Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review.

IF 3.2 Q2 GENETICS & HEREDITY Epigenetics Insights Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI:10.1177/25168657231213195

Eiman M Mohammed

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Abstract

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS that affects millions of people worldwide. The causes of the disease remain unknown despite extensive efforts to understand it. CircRNAs are a unique class of endogenous non-coding RNA that are abundant, stable, conserved, and specifically expressed molecules, making them a promising biomarker of diseases. This review investigates the role of circRNA in MS pathogenicity and their potential as a biomarker through a comprehensive literature search conducted in 8 scientific databases. The studies found that there are differentially expressed circRNAs in MS patients compared to healthy controls (HC), and this difference is even more pronounced in different MS subtypes. Enrichment of circRNAs in linkage disequilibrium (LD) blocks that harbor MS-associated SNPs suggests that these SNPs manipulate the levels of circRNAs in the surrounding area, contributing to disease pathogenicity. While circRNA shows promise as an indicator or biomarker for MS disease pathology, further research is needed to fully explore its potential and impact on human biology.

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环状RNA在多发性硬化症中的作用:致病性和潜在的生物标志物开发:系统综述。

多发性硬化症(MS)是一种复杂的中枢神经系统自身免疫性疾病，影响着全世界数百万人。尽管人们做了大量努力来了解这种疾病，但病因仍不清楚。CircRNAs是一类独特的内源性非编码RNA，数量丰富、稳定、保守且特异性表达，使其成为一种有希望的疾病生物标志物。本文通过对8个科学数据库的全面文献检索，探讨了circRNA在MS致病性中的作用及其作为生物标志物的潜力。研究发现，与健康对照(HC)相比，MS患者中存在差异表达的环状rna，这种差异在不同的MS亚型中更为明显。在含有ms相关SNPs的连锁不平衡(LD)块中，环状rna的富集表明，这些SNPs操纵周围区域的环状rna水平，有助于疾病的致病性。虽然circRNA有望成为MS疾病病理的指标或生物标志物，但还需要进一步的研究来充分挖掘其潜力和对人类生物学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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