Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study.

IF 3.4 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Clinical Epidemiology Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI:10.2147/CLEP.S427881

Oh Chan Kwon, Kyungdo Han, Min-Chan Park

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Abstract

Background and aims: Lipid metabolism is altered in systemic sclerosis (SSc), mediating activation of immune cells and fibroblasts. However, it is unclear whether altered lipid profile is associated with a risk of developing SSc. We aimed to assess the association between lipid profile and risk of incident SSc.

Methods: From a Korean nationwide database, individuals without SSc who underwent national health check-ups in 2009 were selected and followed-up through 2019. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride were measured on the health check-up date in 2009. Individuals who developed SSc during follow-up were identified. Multivariable Cox models were performed to estimate the risk of incident SSc according to TC, HDL-C, LDL-C, and triglyceride levels, respectively.

Results: Of the 9,894,996 individuals selected, 1355 individuals developed SSc during a mean follow-up of 9.2 years (incidence rate=1.49 per 100,000 person-years). Levels of TC (adjusted hazard ratio [aHR] 0.959, 95% confidence interval [CI] 0.945-0.974), HDL-C (aHR 0.968, 95% CI 0.950-0.987), LDL-C (aHR 0.968, 95% CI 0.952-0.983) were inversely associated with the risk of incident SSc, whereas no significant association was observed between levels of triglyceride (aHR 1.004, 95% CI 0.998-1.011) and risk of incident SSc.

Conclusion: Serum levels of TC, HDL-C, and LDL-C were inversely associated with the risk of incident SSc. Our findings provide new insights that altered lipid profile could be considered a non-causal biomarker associated with incident SSc, which could help early diagnosis. The underlying mechanism for this association needs further studies.

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血脂与系统性硬化症发生风险之间的关系:一项基于全国人群的研究

背景和目的:脂质代谢在系统性硬化症(SSc)中发生改变，介导免疫细胞和成纤维细胞的激活。然而，目前尚不清楚脂质谱的改变是否与发生SSc的风险相关。我们的目的是评估血脂与SSc发生风险之间的关系。方法:从韩国全国数据库中选择2009年接受全国健康检查的无SSc个体，并随访至2019年。2009年体检时测定血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和甘油三酯水平。在随访期间确定了发展为SSc的个体。采用多变量Cox模型，分别根据TC、HDL-C、LDL-C和甘油三酯水平估计SSc发生的风险。结果:在所选择的9,894,996个个体中，1355个个体在平均9.2年的随访期间发生了SSc(发病率=1.49 / 100,000人年)。TC(校正风险比[aHR] 0.959, 95%可信区间[CI] 0.945-0.974)、HDL-C (aHR 0.968, 95% CI 0.950-0.987)、LDL-C (aHR 0.968, 95% CI 0.952-0.983)水平与SSc发生风险呈负相关，而甘油三酯水平(aHR 1.004, 95% CI 0.998-1.011)与SSc发生风险无显著相关性。结论:血清TC、HDL-C和LDL-C水平与SSc发生风险呈负相关。我们的发现提供了新的见解，即脂质谱的改变可以被认为是与SSc事件相关的非因果生物标志物，这可能有助于早期诊断。这种关联的潜在机制需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology Medicine-Epidemiology

CiteScore

6.30

自引率

5.10%

发文量

169

审稿时长

16 weeks

期刊介绍： Clinical Epidemiology is an international, peer reviewed, open access journal. Clinical Epidemiology focuses on the application of epidemiological principles and questions relating to patients and clinical care in terms of prevention, diagnosis, prognosis, and treatment. Clinical Epidemiology welcomes papers covering these topics in form of original research and systematic reviews. Clinical Epidemiology has a special interest in international electronic medical patient records and other routine health care data, especially as applied to safety of medical interventions, clinical utility of diagnostic procedures, understanding short- and long-term clinical course of diseases, clinical epidemiological and biostatistical methods, and systematic reviews. When considering submission of a paper utilizing publicly-available data, authors should ensure that such studies add significantly to the body of knowledge and that they use appropriate validated methods for identifying health outcomes. The journal has launched special series describing existing data sources for clinical epidemiology, international health care systems and validation studies of algorithms based on databases and registries.