Production of Auger-electron-emitting 103mRh via a 103Pd/103mRh generator using an anion-exchange resin

IF 1.4 3区 化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR Radiochimica Acta Pub Date : 2023-11-22 DOI:10.1515/ract-2023-0238
Tomoyuki Ohya, Jun Ichinose, Kotaro Nagatsu, Yumi Sugo, Noriko Ishioka, Hiroshi Watabe, Masatoshi Itoh, Katsuyuki Minegishi, Ming-Rong Zhang
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Abstract

Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of 103mRh is relatively short (56.114 min). Therefore, it needs to be produced using a generator for clinical use. Most studies of 103Pd/103mRh generators using anion-exchange resins were carried out over 50 years ago. However, these resins are no longer commercially available. In the present study, we tested a 103Pd/103mRh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added 103Pd was used to make the generators. The 103mRh product was eluted from the generators using 6 mL of 0.1 M HCl with a flow rate 0.5 mL/min. The generator made from SA11AL showed good performance, with a yield of 39 %, an impurity level of 103Pd in the product of 0.29 %, and an operation time of 14 min. This makes this generator competitive with previously developed ones.
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利用阴离子交换树脂通过103Pd/103mRh发生器产生103mRh的俄歇电子
铑-103m是最具吸引力的内部放射治疗俄歇电子发射体之一。103mRh的半衰期相对较短(56.114 min)。因此,需要使用发生器生产用于临床。大多数使用阴离子交换树脂的103Pd/103mRh发电机的研究是在50多年前进行的。然而,这些树脂已不再在市场上销售。在本研究中,我们使用替代阴离子交换树脂(即IRA904, IRA410, SA20A和SA11AL)测试了103Pd/103mRh发生器。发生器采用无载流子添加的103Pd。103mRh产物用6ml 0.1 M HCl以0.5 mL/min的流速从发生器中洗脱。用SA11AL制备的发生器性能良好,产率为39%,产物中杂质含量为103Pd,为0.29%,运行时间为14 min,具有较好的竞争力。
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来源期刊
Radiochimica Acta
Radiochimica Acta 化学-核科学技术
CiteScore
2.90
自引率
16.70%
发文量
78
审稿时长
6 months
期刊介绍: Radiochimica Acta publishes manuscripts encompassing chemical aspects of nuclear science and technology.
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