Plasma-activated medium induces apoptosis in chemotherapy-resistant ovarian cancer cells: High selectivity and synergy with carboplatin

Abstract

This corrigendum corrects the following published paper:

Milad Rasouli, Hassan Mehdian, Kamal Hajisharifi, Elaheh Amini, Kostya (Ken) Ostrikov, Eric Robert (First published July 09, 2021) Plasma-activated medium induces apoptosis in chemotherapy-resistant ovarian cancer cells: High selectivity and synergy with carboplatin. Plasma Processes Polym. 2021; 18:2100074. https://doi.org/10.1002/ppap.202100074.

We would like to correct the confusing last sentence of Sec. 2.11 and replace three out of thirty images in Figure 3. The last sentence in this section gives a confusing impression regarding why deep anesthesia was needed if cells were extracted from dead mice. We aim to eliminate this ambiguity in the last sentence of Section 2.11. Unfortunately, an unexpected issue arose during the preparation phase, resulting in duplicate images within the composite figures due to image naming discrepancies. This error occurred in Figure 3a (PAM (60 s) AO/PI, PAM (60 s) + CAR (H&E)) and Figure 3c (PAM (60 s) AO/PI). We have now rectified this issue and presented the corrected figure in this corrigendum.

Figure 3

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(a) AO/PI staining and H&E staining of GC cells; (b) AO/PI staining and H&E staining of A2780 CP cells; (c) AO/PI staining and H&E staining of SKOV-3 cells. AO/PI, acridine orange/propidium iodide; CAR, carboplatin; CTRL, control; GC, granulosa cell; H&E, hematoxylin and eosin; PAM, plasma-activated medium.

Last sentence of Section 2.11: The mice underwent deep anesthesia before being killed, and all surgical procedures were conducted with utmost care to minimize any potential suffering. Subsequently, cell extraction was carried out following the detailed protocol outlined in Section A.3 of the Supplementary Information.

The updated figure is provided below:

It should be noted that the replaced photos are from the same batch of experiments as all other experiments in the rest of the figure, and all original photos and lab records were double-checked carefully. We would like to assure you that this correction does not impact the overall results or conclusions of our study. We apologize for any confusion or inconvenience caused by this error.