Prevalence and Mortality Rates of Acute Kidney Injury among Critically Ill Patients: A Retrospective Study.

IF 1.8 Q3 CRITICAL CARE MEDICINE Critical Care Research and Practice Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI:10.1155/2023/9966760
Randa I Farah, Othman A Alfuqaha, Ali R Younes, Hasan A Mahmoud, Alhareth M Al-Jboor, Mohammad M Karajeh, Mohammad Z Al-Masadeh, Omar I Murad, Nathir Obeidat
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Abstract

Acute kidney injury (AKI) poses a significant challenge in critically ill patients. To determine the prevalence, risk factors, and mortality rate of AKI among nonsurgical critically ill patients in Jordan University Hospital, we conducted a retrospective study using a consecutive sampling method, including 457 nonsurgical critically ill patients admitted to the medical intensive care unit (MICU) from January to June 2021. The mean age was 63.8 ± 18 years, with 196 (42.8%) developing AKI during their stay in the MICU. Among AKI nonsurgical patients, pulmonary diseases (n = 52; 34.5%) emerged as the primary cause for admission, exhibiting the highest prevalence, followed by sepsis (n = 40; 20.4%). Furthermore, we found that older age (adjusted OR (AOR): 1.04; 95% confidence interval (CI): 1.04-1.06; p = 0.003), preadmission use of diuretics (AOR: 2.12; 95% CI: 1.06-4.25; p = 0.03), use of ventilators (2.19; 95% CI: 1.12-2.29; p = 0.02), and vasopressor use during MICU stay (AOR: 4.25; 95% CI: 2.1308.47; p = 0.001) were observed to have higher mortality rates. Prior utilization of statins before admission exhibited a significant association with reduced mortality rate (AOR: 0.42; 95% CI: 0.2-0.85; p = 0.02). Finally, AKI was associated with a higher mortality rate during MICU stay (AOR: 2.44; 95% CI: 1.07-5.56; p = 0.03). The prevalence of AKI among nonsurgical patients during MICU stay is higher than what has been reported previously in the literature, which highlights the nuanced importance of identifying more factors contributing to AKI in developing countries, and hence providing preventive measures and adhering to global strategies are recommended.

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危重患者急性肾损伤的患病率和死亡率:一项回顾性研究。
急性肾损伤(AKI)对危重患者提出了重大挑战。为了确定约旦大学医院非手术重症患者AKI的患病率、危险因素和死亡率,我们采用连续抽样的方法进行了一项回顾性研究,纳入了2021年1月至6月入住医学重症监护病房(MICU)的457名非手术重症患者。平均年龄为63.8±18岁,其中196例(42.8%)在住院期间发生AKI。在AKI非手术患者中,肺部疾病(n = 52;34.5%)是入院的主要原因,患病率最高,其次是脓毒症(n = 40;20.4%)。此外,我们发现老年人(调整后的OR (AOR): 1.04;95%置信区间(CI): 1.04-1.06;p = 0.003),入院前使用利尿剂(AOR: 2.12;95% ci: 1.06-4.25;P = 0.03),呼吸机使用率(2.19;95% ci: 1.12-2.29;p = 0.02),以及MICU住院期间血管加压药物的使用情况(AOR: 4.25;95% ci: 2.1308.47;P = 0.001)死亡率较高。入院前是否使用他汀类药物与降低死亡率显著相关(AOR: 0.42;95% ci: 0.2-0.85;P = 0.02)。最后,AKI与MICU住院期间较高的死亡率相关(AOR: 2.44;95% ci: 1.07-5.56;P = 0.03)。MICU住院期间非手术患者AKI患病率高于先前文献报道,这突出了在发展中国家确定更多导致AKI的因素的微妙重要性,因此建议提供预防措施并坚持全球策略。
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来源期刊
Critical Care Research and Practice
Critical Care Research and Practice CRITICAL CARE MEDICINE-
CiteScore
3.60
自引率
0.00%
发文量
34
审稿时长
14 weeks
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