Human Nutrition and Metabolism最新文献

Impact of resistance, endurance, and combined exercise training on lipid profile, apolipoprotein A-1, and nitric oxide synthase expression in women with type 2 diabetes: A randomized controlled trial 抵抗、耐力和联合运动训练对2型糖尿病女性血脂、载脂蛋白A-1和一氧化氮合酶表达的影响：一项随机对照试验

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2026-01-29 DOI: 10.1016/j.hnm.2026.200360

Bagher Shojah-anzabi , Reza Farzizadeh , Farnaz Seifi-asgshahr , Afshin Nejati-afkham

Background

Type 2 diabetes mellitus (T2DM) involves metabolic disturbances and endothelial dysfunction, raising cardiovascular risk.

Objective

To compare the effects of 8 weeks of resistance, endurance, and combined exercise on serum apolipoprotein A-1 (ApoA1), lipid profile, nitric oxide (NO) levels, nitric oxide synthase (NOS) expression, and metabolic parameters in women with T2DM.

Methods

Sixty women with T2DM (aged 48–58) were randomized into resistance, endurance, combined training, or control groups. Interventions occurred thrice weekly for eight weeks. Pre- and post-intervention measures included anthropometrics (weight, BMI, WHR), fasting blood glucose (FBS), HbA1c, lipid profile (TG, LDL, HDL, total cholesterol), ApoA1, NO levels, and NOS expression (iNOS, eNOS).

Results

All exercise groups showed significant metabolic improvements versus controls. Endurance training notably reduced FBS, triglycerides, and BMI, with greatest improvements in FBS and TG (p < 0.05). Resistance training yielded the largest decreases in weight (12.89 %) and BMI (8.12 %), while combined training most effectively lowered FBS (19.23 %). The endurance group had the greatest HbA1c reduction (18.15 %). No significant changes were found in ApoA1, LDL, HDL, or total cholesterol. NO levels increased significantly in all exercise groups, especially combined and resistance groups (p < 0.001), but iNOS and eNOS expression remained unchanged. Controls showed minimal change.

Conclusion

Eight weeks of resistance, endurance, or combined exercise improve metabolic markers in women with T2DM, each with distinct benefits. Increased NO without NOS expression changes suggests alternative pathways for NO bioavailability. Tailored exercise regimens are recommended for optimal T2DM management and cardiovascular risk reduction.

背景2型糖尿病（T2DM）涉及代谢紊乱和内皮功能障碍，增加心血管风险。目的比较8周抵抗、耐力和联合运动对2型糖尿病女性血清载脂蛋白A-1 （ApoA1）、血脂、一氧化氮（NO）水平、一氧化氮合酶（NOS）表达和代谢参数的影响。方法60例48 ~ 58岁的2型糖尿病女性患者随机分为抵抗组、耐力组、联合训练组和对照组。干预每周进行三次，持续八周。干预前和干预后的测量包括人体测量（体重、BMI、WHR）、空腹血糖（FBS）、HbA1c、血脂（TG、LDL、HDL、总胆固醇）、ApoA1、NO水平和NOS表达（iNOS、eNOS）。结果：与对照组相比，所有运动组均表现出显著的代谢改善。耐力训练显著降低了FBS、甘油三酯和BMI，其中FBS和TG的改善最大（p <； 0.05）。阻力训练对体重（12.89 %）和BMI（8.12 %）的降低效果最大，而联合训练对FBS（19.23 %）的降低效果最好。耐力组的HbA1c降低幅度最大（18.15% %）。ApoA1、LDL、HDL或总胆固醇均未见显著变化。在所有运动组中，NO水平显著升高，尤其是联合运动组和抵抗运动组（p <； 0.001），但iNOS和eNOS表达保持不变。对照组的变化很小。结论：8周的抵抗、耐力或联合运动可改善T2DM女性的代谢指标，各有不同的益处。NO升高而不改变NOS表达提示NO生物利用度的其他途径。推荐量身定制的运动方案，以达到最佳的T2DM管理和心血管风险降低。

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引用次数: 0

Universal salt iodization remains insufficient to prevent iodine deficiency without maternal education and improved household salt practices: insights from structural equation modelling in Noakhali 如果没有母亲教育和改善家庭食盐习惯，普遍食盐加碘仍然不足以预防碘缺乏症：Noakhali结构方程模型的见解

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-12-09 DOI: 10.1016/j.hnm.2025.200359

Umma Faria Rika , Mohammad Asadul Habib , Prantu Sen , Ricvan Dana Nindrea , Long Chiau Ming

Background

Despite decades of universal salt iodization (USI), iodine deficiency remains a persistent public health problem in Bangladesh, mainly impacting children in rural and socioeconomically disadvantaged communities.

Methods

A cross-sectional survey of 400 children (6–12 years) in four upazilas of Noakhali measured UIC using the Sandell–Kolthoff method. A validated questionnaire was used to estimate how much mothers knew and how they used salt in their homes. We used χ² tests, multinomial logistic regression, and SEM to look at associations and pathways.

Results

Among households, 42 % continued to use raw or non-iodized salt, while only 58 % reported using iodized salt. Of children, 45.8 % had optimal UIC (100–299 μg/L), whereas 14.5 % and 25.3 % exhibited severe and mild iodine deficiencies, respectively. The AOR for iodized versus non-iodized salt = 14.38; 95 % CI: 6.91–29.94; p < 0.001) indicated a strong correlation with adequate UIC, along with urban residence, higher maternal education, and use of branded iodized salt. The SEM showed that maternal knowledge was a significant predictor of children's UIC (standardized β = 2.07; p = 0.004), whereas socioeconomic factors had less pronounced, indirect effects.

Conclusions

Iodine deficiency remains common among school-aged children in Noakhali, and it is more closely linked to what their mothers know and how they use salt at home than to their income. To reduce iodine deficiency, it is important to improve community education and ensure that people can access properly iodized salt, especially in rural areas.

尽管孟加拉国已经普及了食盐碘化（USI）几十年，但碘缺乏症仍然是一个持续存在的公共卫生问题，主要影响到农村和社会经济弱势社区的儿童。方法采用Sandell-Kolthoff法对诺阿哈里4个区400名6-12岁儿童进行了UIC横断面调查。使用一份有效的问卷来估计母亲知道多少盐以及她们如何在家中使用盐。我们使用χ2检验、多项逻辑回归和扫描电镜来观察关联和途径。结果在家庭中，42% %继续使用生盐或非碘盐，而只有58% %报告使用碘盐。在儿童中，45.8% %具有最佳UIC(100-299 μg/L)，而14. %和25.3 %分别表现为严重和轻度碘缺乏。加碘盐与非加碘盐的AOR = 14.38；95 % ci: 6.91-29.94；p <； 0.001)表明与足够的UIC，以及城市居住，较高的母亲教育和使用品牌碘盐有很强的相关性。SEM显示，母亲知识是儿童UIC的显著预测因子（标准化β = 2.07;p = 0.004），而社会经济因素的间接影响不太明显。结论：碘缺乏症在Noakhali的学龄儿童中仍然很普遍，这与他们的母亲所知道的知识以及他们在家里如何使用盐的关系更密切，而不是与他们的收入有关。为了减少碘缺乏症，重要的是改善社区教育，确保人们能够获得适当的碘盐，特别是在农村地区。

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引用次数: 0

Serum 25(OH)D levels are causally linked to height in European population: A mendelian randomization study 欧洲人群血清25(OH)D水平与身高有因果关系：一项孟德尔随机研究

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-11-27 DOI: 10.1016/j.hnm.2025.200357

Caiyan An , Liuyi Yang , Yanfang Wang , Junjing Zhang , Kejin Zhang

Purpose

To explore the causal relationship between serum vitamin D status and height, given that adequate vitamin D is essential for individuals to achieve their genetic height potential.

Methods

A Mendelian randomization (MR) study was conducted. Instrumental variables (IVs) were derived from genome-wide association studies (GWASs) summary statistics to estimate levels of vitamin D, 25-hydroxyvitamin D (25(OH)D), and vitamin D binding protein. Inverse variance weighted (IVW) method and MR-Radial analyses were used to assess the causal association between vitamin D levels and height in mixed populations, as well as in male and female subgroups. Sensitivity analyses were performed to verify the robustness of the findings.

Results

Under the IVW random-effects model, higher 25(OH)D levels were significantly associated with increased height all groups: mixed population (beta = 0.079, 95% CI 0.028 to 0.130, p = 0.002), females (beta = 0.078, 95% CI 0.016 to 0.140, p = 0.013), and males (beta = 0.072, 95% CI 0.019 to 0.128, p = 0.008). Additional analyses accounting for potential biases from outliers, pleiotropy, and confounding variables yielded consistent results.

Conclusions

These findings indicated a genetic association between higher serum 25(OH)D levels and increased height, supporting the role of vitamin D in height determination among European populations.

目的探讨血清维生素D水平与身高之间的因果关系，因为足够的维生素D对个体实现遗传身高潜力至关重要。方法采用孟德尔随机化（MR）研究。工具变量（IVs）来自全基因组关联研究（GWASs）汇总统计数据，用于估计维生素D、25-羟基维生素D （25(OH)D）和维生素D结合蛋白的水平。使用逆方差加权（IVW）方法和MR-Radial分析来评估混合人群以及男性和女性亚组中维生素D水平与身高之间的因果关系。进行敏感性分析以验证研究结果的稳健性。ResultsUnder IVW随机影响模型,高25 (OH) D水平显著增加高度所有组:混合人口(β = 0.079,95%可信区间0.028到0.130,p = 0.002),雌性(β = 0.078,95%可信区间0.016到0.140,p = 0.013),男性(β = 0.072,95%可信区间0.019到0.128,p = 0.008)。额外的分析考虑了异常值、多效性和混杂变量的潜在偏差，得出了一致的结果。结论：这些发现表明较高的血清25(OH)D水平与身高增加之间存在遗传关联，支持维生素D在欧洲人群身高测定中的作用。

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引用次数: 0

The effects of a high-fiber diet on biomarkers used to assess intestinal inflammation and permeability in healthy individuals 高纤维饮食对用于评估健康个体肠道炎症和通透性的生物标志物的影响

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-11-25 DOI: 10.1016/j.hnm.2025.200358

Fatma Hümeyra Yerlikaya , Zehra Doğruer , Berivan Unat , Betül Çalış , Duygu İlke Yildirim

Objectives

The present study was conducted with the objective of testing the hypothesis that a dietary intervention promoting a diet in which at least 30 g of total dietary fibre intake per day is obtained from foods affects markers related to intestinal integrity and inflammation in healthy individuals.

Metods

A total of 20 subjects participated in the study. Participants were instructed to incorporate 30 gof fibre from dietary sources into their daily consumption for a period of one month. Serum concentrations of human lipopolysaccharides Binding Protein, calprotectin, zonulin and lithocholic acid were measured using the enzyme-linked immunosorbent assay (ELISA) method before and after the dietary intervention. Serum cholesterol and anti-TPO (anti-thyroid peroxidase) levels were measured quantitatively using standard methods.

Results

A significant decrease in the BMI (p = 0.018) and weight (p = 0.015) values of the participants was observed following the implementation of a dietary intervention. The serum levels of lipopolysaccharide-binding protein (p = 0.014), calprotectin (p = 0.014), zonulin (p = 0.016), cholesterol (p = 0.036), and AntiTPO (p = 0.023) were found to be statistically significantly lower in the study participants.

Conclusions

The present study demonstrates that the consumption of 30 g of dietary fibre per day for a period of one month results in a reduction of levels of markers associated with gut integrity and inflammation in healthy individuals. A diet with a high fibre content may be a promising therapeutic target for the regulation of gut inflammation and permeability.

本研究的目的是验证一种假设，即促进每天从食物中摄入至少30 g膳食纤维的饮食干预会影响健康个体的肠道完整性和炎症相关标志物。方法共20名受试者参与本研究。参与者被要求在一个月的时间里从饮食中摄取30 纤维。采用酶联免疫吸附法（ELISA）测定饮食干预前后血清中人脂多糖结合蛋白、钙保护蛋白、糖珠蛋白和石胆酸的浓度。采用标准方法定量测定血清胆固醇和抗甲状腺过氧化物酶（tpo）水平。结果实施饮食干预后，参与者的BMI （p = 0.018）和体重（p = 0.015）值均有显著下降。lipopolysaccharide-binding的血清蛋白(p = 0.014),calprotectin (p = 0.014),zonulin (p = 0.016)、胆固醇(p = 0.036)和AntiTPO (p = 0.023)被发现统计上显著降低研究的参与者。目前的研究表明，在健康个体中，每天摄入30 g膳食纤维，持续一个月，可降低与肠道完整性和炎症相关的标志物水平。高纤维含量的饮食可能是调节肠道炎症和通透性的有希望的治疗靶点。

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引用次数: 0

Influence of dietary interventions and nutrients on oestrogen dominance in males: A systematic review 膳食干预和营养对男性雌激素优势的影响：一项系统综述

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-11-08 DOI: 10.1016/j.hnm.2025.200354

D Michael Elliott , Jessica Bayes , Janet Schloss

Background

As males age, declining testosterone levels may result in a relative hormonal imbalance, often described as “estrogen dominance.” Up to 30 % of males aged ≥60 years experience low testosterone levels which can alter the testosterone-to-oestrogen ratio and contribute to associated symptoms. This systematic review examines the relationship between diet, nutrients, and oestrogen dominance in males exploring their potential as accessible interventions for chronic conditions linked to oestrogen imbalance in both males and females. The review focuses on identifying specific foods and nutrients influencing oestrogen dominance in males, while recognising that findings may have broader implications for females.

Methods

Data sources included PubMed, AMED, SCOPUS, and CINAHL from 2000 to 2024. Twelve studies met the inclusion criteria. All studies were independently screened by two reviewers with discrepancies resolved by a third. Primary outcomes included: (1) evidence of reduced oestrogen levels, (2) evidence of increased oestrogen levels, (3) no significant change in oestrogen levels. Secondary outcomes included sex hormone binding-globulin, aromatase activity and progesterone levels. The protocol was prospectively registered in PROSPERO (registration number: CRD42024582893).

Results

A total of 766 citations were identified from which 12 relevant studies were analysed. Seven studies demonstrated reduced oestrogen levels following consumption of coffee, ergocalciferol, D-chiro-inositol, soy products, and tree nuts. Two studies reported increased oestrogen levels with higher macronutrient intake, particularly albumin and after supplementation with 107 mg of isoflavones. Three studies showed no notable effect.

Conclusion

This review highlights that dietary components and nutrients can influence oestrogen dominance in males experiencing age-related declines in testosterone levels and increased conversion of testosterone to oestrogen, with potential implications for cardiovascular, prostate and metabolic health.

随着男性年龄的增长，睾酮水平的下降可能导致相对的激素失衡，通常被描述为“雌激素主导”。高达30% %年龄≥60岁的男性经历低睾丸激素水平，这可以改变睾丸激素对雌激素的比例并导致相关症状。这篇系统综述探讨了饮食、营养和男性雌激素优势之间的关系，探讨了它们作为男性和女性雌激素失衡相关慢性疾病的干预措施的潜力。这篇综述的重点是确定影响男性雌激素优势的特定食物和营养物质，同时认识到这些发现可能对女性有更广泛的影响。方法2000 - 2024年的数据来源包括PubMed、AMED、SCOPUS和CINAHL。12项研究符合纳入标准。所有研究均由两位评论者独立筛选，差异由第三位评论者解决。主要结局包括：(1)雌激素水平降低的证据，(2)雌激素水平升高的证据，(3)雌激素水平无显著变化。次要结局包括性激素结合球蛋白、芳香化酶活性和黄体酮水平。该方案在PROSPERO中前瞻性注册（注册号：CRD42024582893）。结果共收录文献766篇，分析相关文献12篇。七项研究表明，饮用咖啡、麦角钙化醇、d -氨基肌醇、豆制品和坚果后，雌激素水平会降低。两项研究报告，摄入大量营养素，特别是白蛋白和补充107 mg异黄酮后，雌激素水平升高。三项研究显示无显著效果。结论饮食成分和营养成分可影响男性雌激素优势，导致睾酮水平随年龄下降，睾酮向雌激素转化增加，对心血管、前列腺和代谢健康具有潜在影响。

{"title":"Influence of dietary interventions and nutrients on oestrogen dominance in males: A systematic review","authors":"D Michael Elliott , Jessica Bayes , Janet Schloss","doi":"10.1016/j.hnm.2025.200354","DOIUrl":"10.1016/j.hnm.2025.200354","url":null,"abstract":"<div><h3>Background</h3><div>As males age, declining testosterone levels may result in a relative hormonal imbalance, often described as “estrogen dominance.” Up to 30 % of males aged ≥60 years experience low testosterone levels which can alter the testosterone-to-oestrogen ratio and contribute to associated symptoms. This systematic review examines the relationship between diet, nutrients, and oestrogen dominance in males exploring their potential as accessible interventions for chronic conditions linked to oestrogen imbalance in both males and females. The review focuses on identifying specific foods and nutrients influencing oestrogen dominance in males, while recognising that findings may have broader implications for females.</div></div><div><h3>Methods</h3><div>Data sources included PubMed, AMED, SCOPUS, and CINAHL from 2000 to 2024. Twelve studies met the inclusion criteria. All studies were independently screened by two reviewers with discrepancies resolved by a third. Primary outcomes included: (1) evidence of reduced oestrogen levels, (2) evidence of increased oestrogen levels, (3) no significant change in oestrogen levels. Secondary outcomes included sex hormone binding-globulin, aromatase activity and progesterone levels. The protocol was prospectively registered in PROSPERO (registration number: CRD42024582893).</div></div><div><h3>Results</h3><div>A total of 766 citations were identified from which 12 relevant studies were analysed. Seven studies demonstrated reduced oestrogen levels following consumption of coffee, ergocalciferol, D-chiro-inositol, soy products, and tree nuts. Two studies reported increased oestrogen levels with higher macronutrient intake, particularly albumin and after supplementation with 107 mg of isoflavones. Three studies showed no notable effect.</div></div><div><h3>Conclusion</h3><div>This review highlights that dietary components and nutrients can influence oestrogen dominance in males experiencing age-related declines in testosterone levels and increased conversion of testosterone to oestrogen, with potential implications for cardiovascular, prostate and metabolic health.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"43 ","pages":"Article 200354"},"PeriodicalIF":1.8,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationship between folate and thrombotic external hemorrhoids: A two-sample Mendelian Randomization analysis 叶酸与血栓性外痔的因果关系：一项双样本孟德尔随机分析

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-10-31 DOI: 10.1016/j.hnm.2025.200353

Qi Yang, TianYang Chen, TianQi Gao, YanTong Liu, GuoFeng Li

Background

Thrombotic external hemorrhoids (TEH) may be influenced by micronutrient levels. This study investigates the causal relationship between TEH and 15 micronutrients, including folate, calcium, and vitamins A, C, D, E, B6, and B12.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted using single nucleotide polymorphisms (SNPs) associated with micronutrient levels (p < 5 × 10⁻⁶) from genome-wide association studies (GWAS) in European populations (n = 64,979 for folate). TEH outcome data were sourced from the FinnGen Biobank (n = 9749). The inverse variance weighted (IVW) method was used, with SNPs selected to ensure strong instrumental variables (F > 10). Sensitivity and pleiotropy analyses were performed.

Results

IVW analysis revealed a causal association between folate and TEH (p-value = 0.004, OR = 1.555 [95 % CI 1.156–2.092] per standard deviation increase in folate levels). Sensitivity analyses confirmed the robustness of this finding.

Conclusion

Folate is a risk factor for TEH, potentially via inflammatory pathways, providing evidence to guide clinical research and TEH management strategies.

背景血栓性外痔（TEH）可能受微量营养素水平的影响。本研究调查了TEH与15种微量营养素之间的因果关系，包括叶酸、钙、维生素A、C、D、E、B6和B12。方法利用欧洲人群全基因组关联研究（GWAS）中与微量元素水平相关的单核苷酸多态性（snp）（p <； 5 × 10−6）进行双样本孟德尔随机化（MR）分析（叶酸n = 64,979）。TEH结果数据来源于FinnGen生物银行（n = 9749）。采用逆方差加权（IVW）方法，选择snp以确保强大的工具变量（F >； 10）。进行敏感性和多效性分析。结果vw分析显示叶酸与TEH之间存在因果关系（p值 = 0.004,OR = 1.555[95 % CI 1.156-2.092] /叶酸水平增加的标准差）。敏感性分析证实了这一发现的稳健性。结论叶酸是TEH的危险因素，可能通过炎症途径发生，为指导临床研究和TEH管理策略提供依据。

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引用次数: 0

Associations of SLC30A8 polymorphisms with metabolic and dietary parameters in a Brazilian obesity cohort 巴西肥胖人群中SLC30A8多态性与代谢和饮食参数的关系

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-10-31 DOI: 10.1016/j.hnm.2025.200351

Flavia de Campos Ferreira , Marcela Augusta de Souza Pinhel , Lígia Moriguchi Watanabe , Luisa Maria Diani , Wilson Salgado Junior , Rafael Ferreira Fernandes , Maysa de Araújo Ferreira-Julio , Natália Yumi Noronha , Carla Barbosa Nonino

Background

Obesity is a complex condition influenced by genetic and environmental factors. Beyond known appetite/satiety single nucleotide polymorphisms (SNPs), comprehensive genomic screening can reveal novel and clinically relevant associations.

Objective

To investigate genetic associations of SNPs with anthropometric, biochemical, and dietary variables in a Brazilian obesity cohort.

Methods

This cross-sectional study included 106 Brazilian individuals with obesity, categorized by severity (class I/II, n = 23; class III, n = 83). Anthropometric, body composition, biochemical, and dietary data were collected. Genotyping (Illumina®) analyzed approximately 640,000 SNPs. Associations were assessed via dominant/recessive genetic models, and a polygenic risk score (PRS) was constructed.

Results

No significant associations were found with classical appetite/satiety SNPs. However, comprehensive genomic screening identified two prevalent SLC30A8 SNPs (rs13266634, rs11558471). These SNPs were significantly associated with higher HDL cholesterol (p < 0.05). Specific homozygous genotypes (CC for rs13266634, AA for rs11558471) linked to increased protein intake solely in class III obesity. The constructed PRS did not demonstrate predictive value for overall obesity risk (AUC = 0.520; p > 0.05).

Conclusion

Our study unveils novel links between SLC30A8 variants and key metabolic (HDL-c) and dietary (protein intake) markers in obesity, contrasting with classical appetite-related SNPs. These findings suggest a broader, significant role for SLC30A8 in complex obesity phenotyping. The polygenic risk score was not predictive in this cohort.

肥胖是一种受遗传和环境因素影响的复杂疾病。除了已知的食欲/饱腹感单核苷酸多态性（snp），全面的基因组筛选可以揭示新的和临床相关的关联。目的研究巴西肥胖人群中snp与人体测量、生化和饮食变量的遗传关系。方法本横断面研究纳入106名巴西肥胖患者，按严重程度分类（I/II级，n = 23；III级，n = 83）。收集了人体测量、身体成分、生化和饮食数据。基因分型（Illumina®）分析了大约64万个snp。通过显性/隐性遗传模型评估相关性，并构建多基因风险评分（PRS）。结果与经典的食欲/饱腹感snp无显著关联。然而，综合基因组筛选鉴定出两个普遍存在的SLC30A8 snp （rs13266634, rs11558471）。这些snp与较高的HDL胆固醇显著相关（p <； 0.05）。特异性纯合子基因型（rs13266634为CC， rs11558471为AA）仅在III类肥胖中与蛋白质摄入量增加有关。构建的PRS对总体肥胖风险没有预测价值（AUC = 0.520;p >； 0.05）。我们的研究揭示了SLC30A8变异与肥胖关键代谢（HDL-c）和饮食（蛋白质摄入）标志物之间的新联系，与经典的食欲相关snp相比。这些发现表明SLC30A8在复杂肥胖表型中具有更广泛、更重要的作用。多基因风险评分在该队列中不具有预测性。

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引用次数: 0

Dietary influences on the gut-brain pathways: Mechanisms and therapeutic potential 饮食对肠-脑通路的影响：机制和治疗潜力

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-10-30 DOI: 10.1016/j.hnm.2025.200349

Aswani Ajay , Supriya Singh Gaur , Jyoti Singh , Rafeeya Shams , Kshirod Kumar Dash , Ayaz Shaikh Mukarram , Bela Kovács

There is emerging evidence that the gut-brain axis can be significantly influenced through a gut friendly diet. Indeed, nutritional neuroscience holds a significant role in managing the gut brain axis and mental health disorders as numerous pathways, chiefly, neurological, humoral and immune pathways are involved in the bidirectional communication of gut and brain. Moreover, these pathways are interlinked with the gut microbiota, performing a synergistic effect on gut-brain axis. Consequently, nutrients and gut metabolites have become crucial for managing the gut-brain communication and thereby handling various mental health disorders. Furthermore, the incorporation of dietary interventions through special diets can efficiently contribute to the maintenance of gut-brain health. Apart from this, advanced nutritional therapies, i.e., nutritional psychiatry, microbial biotherapies have been shown promising effects on altered gut brain signalling and health. Nonetheless, the role of nutritional diet in managing the gut brain axis is yet to be discussed in detail. Additionally, there is a growing need to investigate the impact of nutrients on healthy gut-brain communication within the field of nutritional psychiatry. On account of these gaps and findings, this review highlights the importance of diet and nutrition on a healthy gut-brain axis through the mechanism of action of different nutritional compounds, impact of special diets and novel nutritional and psychobiotic influenced strategies.

越来越多的证据表明，肠道友好型饮食可以显著影响肠脑轴。事实上，营养神经科学在管理肠道脑轴和精神健康障碍方面发挥着重要作用，因为许多途径，主要是神经、体液和免疫途径，参与了肠道和大脑的双向交流。此外，这些途径与肠道微生物群相互关联，在肠-脑轴上发挥协同作用。因此，营养物质和肠道代谢物对于管理肠-脑沟通，从而处理各种精神健康障碍变得至关重要。此外，通过特殊饮食结合饮食干预可以有效地促进维持肠道-大脑健康。除此之外，先进的营养疗法，即营养精神病学，微生物生物疗法已经显示出对改变肠道大脑信号和健康的有希望的影响。尽管如此，营养饮食在肠脑轴管理中的作用还有待详细讨论。此外，在营养精神病学领域，越来越需要调查营养素对健康的肠-脑交流的影响。鉴于这些差距和发现，本文通过不同营养化合物的作用机制、特殊饮食的影响以及新的营养和心理影响策略，强调饮食和营养对健康肠-脑轴的重要性。

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引用次数: 0

Investigation and analysis of vitamin D status in a coastal city population of southeast China 东南沿海城市人群维生素D状况调查分析

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-10-30 DOI: 10.1016/j.hnm.2025.200352

Yanwen Chen , Shengwu Yu , Wenjie Ying , Huan Chai , Yining Zhang

Objectives

To characterize vitamin D levels and related influencing factors in the population of coastal cities in southeast China.

Methods

We retrospectively analyzed the results of serum 25-hydroxyvitamin D3 [25(OH) D3] during outpatient visits and physical examinations at Ningbo Hangzhou Bay Hospital from 2019 to 2024, and assessed the relationship between vitamin D levels and gender, age, and hematological indexes in this region's population.

Results

In the physical examination population, the proportions of vitamin D levels classified as normal, insufficient, and deficient were 2.78 %, 16.59 %, and 80.64 %, respectively; indicating that the vitamin D deficiency rate is higher than that in the outpatient population. Moreover, the proportion of men with vitamin D deficiency was lower than that of women; the difference was statistically significant (p < 0.05). The proportion of vitamin D deficiency decreased with age in both sexes, with levels showing statistically significant differences among age groups (p < 0.05). Additionally, AST, PA, CREA, UREA and EGFR-EPI Cr were identified as independent factors for the clinical guidance of vitamin D deficiency medication (p < 0.05). ALT, CREA, UREA, Ca, Na, Hb, HCT, MCHC were correlated with the proportion of vitamin D deficiency in individuals under 60 (p < 0.05); only ALP was correlated with vitamin D levels in people over 60 years of age (p < 0.05).

Conclusion

Vitamin D deficiency was more prevalent in the physical examination population. Gender and age can influence vitamin D levels. There was a correlation between various hematologic markers and vitamin D levels in the physical examination population.

目的了解东南沿海城市人群维生素D水平及其影响因素。方法回顾性分析宁波市杭州湾医院2019 - 2024年门诊和体检患者血清25(OH) D3 [25(OH) D3]水平，评估该地区人群维生素D水平与性别、年龄、血清学指标的关系。结果体检人群中维生素D水平正常、不足和缺乏的比例分别为2.78 %、16.59 %和80.64 %；表明维生素D缺乏率高于门诊人群。此外，男性缺乏维生素D的比例低于女性；差异有统计学意义（p <； 0.05）。男女维生素D缺乏症比例随年龄增长而下降，各年龄组间差异有统计学意义（p <； 0.05）。AST、PA、CREA、尿素、EGFR-EPI Cr是临床指导维生素D缺乏症用药的独立因素（p <； 0.05）。ALT、CREA、尿素、Ca、Na、Hb、HCT、MCHC与60岁以下人群维生素D缺乏症比例相关（p <； 0.05）；60岁以上人群中只有ALP与维生素D水平相关（p <； 0.05）。结论维生素D缺乏症在体检人群中更为普遍。性别和年龄会影响维生素D水平。在体检人群中，各种血液学指标与维生素D水平之间存在相关性。

{"title":"Investigation and analysis of vitamin D status in a coastal city population of southeast China","authors":"Yanwen Chen , Shengwu Yu , Wenjie Ying , Huan Chai , Yining Zhang","doi":"10.1016/j.hnm.2025.200352","DOIUrl":"10.1016/j.hnm.2025.200352","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize vitamin D levels and related influencing factors in the population of coastal cities in southeast China.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed the results of serum 25-hydroxyvitamin D3 [25(OH) D3] during outpatient visits and physical examinations at Ningbo Hangzhou Bay Hospital from 2019 to 2024, and assessed the relationship between vitamin D levels and gender, age, and hematological indexes in this region's population.</div></div><div><h3>Results</h3><div>In the physical examination population, the proportions of vitamin D levels classified as normal, insufficient, and deficient were 2.78 %, 16.59 %, and 80.64 %, respectively; indicating that the vitamin D deficiency rate is higher than that in the outpatient population. Moreover, the proportion of men with vitamin D deficiency was lower than that of women; the difference was statistically significant (<em>p < 0.05</em>). The proportion of vitamin D deficiency decreased with age in both sexes, with levels showing statistically significant differences among age groups (<em>p < 0.05</em>). Additionally, AST, PA, CREA, UREA and EGFR-EPI Cr were identified as independent factors for the clinical guidance of vitamin D deficiency medication (<em>p < 0.05</em>). ALT, CREA, UREA, Ca, Na, Hb, HCT, MCHC were correlated with the proportion of vitamin D deficiency in individuals under 60 (<em>p < 0.05</em>); only ALP was correlated with vitamin D levels in people over 60 years of age (<em>p < 0.05</em>).</div></div><div><h3>Conclusion</h3><div>Vitamin D deficiency was more prevalent in the physical examination population. Gender and age can influence vitamin D levels. There was a correlation between various hematologic markers and vitamin D levels in the physical examination population.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"43 ","pages":"Article 200352"},"PeriodicalIF":1.8,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of prolonged confined space operations on human gut microbiota and serum metabolome 长时间密闭空间手术对人体肠道菌群和血清代谢组的影响

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism

Pub Date : 2025-10-21 DOI: 10.1016/j.hnm.2025.200347

Fuqiang Sun, Geli Qin, Hao Zeng, Miaosheng Guan, Hui Liu, Hongjie Qiu, Tiantian Wei, Hongfang Hu

Objective

Psychophysiological stress caused by long-term closed environments can disturb the homeostasis of the intestinal flora, which can aggravate bodily stress through metabolic dysfunction, forming a vicious circle. The purpose of this study was to analyze the mechanisms of the intestinal flora and serum metabolism of individuals working in closed environments, reveal the characteristics of the flora and metabolomes of such workers, and provide the basis for health protection.

Methods

Fecal and serum samples of nine healthy volunteers were collected before entering the cabin, and on days 14 and 28, the intestinal microflora was analyzed via 16 S rRNA sequencing. Serum metabolomics analysis was performed via LC-MS. Serum inflammatory factors were analyzed using the targeted proteome Olink technique.

Results

A total of 6373 OTUs were identified. At the gate level, 5/9 of the subjects exhibited significantly increased levels of Proteobacteria on day 14, and 6/9 of the subjects exhibited increased levels of Firmicutes on Day 28. Bacteroides levels continued to decrease. Linear discriminant analysis effect size showed a decrease in Prevotellamassilia timonensis and Alloprevotella and an increase in Clostridiales spp. By day 28. LC-MS revealed that 93 metabolites were upregulated and 178 metabolites were downregulated compared with the baseline. KEGG enrichment analysis showed that amino acid biosynthesis was significantly activated on day 14 (P < 0.05), while steroid hormone and fatty acid biosynthesis dominated on day 28. Olink analysis revealed significantly increased expression of IL-2 and CCL23 on day 28 (P < 0.05).

Conclusion

The closed environment can induce structural adjustment of the microbial community (enrichment of Firmicutes and reduction of Bacteroides), which can lead to dynamic reprogramming of serum metabolites and gradual activation of inflammation. These findings suggest the temporal adaptability of microbial metabolic functions and host inflammatory response.

目的长期封闭环境引起的心理生理应激会扰乱肠道菌群的内稳态，进而通过代谢功能障碍加重机体应激，形成恶性循环。本研究旨在分析封闭环境下劳动者肠道菌群和血清代谢的机制，揭示封闭环境下劳动者肠道菌群和代谢组的特征，为健康防护提供依据。方法9名健康志愿者在入舱前采集粪便和血清样本，于第14天和第28天采用16s rRNA测序法分析肠道菌群。采用LC-MS进行血清代谢组学分析。使用靶向蛋白质组Olink技术分析血清炎症因子。结果共鉴定出6373个otu。在门水平，5/9的受试者在第14天表现出变形菌门水平显著升高，6/9的受试者在第28天表现出厚壁菌门水平显著升高。拟杆菌水平继续下降。线性判别分析效应大小显示，28 d时，timmonamassilia prevotella和Alloprevotella减少，Clostridiales spp.增加。LC-MS显示，与基线相比，93种代谢物上调，178种代谢物下调。KEGG富集分析表明，氨基酸生物合成在第14天显著激活（P < 0.05），而类固醇激素和脂肪酸生物合成在第28天占主导地位。链接分析显示，第28天IL-2和CCL23的表达显著升高（P < 0.05）。结论封闭环境可诱导微生物群落结构调整（厚壁菌门富集、拟杆菌门减少），导致血清代谢物的动态重编程和炎症的逐渐激活。这些发现提示微生物代谢功能和宿主炎症反应的时间适应性。

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引用次数: 0