Application of gas molecules in cancer therapy

Biomedical Technology Pub Date : 2023-12-08 DOI:10.1016/j.bmt.2023.11.001

Danna Liang , Qingfei Zhang , Xiang Chen , Jianhua Lu , Xian Shen , Weijian Sun

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Abstract

Gas therapy is currently popular in cancer treatment because of its controllability, effectiveness, and biosafety, as well as the fast development of carriers for gas delivery. Here, we introduce the various gas molecules with exact anticancer effects, including nitric oxide (NO), carbon monoxide (CO), oxygen (O₂), hydrogen (H₂), etc., and their anticancer mechanisms. Besides, recent advances in stimuli-responsive delivery systems for gas therapy are summarized. In terms of the various stimulation methods, the design of delivery systems for gases is introduced. In addition, the strategies of gas therapy combined with other therapeutic modalities, including chemotherapy, radiotherapy (RT), photodynamic therapy (PDT), photothermal therapy (PTT), etc., are described. Finally, the current challenges and prospects of delivery platforms for gases, and the future development and clinical translational value of gas therapy are also discussed.

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气体分子在癌症治疗中的应用

气体疗法因其可控性、有效性和生物安全性，以及气体输送载体的快速发展，目前在癌症治疗中备受青睐。在此，我们将介绍具有确切抗癌作用的各种气体分子，包括一氧化氮（NO）、一氧化碳（CO）、氧气（O2）、氢气（H2）等，以及它们的抗癌机理。此外，还总结了用于气体疗法的刺激响应输送系统的最新进展。从各种刺激方法的角度介绍了气体输送系统的设计。此外，还介绍了气体疗法与其他治疗方式相结合的策略，包括化疗、放疗（RT）、光动力疗法（PDT）、光热疗法（PTT）等。最后，还讨论了气体输送平台目前面临的挑战和前景，以及气体疗法的未来发展和临床转化价值。

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来源期刊

Biomedical Technology

CiteScore

4.10

自引率

0.00%

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