[The effect of hydrocortisone and dopamine on the activity of some lysosomal liver enzymes in experimental endotoxic shock].

L Trochimowicz, Z Puchalski, J Barczyk, J R Ladny
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Abstract

The influence of hydrocortisone and dopamine to the course of the organic functional changes and the activity of same lysosomal hepatic enzymes were tested in 30 dogs in endotoxic shock. A continuous lowering of the blood pressure and the central venous pressure were observed in the non-treated group. The hemodynamic impairments turned out in the treated groups in a less acute course. The coupled treatment with hydrocortisone and dopamine in the experimental endotoxic shock seems to reduce the activity of the lysosomal enzymes in the liver and in the peripheral blood.

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[氢化可的松和多巴胺对实验性内源性休克中溶酶体肝酶活性的影响]。
采用内源性休克30只狗,测定了氢化可的松和多巴胺对肝组织有机功能变化过程和同一溶酶体肝酶活性的影响。未治疗组血压和中心静脉压持续下降。治疗组出现血流动力学损伤的急性病程较轻。氢化可的松和多巴胺联用治疗实验性内源性休克似乎可以降低肝脏和外周血中溶酶体酶的活性。
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