Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review

IF 6.1 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Nutrition Pub Date : 2023-12-04 DOI:10.1016/j.aninu.2023.12.001

Pengju Wang, Lv-hui Sun, Xu Wang, Qinghua Wu, Aimei Liu

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Abstract

T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing. Therefore, suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue. Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature, but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized. In this review, we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects. Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option. This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

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T-2毒素器官毒性的有效保护剂及其解毒机制综述

T-2毒素是食品和饲料中分布最广、毒性最强的真菌毒素之一。对人和动物可引起胃肠道毒性、肝毒性、免疫毒性、生殖毒性、神经毒性和肾毒性。T-2毒素具有物理化学稳定性，在食品和饲料加工过程中不易降解。因此，通过解毒剂抑制T-2毒素诱导的器官毒性是一个迫切的问题。抗T-2毒素器官毒性的保护物质在文献中有广泛的报道，但这些保护物质及其解毒的分子机制尚未得到全面的总结。本文就T-2毒素的各种保护剂及其解毒作用的分子机制作一综述。选择合适的靶点拮抗T-2毒素毒性也是一个重要的选择。本文综述将为今后更好地应用和开发器官毒性特异性T-2毒素解毒剂提供必要的指导和策略。

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来源期刊

Animal Nutrition Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

7.40

自引率

3.20%

发文量

172

审稿时长

12 weeks

期刊介绍： Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to nutrition, and more applied aspects of animal nutrition, such as raw material evaluation, feed additives, nutritive value of novel ingredients and feed safety.