Nutritional neurology: Unraveling cellular mechanisms of natural supplements in brain health

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2023-12-05 DOI:10.1016/j.hnm.2023.200232
Suraj Kumar, Rishabha Malviya, Sonali Sundram
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Abstract

The consequence of appropriate food consumption and the corresponding amount of dietary nutrients on brain function is widely recognized. More and more studies are pointing to the importance of diet for alleviating neurological symptoms associated with a wide range of clinical disorders. The recently discovered implications of nutritional variables on modifications in mitochondrial dysfunction, epigenetic modification, and neurological inflammation represent important factors that play a crucial role in determining the effect of nutrition on Neuronal (health). This overview investigates the present state of evidence regarding the efficacy of various dietary interventions, such as dietary supplements and dietary restrictions, for in the context of managing disorders related to the brain. Particularly, it clearly state the consequences of these interventions on conditions such as Alzheimer's, Parkinson's, ischemic stroke, seizures, injury to the brain, amyotrophic lateral sclerosis (ALL), Huntington's syndrome, and multiple sclerosis (MS). Along with this, it is important to note that a variety of possible processes, such as metabolic regulation, epigenetic alteration, and the inflammation of neurons assume a pivotal function. in determining the impact of nutrition availability on the risk of neurologic conditions and treatment outcomes. Along with this, authors clearly state the innovative concept that dietary supplement intervention can modify interconnected processes of metabolism, epigenetics, and immunology, thereby addressing brain dysfunction. Concentrating on metabolic processes the study of the epigenetic-immunity network has the potential to provide a novel framework for addressing vulnerabilities in the field of neurology.

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营养神经学:揭示天然保健品促进大脑健康的细胞机制
适当的食物摄入量和相应的膳食营养素含量对大脑功能的影响已得到广泛认可。越来越多的研究指出,饮食对于缓解与多种临床疾病相关的神经症状非常重要。最近发现的营养变量对线粒体功能障碍、表观遗传修饰和神经系统炎症的影响是决定营养对神经元(健康)影响的重要因素。本综述研究了目前有关各种膳食干预措施(如膳食补充剂和膳食限制)在控制大脑相关疾病方面的功效的证据。特别是,它清楚地说明了这些干预措施对阿尔茨海默氏症、帕金森氏症、缺血性中风、癫痫发作、脑损伤、肌萎缩性脊髓侧索硬化症(ALL)、亨廷顿综合症和多发性硬化症(MS)等疾病的影响。此外,需要注意的是,各种可能的过程,如新陈代谢调节、表观遗传改变和神经元炎症等,在决定营养供应对神经系统疾病风险和治疗效果的影响方面起着举足轻重的作用。此外,作者还明确提出了一个创新概念,即膳食补充剂干预可以改变代谢、表观遗传学和免疫学等相互关联的过程,从而解决大脑功能障碍问题。对表观遗传学-免疫学网络的研究集中于新陈代谢过程,有可能为解决神经学领域的弱点提供一个新的框架。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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