional methods regarding working time and cost. A notable advantage of the digital method is that the denture shape can be saved as digital data, and the denture can be easily duplicated if lost.

大多数关于重复义齿的报道都是介绍制作方法或临床病例报告。只有少数研究验证了它们的临床有效性;因此,缺乏证据来为重复义齿的使用制定有用的临床指南。本综述旨在全面调查有关复式义齿的报告,以积累有助于制定临床实践指南的证据。制作新义齿时,复制义齿可有效用于印模和咬合登记,从而减少就诊次数和治疗时间。复制义齿还可用作临时义齿或新义齿。各种适应能力下降的老年人可能难以适应新假牙,即使假牙形状合适,也会感到紧张。复制假牙可以再现老年人习惯的旧假牙形状,其优点是老年人更熟悉,压力更小。在制作复型假牙时,铣削和三维打印等数字化方法在工作时间和成本方面都优于传统方法。数字化方法的一个显著优势是可以将假牙形状保存为数字化数据,如果丢失,可以很容易地复制假牙。
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引用次数: 0
Different surface treatments and adhesive monomers for zirconia-resin bonds: A systematic review and network meta-analysis 氧化锆-树脂粘接的不同表面处理和粘接单体:系统综述和网络荟萃分析
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-07 DOI: 10.1016/j.jdsr.2024.05.004
Xinyang Li , Shengjie Liang , Masanao Inokoshi , Shikai Zhao , Guang Hong , Chenmin Yao , Cui Huang

This review examined the efficacy of surface treatments and adhesive monomers for enhancing zirconia-resin bond strength. A comprehensive literature search in PubMed, Embase, Web of Science, Scopus, and the Cochrane Library yielded relevant in vitro studies. Employing pairwise and Bayesian network meta-analyses, 77 articles meeting inclusion criteria were analyzed. Gas plasma was found to be ineffective, while treatments including air abrasion, silica coating, laser, selective infiltration etching, hot etching showed varied effectiveness. Air abrasion with finer particles (25–53 µm) showed higher immediate bond strength than larger particles (110–150 µm), with no significant difference post-aging. The Rocatec silica coating system outperformed the CoJet system in both immediate and long-term bond strength. Adhesives containing 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) were superior to other acidic monomers. The application of 2-hydroxyethyl methacrylate and silane did not improve bonding performance. Notably, 91.2 % of bonds weakened after aging, but this effect was less pronounced with air abrasion or silica coating. The findings highlight the effectiveness of air abrasion, silica coating, selective infiltration etching, hot etching, and laser treatment in improving bond strength, with 10-MDP in bonding agents enhancing zirconia bonding efficacy.

本综述研究了表面处理和粘合剂单体在增强氧化锆-树脂粘接强度方面的功效。通过对 PubMed、Embase、Web of Science、Scopus 和 Cochrane 图书馆进行全面的文献检索,得出了相关的体外研究结果。通过配对分析和贝叶斯网络荟萃分析,对符合纳入标准的 77 篇文章进行了分析。结果发现,气体等离子体的效果不佳,而包括气磨、二氧化硅涂层、激光、选择性浸润蚀刻和热蚀刻在内的处理方法则显示出不同的效果。与较大的颗粒(110-150 微米)相比,使用较细颗粒(25-53 微米)的气磨显示出更高的即时粘接强度,但老化后没有显著差异。Rocatec 二氧化硅涂层系统的即时和长期粘接强度均优于 CoJet 系统。含有 10-甲基丙烯酰氧癸基磷酸二氢酯(10-MDP)的粘合剂优于其他酸性单体。使用甲基丙烯酸 2-羟乙基酯和硅烷并不能提高粘接性能。值得注意的是,91.2% 的粘接剂在老化后会变弱,但这种影响在空气磨蚀或硅涂层中并不明显。研究结果凸显了空气研磨、二氧化硅涂层、选择性渗透蚀刻、热蚀刻和激光处理在提高粘接强度方面的有效性,粘接剂中的 10-MDP 可提高氧化锆的粘接效果。
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引用次数: 0
The clinical efficacy of powder air-polishing in the non-surgical treatment of peri-implant diseases: A systematic review and meta-analysis 气垫粉末在非手术治疗种植体周围疾病中的临床疗效:系统回顾与荟萃分析
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-22 DOI: 10.1016/j.jdsr.2024.05.003
Nengwen Huang , Yang Li , Huachen Chen , Wen Li , Chengchaozi Wang , YanJing OU , Masahiro Likubo , Jiang Chen

Peri-implant diseases, characterized by inflammatory conditions affecting peri-implant tissues, encompass peri-implant mucositis and peri-implantitis. Peri-implant mucositis is an inflammatory lesion limited to the mucosa around an implant, while peri-implantitis extends from the mucosa to the supporting bone, causing a loss of osseointegration. For non-surgical treatments, we tested the null hypothesis that the presence or absence of air-polishing made no difference. The study focused on randomized controlled trials (RCTs) comparing air-polishing with mechanical or ultrasonic debridement, evaluating outcomes such as bleeding on probing (BOP), probing depth (PD), plaque index/plaque score (PI/PS), clinical attachment level (CAL), bone loss, and mucosal recession (MR). Two independent reviewers conducted data extraction and quality assessments, considering short-term (<6 months) and long-term (≥6 months) follow-up periods. After screening, ten articles were included in the meta-analysis. In nonsurgical peri-implant disease management, air-polishing moderately mitigated short-term PI/PS for peri-implant mucositis and showed a similar improvement in long-term BOP and bone loss for peri-implantitis compared to the control group. The Egger test found no evidence of publication bias except for the long-term PI/PS of peri-implant mucositis. Leave-one-out analysis confirmed the stability of the results. The findings highlight the need for future research with longer-term follow-up and high-quality, multi-center, large-sample RCTs.

种植体周围疾病的特征是影响种植体周围组织的炎症,包括种植体周围粘膜炎和种植体周围炎。种植体周围粘膜炎是局限于种植体周围粘膜的炎性病变,而种植体周围炎则从粘膜延伸到支撑骨,导致骨结合丧失。对于非手术治疗方法,我们检验了有无空气抛光没有区别的零假设。研究重点是比较空气抛光与机械或超声波清创的随机对照试验(RCT),评估的结果包括探诊出血(BOP)、探诊深度(PD)、牙菌斑指数/牙菌斑评分(PI/PS)、临床附着水平(CAL)、骨质流失和粘膜萎缩(MR)。两位独立审稿人在考虑短期(6 个月)和长期(≥6 个月)随访期的情况下进行了数据提取和质量评估。经过筛选,十篇文章被纳入荟萃分析。在非手术治疗种植体周围疾病方面,与对照组相比,空气抛光可适度减轻种植体周围粘膜炎的短期PI/PS,并对种植体周围炎的长期BOP和骨质流失有类似的改善作用。除了种植体周围粘膜炎的长期 PI/PS 外,Egger 检验没有发现发表偏倚的证据。留空分析证实了结果的稳定性。研究结果突出表明,今后的研究需要更长期的随访和高质量、多中心、大样本的 RCT。
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引用次数: 0
Caries preventive potential of professionally deliverable fluoride-containing agents with incorporated arginine: A scoping review 含有精氨酸的专业给药含氟制剂的龋齿预防潜力:范围审查
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-22 DOI: 10.1016/j.jdsr.2024.05.002
Nouf Ali Alblooshi , Tiba Kahtan Naseer , Mohammed Nadeem Bijle

The scoping review objectives were to: 1) investigate the caries preventive potential of professionally deliverable fluoride (F)-containing agents with incorporated arginine (Arg); and 2) identify the future scope of research on Arg-F interventions for caries prevention. Of 150 identified records, 7 articles (6 in vitro investigations and 1 scoping review) were included for a complete review; with no clinical studies with/without appraisal. Arginine variants (L-Arg/Arg.HCl at 1% to 10% w/v.) were examined for a potential professional application aimed at caries prevention, as reported with in vitro studies. Of the included articles, four in vitro studies explored L-Arg enriched 5% NaF varnish (Duraphat®) as a promising caries preventive agent, while only one considered incorporating L-Arg in MI varnish®/nanohydroxyapatite and one investigated glass ionomer cement for primary/secondary and tertiary caries prevention. The scoping review highlighted the scope for incorporating Arg to professionally deliverable F-containing agents. No clinical data are available to make conclusive recommendations about the caries preventive potential of professionally deliverable F-containing agents with incorporated Arg. With Arg-F varnish being investigated predominantly through in vitro studies, the data so far suggest that Arg was incorporated exclusively in Duraphat®, while the potential of Arg to prevent caries in other F-containing varnishes remains unexplored.

范围界定审查的目标是1)研究含有精氨酸(Arg)的专业递送型含氟(F)制剂的龋齿预防潜力;以及 2)确定 Arg-F 预防龋齿干预措施的未来研究范围。在已确定的 150 份记录中,有 7 篇文章(6 篇体外调查和 1 篇范围审查)被纳入完整审查;没有进行临床研究,也没有进行评估。根据体外研究报告,对精氨酸变体(L-Arg/Arg.HCl,1%-10% w/v.)进行了检查,以了解其在预防龋齿方面的潜在专业应用。在收录的文章中,有四项体外研究探讨了将富含 L-Arg 的 5%NaF清漆(Duraphat®)作为一种很有前景的龋病预防剂,只有一项研究考虑了将 L-Arg 加入 MI 清漆®/纳米羟基磷灰石中,还有一项研究调查了用于一级/二级和三级预防龋病的玻璃离聚体水泥。范围界定审查强调了将 Arg 加入可专业递送的含氟制剂的范围。目前还没有临床数据可以对添加了 Arg 的专业含氟牙剂的龋齿预防潜力提出结论性建议。Arg-F清漆主要通过体外研究进行调查,迄今为止的数据表明,Arg仅被纳入Duraphat®中,而Arg在其他含氟清漆中预防龋齿的潜力仍有待探索。
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Japanese Dental Science Review
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