Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2023-12-01 DOI:10.1016/j.pacs.2023.100578

Adrian P. Regensburger , Markus Eckstein , Matthias Wetzl , Roman Raming , Lars-Philip Paulus , Adrian Buehler , Emmanuel Nedoschill , Vera Danko , Jörg Jüngert , Alexandra L. Wagner , Alexander Schnell , Aline Rückel , Ulrich Rother , Oliver Rompel , Michael Uder , Arndt Hartmann , Markus F. Neurath , Joachim Woelfle , Maximilian J. Waldner , André Hoerning , Ferdinand Knieling

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Abstract

Multispectral optoacoustic tomography (MSOT) allows non-invasive molecular disease activity assessment in adults with inflammatory bowel disease (IBD). In this prospective pilot-study, we investigated, whether increased levels of MSOT haemoglobin parameters corresponded to inflammatory activity in paediatric IBD patients, too. 23 children with suspected IBD underwent MSOT of the terminal ileum and sigmoid colon with standard validation (e.g. endoscopy). In Crohn`s disease (CD) and ulcerative colitis (UC) patients with endoscopically confirmed disease activity, MSOT total haemoglobin (HbT) signals were increased in the terminal ileum of CD (72.1 ± 13.0 a.u. vs. 32.9 ± 15.4 a.u., p = 0.0049) and in the sigmoid colon of UC patients (62.9 ± 13.8 a.u. vs. 35.1 ± 16.3 a.u., p = 0.0311) as compared to controls, respectively. Furthermore, MSOT haemoglobin parameters correlated well with standard disease activity assessment (e.g. SES-CD and MSOT HbT (r_s =0.69, p = 0.0075). Summarizing, MSOT is a novel technology for non-invasive molecular disease activity assessment in paediatric patients with inflammatory bowel disease.

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多光谱光声断层扫描能够评估儿童炎症性肠病的疾病活动性

多光谱光声断层扫描(MSOT)可以对成人炎症性肠病(IBD)进行非侵入性分子疾病活动评估。在这项前瞻性试点研究中，我们调查了MSOT血红蛋白参数水平的升高是否也与儿科IBD患者的炎症活动相对应。23名疑似IBD的儿童接受了标准验证(如内窥镜检查)的回肠末端和乙状结肠MSOT。在内镜下确认疾病活动性的克罗恩病(CD)和溃疡性结肠炎(UC)患者中，与对照组相比，CD患者回肠末端的MSOT总血红蛋白(HbT)信号分别升高(72.1±13.0 a.u. vs. 32.9±15.4 a.u.， p = 0.0049)和UC患者的b状结肠(62.9±13.8 a.u. vs. 35.1±16.3 a.u.， p = 0.0311)。此外，MSOT血红蛋白参数与标准疾病活动性评估(如SES-CD和MSOT HbT)相关性良好(rs =0.69, p = 0.0075)。综上所述，MSOT是一种对儿童炎症性肠病患者进行无创分子疾病活动性评估的新技术。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.