Pain management in zebrafish : Report from a FELASA Working Group.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Laboratory Animals Pub Date : 2024-06-01 Epub Date: 2023-12-05 DOI:10.1177/00236772231198733
Lynne U Sneddon, Paul Schroeder, Ana Roque, Karin Finger-Baier, Angeleen Fleming, Simon Tinman, Bertrand Collet
{"title":"Pain management in zebrafish : Report from a FELASA Working Group.","authors":"Lynne U Sneddon, Paul Schroeder, Ana Roque, Karin Finger-Baier, Angeleen Fleming, Simon Tinman, Bertrand Collet","doi":"10.1177/00236772231198733","DOIUrl":null,"url":null,"abstract":"<p><p>Empirical evidence suggests fishes meet the criteria for experiencing pain beyond a reasonable doubt and zebrafish are being increasingly used in studies of pain and nociception. Zebrafish are adopted across a wide range of experimental fields and their use is growing particularly in biomedical studies. Many laboratory procedures in zebrafish involve tissue damage and this may give rise to pain. Therefore, this FELASA Working Group reviewed the evidence for pain in zebrafish, the indicators used to assess pain and the impact of a range of drugs with pain-relieving properties. We report that there are several behavioural indicators that can be used to determine pain, including reduced activity, space use and distance travelled. Pain-relieving drugs prevent these responses, and we highlight the dose and administration route. To minimise or avoid pain, several refinements are suggested for common laboratory procedures. Finally, practical suggestions are made for the management and alleviation of pain in laboratory zebrafish, including recommendations for analgesia. Pain management is an important refinement in experimental animal use and so our report has the potential to improve zebrafish welfare during and after invasive procedures in laboratories across the globe.</p>","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264547/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Animals","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00236772231198733","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Empirical evidence suggests fishes meet the criteria for experiencing pain beyond a reasonable doubt and zebrafish are being increasingly used in studies of pain and nociception. Zebrafish are adopted across a wide range of experimental fields and their use is growing particularly in biomedical studies. Many laboratory procedures in zebrafish involve tissue damage and this may give rise to pain. Therefore, this FELASA Working Group reviewed the evidence for pain in zebrafish, the indicators used to assess pain and the impact of a range of drugs with pain-relieving properties. We report that there are several behavioural indicators that can be used to determine pain, including reduced activity, space use and distance travelled. Pain-relieving drugs prevent these responses, and we highlight the dose and administration route. To minimise or avoid pain, several refinements are suggested for common laboratory procedures. Finally, practical suggestions are made for the management and alleviation of pain in laboratory zebrafish, including recommendations for analgesia. Pain management is an important refinement in experimental animal use and so our report has the potential to improve zebrafish welfare during and after invasive procedures in laboratories across the globe.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
斑马鱼的疼痛管理:FELASA 工作组的报告。
经验证据表明,鱼类毫无疑问符合体验疼痛的标准,斑马鱼正越来越多地被用于疼痛和痛觉研究。斑马鱼被广泛地应用于各个实验领域,尤其是在生物医学研究中,斑马鱼的应用日益广泛。斑马鱼的许多实验过程都涉及组织损伤,这可能会引起疼痛。因此,FELASA 工作组审查了斑马鱼疼痛的证据、用于评估疼痛的指标以及一系列具有止痛特性的药物的影响。我们报告说,有几种行为指标可用于确定疼痛,包括活动减少、空间利用和行走距离。镇痛药物可以防止这些反应,我们还强调了剂量和给药途径。为了最大限度地减少或避免疼痛,我们对常见的实验室程序提出了一些改进建议。最后,我们就如何管理和减轻实验斑马鱼的疼痛提出了实用建议,包括镇痛建议。疼痛管理是实验动物使用过程中的一项重要改进,因此我们的报告有可能改善全球实验室中斑马鱼在侵入性操作过程中和操作后的福利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
期刊最新文献
An innovative approach for health and safety training and occupational health program annual enrollment for laboratory animal care and use personnel. Extended oxygen supplementation after thoracotomy in rats may improve welfare. Animal researchers' views on the publication of negative results and subsequent policy adoptions. Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1