Polyoxometalates as next-generation of theragnostic gadgets in cancer

IF 4.1 3区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Reviews in Inorganic Chemistry Pub Date : 2023-12-04 DOI:10.1515/revic-2023-0008
Fahimeh Aminolroayaei, Ali Mehri, Daryoush Shahbazi-Gahrouei, Mahboubeh Rostami
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Abstract

Polyoxometalates (POMS) are a class of mineral clusters of transition metals or rare-earth elements linked together by Oxo ligands. POMs have been identified as antibacterial, antiviral, and anticancer agents after decades of research since the onset of the 20th century. Furthermore, in recent years POMs have been studied for their applications in diagnosis, photodynamic therapy, photothermal therapy, and theragnostic. However, these last-mentioned POM applications have rarely been reviewed. Considering the potential characteristic features of POMs, comprising their easy, inexpensive, and scalable synthesis, and with special attention to the challenges of their application, POMs would be great alternatives to many conventional medical tools in the field of cancer treatment and diagnosis. In this review, we report recent updated research around utilizing POMs in cancer diagnosis and theragnostic. Publications are on basic topics including POMs in magnetic resonance imaging (MRI), POMs in computed tomography (CT), POMs in cancer photoluminescence (PL) imaging, POMs in multimodality, POMs in radiation therapy applications, POMs as radiosensitizer and promotor of drug release, and POMs in theragnostic applications. It is hoped that this review paper will be useful for those researchers who are interested in expanding the applications of polyoxometalates in the field of cancer treatment and diagnosis.
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多金属氧酸盐作为新一代癌症诊断工具
多金属氧酸盐(POMS)是一类由氧配体连接在一起的过渡金属或稀土元素的矿物簇。自20世纪初以来,经过几十年的研究,聚甲醛已被确定为抗菌、抗病毒和抗癌药物。此外,近年来pom在诊断、光动力治疗、光热治疗和诊断等方面的应用也得到了广泛的研究。然而,这些最后提到的POM应用程序很少被审查。考虑到POMs的潜在特征,包括其简单、廉价和可扩展的合成,并特别注意其应用中的挑战,POMs将成为癌症治疗和诊断领域许多传统医疗工具的重要替代品。在这篇综述中,我们报告了最近关于利用聚甲醛在癌症诊断和治疗中的最新研究。出版物的基本主题包括POMs在磁共振成像(MRI)中的应用,POMs在计算机断层扫描(CT)中的应用,POMs在癌症光致发光(PL)成像中的应用,POMs在多模态中的应用,POMs在放射治疗中的应用,POMs作为放射增敏剂和药物释放促进剂的应用,以及POMs在治疗中的应用。希望本文能对有意拓展多金属氧酸盐在癌症治疗和诊断领域应用的研究人员有所帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in Inorganic Chemistry
Reviews in Inorganic Chemistry 化学-分析化学
CiteScore
7.30
自引率
4.90%
发文量
20
审稿时长
1 months
期刊介绍: Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids
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