A Randomized Controlled Pilot Study Exploring the Additive Clinical Effect of Cognitive Bias Modification-Memory in Depressed Inpatients

IF 2.8 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Cognitive Therapy and Research Pub Date : 2023-11-22 DOI:10.1007/s10608-023-10452-y
Janna N. Vrijsen, Hanah Windbergs, Eni S. Becker, Norbert Scherbaum, Bernhard W. Müller, Indira Tendolkar
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Abstract

Background

Depression often leads to clinical admission. Stimulating positive memory bias through repeated retrieval can counteract a ruminative depressotypic processing style. Cognitive Bias Modification (CBM)-Memory is a psychological intervention, which was evaluated as possible adjunct treatment for depressed inpatients.

Methods

A randomized controlled pilot study with a one-week follow-up was implemented to compare the effect of a four-session positive CBM-Memory intervention to a neutral CBM-Memory version. Training-congruent retrieval (as manipulation check), and transfer to rumination (as mechanistic target) and depressive symptoms (self-rated and clinician-rated; indication of clinical relevance) were assessed.

Results

In the intention-to-treat sample (N = 81, Mage=35.6/SD = 11.9, 60% female), condition-congruent memory retrieval of previously presented target words was found after the training and at follow-up (large effect-sizes). Positive CBM-Memory intervention resulted in sustained recall bias and largest rumination reduction with a small-medium effect size. Additionally, the conditions did not differ significantly on the reduction in depressive symptoms.

Conclusions

Positive CBM-Memory intervention yielded positive recall bias, which was still present one week later. Additionally, the positive condition did yield more decrease in trait (but not state) rumination, providing some support for rumination as mechanistic target of positive CBM-Memory. However, there was no evidence for transfer of the training effect to depressive symptoms, indicating no superiority on clinical recovery of the positive over the neutral condition. Future research should examine a higher dosage, integration of CBM in the treatment provision, and its long-term effects in a well-powered trial.

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一项探讨抑郁症住院患者认知偏差修正记忆的附加临床效应的随机对照先导研究
背景:抑郁症经常导致临床入院。通过重复检索刺激积极记忆偏差可以抵消反刍抑郁型加工方式。认知偏差修正记忆是一种心理干预,可作为抑郁症住院患者的辅助治疗方法。方法采用一项随机对照先导研究,为期一周的随访,比较四期阳性cbm -记忆干预与中性cbm -记忆干预的效果。训练一致性检索(作为操作检查)、反刍转移(作为机械性目标)和抑郁症状(自评和临床评定);临床相关指征)进行评估。结果意向处理样本(N = 81, Mage=35.6/SD = 11.9,女性占60%)在训练结束后和随访时均能获得目标词语的条件一致记忆(效应量较大)。积极的cbm -记忆干预导致持续回忆偏差和最大的反刍减少,具有中小型效应量。此外,两种情况在减轻抑郁症状方面没有显著差异。结论正向cbm -记忆干预产生正向回忆偏倚,且在一周后仍存在。此外,积极条件确实导致特质反刍(而不是状态反刍)的减少,这为反刍作为积极cbm -记忆的机制目标提供了一定的支持。然而,没有证据表明训练效应会转移到抑郁症状上,这表明在临床恢复上,阳性条件并不比中性条件有优势。未来的研究应该检查更高的剂量,在治疗提供中整合CBM,以及在一个强有力的试验中其长期效果。
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来源期刊
Cognitive Therapy and Research
Cognitive Therapy and Research PSYCHOLOGY, CLINICAL-
CiteScore
5.30
自引率
0.00%
发文量
52
期刊介绍: Cognitive Therapy and Research (COTR) focuses on the investigation of cognitive processes in human adaptation and adjustment and cognitive behavioral therapy (CBT). It is an interdisciplinary journal welcoming submissions from diverse areas of psychology, including cognitive, clinical, developmental, experimental, personality, social, learning, affective neuroscience, emotion research, therapy mechanism, and pharmacotherapy.
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