Fanny Villoz , Tommaso Filippini , Natalia Ortega , Doris Kopp-Heim , Trudy Voortman , Manuel R. Blum , Cinzia Del Giovane , Marco Vinceti , Nicolas Rodondi , Patricia O. Chocano-Bedoya
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引用次数: 0
Abstract
Dairy intake may influence cognition through several molecular pathways. However, epidemiologic studies yield inconsistent results, and no dose-response meta-analysis has been conducted yet.
Therefore, we performed a systematic review with a dose-response meta-analysis about the association between dairy intake and cognitive decline or incidence of dementia.
We investigated prospective studies with a follow-up ≥6 mo on cognitive decline or dementia incidence in adults without known chronic conditions through a systematic search of Embase, Medline, Cochrane Library, Web of Science, and Google Scholar from inception to 11 July 2023. We evaluated the dose-response association using a random-effects model.
We identified 15 eligible cohort studies with >300,000 participants and a median follow-up of 11.4 y. We observed a negative nonlinear association between cognitive decline/dementia incidence and dairy intake as assessed through the quantity of consumption, with the nadir at ∼150 g/d (risk ratio: 0.88; 95% confidence interval: 0.78, 0.99). Conversely, we found an almost linear negative association when we considered the frequency of consumption (risk ratio for linear trend: 0.84; 95% confidence interval: 0.77, 0.92 for 1 time/d increase of dairy products). Stratified analysis by dairy products showed different shapes of the association with linear inverse relationship for milk intake, whereas possibly nonlinear for cheese. The inverse association was limited to Asian populations characterized by generally lower intake of dairy products, compared with the null association reported by European studies.
In conclusion, our study suggests a nonlinear inverse association between dairy intake and cognitive decline or dementia, also depending on dairy types and population characteristics, although the heterogeneity was still high in overall and several subgroup analyses. Additional studies should be performed on this topic, including a wider range of intake and types of dairy products, to confirm a potential preventing role of dairy intake on cognitive decline and identify ideal intake doses.
This review was registered at PROSPERO as CRD42020192395.
背景:乳制品摄入可能通过几种分子途径影响认知。然而，流行病学研究得出的结果不一致，尚未进行剂量-反应荟萃分析。目的:我们对乳制品摄入与认知能力下降或痴呆发病率之间的关系进行了一项剂量反应荟萃分析的系统评价。方法:我们通过系统检索Embase、Medline、Cochrane图书馆、Web of Science和Google Scholar，从成立到2023年7月11日，对无已知慢性疾病的成人认知能力下降或痴呆发病率进行了前瞻性研究，随访≥6个月。我们使用随机效应模型评估剂量-反应关联。结果:我们确定了15项符合条件的队列研究，参与者超过30万，中位随访11.4年。我们观察到认知能力下降/痴呆发病率与乳制品摄入量呈非线性负相关，最低为150克/天(RR=0.88, 95% CI 0.78-0.99)。相反，当我们考虑消费频率时，我们发现几乎呈线性负相关(线性趋势的RR为0.84，每天增加一次乳制品的95% CI为0.77-0.92)。乳制品的分层分析显示，牛奶摄入量呈不同形状的线性反比关系，而奶酪摄入量可能呈非线性关系。与欧洲研究报告的零关联相比，这种负相关仅限于以乳制品摄入量普遍较低为特征的亚洲人群。结论:我们的研究表明，乳制品摄入量与认知能力下降或痴呆之间存在非线性负相关，这也取决于乳制品类型和人群特征，尽管总体和几个亚组分析的异质性仍然很高。应该对这一主题进行更多的研究，包括更广泛的乳制品摄入量和种类，以确认乳制品摄入对认知能力下降的潜在预防作用，并确定理想的摄入剂量。普洛斯彼罗的注册号码:CRD42020192395。意义声明:本系统综述和荟萃分析确定了15项评估乳制品对认知功能作用的前瞻性观察性研究。我们的研究结果表明，乳制品可能与认知能力下降或痴呆的风险较低有关，但这种关系似乎是非线性的，也与性别、年龄、原产地区、摄入水平和乳制品类型的差异有关。
期刊介绍：
Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments.
In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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