Comparison of respiratory and cardiovascular effects of halothane, isoflurane, and enflurane delivered via the Jackson-Rees breathing system in rats. New anaesthesia model for small animal surgery.

E Dárdai, J E Heavner
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Abstract

We studied the respiratory (R) and cardiovascular (CV) effects of 1.25 MAC halothane (H), isoflurane (I) and enflurane (E) in oxygen, delivered by the Jackson-Rees breathing system in 5 normothermic rats. Mean arterial pressure (MAP), heart rate (HR) were depressed after 30 minutes than stabilized after 2 hours anaesthesia regardless of the inhalational agent. Respiratory rate (RR) slowed down markedly unter I and E anaesthesia. Significant R depression was developed (PCO2 53.5 +/- 2.44 Torr) under E. Stabil metabolic condition was maintained. The R and CV changes caused by H and I were far less than changes produced by E. H or I is preferable to E for small animal anaesthesia with spontaneous breathing. Maintenance of constant temperature minimizes the CV and R disturbances.

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Jackson-Rees呼吸系统给药氟烷、异氟烷和安氟烷对大鼠呼吸和心血管影响的比较小动物手术麻醉新模型。
研究了Jackson-Rees呼吸系统给氧1.25 MAC氟烷(H)、异氟烷(I)和安氟烷(E)对5只常温大鼠呼吸(R)和心血管(CV)的影响。麻醉30分钟后平均动脉压(MAP)、心率(HR)下降,麻醉2小时后稳定。I、E麻醉下呼吸频率(RR)明显减慢。e组R显著降低(PCO2 53.5 +/- 2.44 Torr),代谢状态保持稳定。H和I引起的R和CV变化远小于E引起的变化。对于自主呼吸的小动物麻醉,H或I优于E。保持恒温可以使CV和R的干扰降到最低。
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