Cell and tissue-based models for evaluating the cutaneous impact of visible light

Abstract

Owing to its low energy, visible light (VIS) was previously considered to have no photobiological effects and research was focused on the ultraviolet (UV) end of the solar spectrum. However, the discovery that exposure of skin to VIS leads to clinical changes in skin reminiscent of those of UV led to a reassessment of its effects. Driving our understanding have been cell and tissue-based models that permit a thorough dissection of the molecular events in skin cells following exposure to specific wavelengths and intensities of VIS. Here we explore how these models have been used to understand the cutaneous impact of VIS and identify substances that protect skin from its damaging effects.