Preventive effect of aspirin on peripherally inserted central catheter-related vein thrombosis in patients with malignant tumors

IF 1.1 Q3 NURSING Journal of Vascular Nursing Pub Date : 2023-12-01 DOI:10.1016/j.jvn.2023.06.003

Caiyan Yu , Shaohua Sun , Xiuqing Shi, Li Wang, Qian Zhang, Lin Zhang , Dehua Song

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Abstract

The majority of patients receiving chemotherapy undergo PICC catheterization. However, PICCs are significantly associated with catheter related complications, including deep vein thrombosis, blood infection, fibrin sheath, catheter prolapse, catheter displacement and blockage. Of all the risks, PICC-related VT was the most prevailing clinic symptom and resulted in a high risk of death.

Aim

The study aimed to investigate the preventive efficacy and safety of aspirin for patients with malignant tumors receiving venous thrombosis (VT) related with peripherally inserted central catheters (PICC) treatment.

Patients and Methods

A randomized controlled trial was conducted. Participants with malignant tumors receiving chemotherapy who accepted PICC insertion operation were randomly allocated to the aspirin treatment group (n = 235) or the control group (n = 246). The patients in the aspirin group were administrated aspirin (100mg) for 30 days, whereas the patients in control group were administrated a placebo drug. The incidence of PICC-related VT in both groups and the aspirin related adverse effects were evaluated.

Results

The incidence of PICC-related VT was 0.4% in the aspirin group, compared with 3.3% in the control group (P = 0.038). In addition, aspirin related bleeding was not observed.

Conclusion

PICC-related VT could be effectively prevented by aspirin in patients with malignant tumors.

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阿司匹林对恶性肿瘤患者外周置入中央导管相关静脉血栓形成的预防作用

摘要大多数接受化疗的患者都要进行 PICC 导管置管。然而，PICC 与导管相关并发症密切相关，包括深静脉血栓、血液感染、纤维蛋白鞘、导管脱垂、导管移位和堵塞。该研究旨在探讨阿司匹林对接受外周置入中心导管（PICC）治疗的静脉血栓（VT）相关恶性肿瘤患者的预防效果和安全性。接受 PICC 插管手术的恶性肿瘤化疗患者被随机分配到阿司匹林治疗组（235 人）或对照组（246 人）。阿司匹林治疗组患者服用阿司匹林（100 毫克）30 天，而对照组患者服用安慰剂。结果阿司匹林组与 PICC 相关的 VT 发生率为 0.4%，而对照组为 3.3%（P = 0.038）。结论阿司匹林可有效预防恶性肿瘤患者的 PICC 相关 VT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Nursing NURSING-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Journal of Vascular Nursing provides clinical information regarding aortic and peripheral aneurysms, upper and lower extremity arterial disease, acute and chronic venous disease, and more. Original, peer-reviewed articles present descriptions, etiologies, diagnostic procedures, medical and surgical treatment and nursing implications of vascular system disorders.