Current status and future of gene engineering in livestock.

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY BMB Reports Pub Date : 2024-01-01
Dong-Hyeok Kwon, Gyeong-Min Gim, Soo-Young Yum, Goo Jang
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Abstract

The application of gene engineering in livestock is necessary for various reasons, such as increasing productivity and producing disease resistance and biomedicine models. Overall, gene engineering provides benefits to the agricultural and research aspects, and humans. In particular, productivity can be increased by producing livestock with enhanced growth and improved feed conversion efficiency. In addition, the application of the disease resistance models prevents the spread of infectious diseases, which reduces the need for treatment, such as the use of antibiotics; consequently, it promotes the overall health of the herd and reduces unexpected economic losses. The application of biomedicine could be a valuable tool for understanding specific livestock diseases and improving human welfare through the development and testing of new vaccines, research on human physiology, such as human metabolism or immune response, and research and development of xenotransplantation models. Gene engineering technology has been evolving, from random, time-consuming, and laborious methods to specific, time-saving, convenient, and stable methods. This paper reviews the overall trend of genetic engineering technologies development and their application for efficient production of genetically engineered livestock, and provides examples of technologies approved by the United States (US) Food and Drug Administration (FDA) for application in humans. [BMB Reports 2024; 57(1): 50-59].

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家畜基因工程的现状与未来。
基因工程在家畜中的应用是必要的,原因有很多,如提高生产率、产生抗病能力和生物医学模型。总之,基因工程对农业、科研和人类都有好处。特别是,通过培育生长速度更快、饲料转化效率更高的家畜,可以提高生产率。此外,抗病模型的应用可防止传染病的传播,从而减少治疗的需要,如抗生素的使用;因此,它能促进畜群的整体健康,减少意外的经济损失。生物医学的应用可以通过开发和测试新疫苗、研究人体生理(如人体新陈代谢或免疫反应)以及研究和开发异种移植模型,成为了解特定牲畜疾病和改善人类福利的重要工具。基因工程技术一直在不断发展,从随机、耗时、费力的方法发展到特异、省时、方便、稳定的方法。本文回顾了基因工程技术发展的总体趋势及其在高效生产基因工程牲畜方面的应用,并提供了美国食品药品管理局(FDA)批准应用于人类的技术实例。
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来源期刊
BMB Reports
BMB Reports 生物-生化与分子生物学
CiteScore
5.10
自引率
7.90%
发文量
141
审稿时长
1 months
期刊介绍: The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.
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