Efficacy of catheter-based drug delivery in a hybrid in vitro model of cardiac microvascular obstruction with porcine microthrombi

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL Bioengineering & Translational Medicine Pub Date : 2023-12-08 DOI:10.1002/btm2.10631
Yannick Rösch, Thorald Stolte, Miriam Weisskopf, Sabrina Frey, Rob Schwartz, Nikola Cesarovic, Dominik Obrist
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Abstract

Microvascular obstruction (MVO) often occurs in ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Diagnosis and treatment of MVO lack appropriate and established procedures. This study focused on two major points by using an in vitro multiscale flow model, which comprised an aortic root model with physiological blood flow and a microfluidic model of the microcirculation with vessel diameters down to 50 μm. First, the influence of porcine microthrombi (MT), injected into the fluidic microchip, on perfusion was investigated. We found that only 43 % of all injected MT were fully occlusive. Second, it could also be shown that the maximal concentration of a dye (representing therapeutic agent) during intracoronary infusion could be increased on average by 58 % , when proximally occluding the coronary artery by a balloon during drug infusion. The obtained results and insights enhance the understanding of perfusion in MVO-affected microcirculation and could lead to improved treatment methods for MVO patients.

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在猪微血栓心脏微血管阻塞混合体外模型中导管给药的功效
经皮冠状动脉介入治疗(PCI)后,ST 段抬高型心肌梗死(STEMI)患者常会出现微血管阻塞(MVO)。MVO 的诊断和治疗缺乏适当的既定程序。本研究采用体外多尺度血流模型,包括具有生理血流的主动脉根部模型和血管直径小至 50 μm 的微循环微流控模型,重点研究了两个要点。首先,研究了注入流体微芯片的猪微血栓(MT)对灌注的影响。我们发现,在所有注入的 MT 中,只有 43%$$ 43%\$$ 是完全闭塞的。其次,还可以证明,在冠状动脉内输注药物时,如果用球囊近端堵塞冠状动脉,染料(代表治疗药物)的最大浓度平均可提高 58%。所获得的结果和见解加深了人们对受 MVO 影响的微循环灌注的理解,并可改进 MVO 患者的治疗方法。
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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