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Review of article: Cucato G, Longano PPL, Perren D, Ritti-Dias RM, Saxton JM. Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral arterial disease. Cochrane Database of Systematic Reviews 2024, Issue 5. Art. No.: CD014736 文献综述:Cucato G, Longano PPL, Perren D, Ritti-Dias RM, Saxton JM。有症状的外周动脉疾病患者血管干预成功后额外运动治疗的效果。Cochrane数据库系统评价2024,第5期。艺术。否。: CD014736
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.11.002
Rebecca JL Brown PhD, MEd, RN
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引用次数: 0
Impact of disease severity on physical function in patients with chronic venous insufficiency: A cross-sectional study 疾病严重程度对慢性静脉功能不全患者身体功能的影响:一项横断面研究
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.08.001
Wagner Jorge Ribeiro Domingues , Emely Kércia Santiago de Souza Brandão , Lenon Corrêa de Souza , Emmina Lima da Cruz de Souza , Paulo Lucas da Silva e Silva , Stephanie Vitória Alves dos Santos , Priscilla Ribeiro dos Santos Campelo , Neivaldo José Nazaré dos Santos , Caroline Ferraz Simões

Background

Chronic venous insufficiency (CVI) affects physical function; however, the impact of disease severity on gait, balance, and handgrip strength in patients with CVI remains unclear.

Objective

To evaluate the impact of the clinical severity of CVI on physical function parameters in patients in less severe stages (CEAP C3–C4) compared to those in more advanced stages of the disease (CEAP C5–C6).

Methods

This cross-sectional study included 96 patients of both sexes with CVI with Etiology-Anatomy-Pathology (CEAP) C3 to C6. Physical function was measured using the six-minute walk test (6MWT), Short Physical Performance Battery (SPPB), Gait speed (usal and fast) and handgrip strength. The Mann-Whitney U test was applied to compare physical function indicators according to the disease severity of CVI (CEAP C3-C4 and CEAP C5-C6).

Results

Patients with CVI CEAP C3-C4 walked 68 meters longer compared to individuals with CVI CEAP C5-C6 (451 m vs 383 m; p = 0.001 respectively) and had a higher total score on the SPPB (11 vs 10 points; p = 0.029). For the other tests there were no statistical differences (P > 0.05).

Conclusion

Therefore, the clinical severity of CVI appears to influence physical function, with patients in less severe stages (CEAP C3-C4) of the disease demonstrating better walking distances and SPPB scores compared with those classified in more advanced stages of the disease (CEAP C5-C6).
背景:慢性静脉功能不全(CVI)影响身体功能;然而,疾病严重程度对CVI患者的步态、平衡和握力的影响尚不清楚。目的评价CVI临床严重程度对较轻期(CEAP C3-C4)患者与较晚期(CEAP C5-C6)患者身体功能参数的影响。方法本横断面研究包括96例男女CVI患者,病因-解剖-病理(CEAP) C3至C6。采用6分钟步行测试(6MWT)、短时物理性能电池(SPPB)、步态速度(慢速和快速)和握力测量身体功能。采用Mann-Whitney U检验比较不同CVI疾病严重程度的身体功能指标(CEAP C3-C4和CEAP C5-C6)。结果CVI CEAP C3-C4患者比CVI CEAP C5-C6患者步行时间长68米(451米比383米,p = 0.001), SPPB总分更高(11分比10分,p = 0.029)。其他试验无统计学差异(P > 0.05)。因此,CVI的临床严重程度似乎会影响身体功能,较轻阶段(CEAP C3-C4)的患者与较晚期阶段(CEAP C5-C6)的患者相比,步行距离和SPPB评分更好。
{"title":"Impact of disease severity on physical function in patients with chronic venous insufficiency: A cross-sectional study","authors":"Wagner Jorge Ribeiro Domingues ,&nbsp;Emely Kércia Santiago de Souza Brandão ,&nbsp;Lenon Corrêa de Souza ,&nbsp;Emmina Lima da Cruz de Souza ,&nbsp;Paulo Lucas da Silva e Silva ,&nbsp;Stephanie Vitória Alves dos Santos ,&nbsp;Priscilla Ribeiro dos Santos Campelo ,&nbsp;Neivaldo José Nazaré dos Santos ,&nbsp;Caroline Ferraz Simões","doi":"10.1016/j.jvn.2025.08.001","DOIUrl":"10.1016/j.jvn.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Chronic venous insufficiency (CVI) affects physical function; however, the impact of disease severity on gait, balance, and handgrip strength in patients with CVI remains unclear.</div></div><div><h3>Objective</h3><div>To evaluate the impact of the clinical severity of CVI on physical function parameters in patients in less severe stages (CEAP C3–C4) compared to those in more advanced stages of the disease (CEAP C5–C6).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 96 patients of both sexes with CVI with Etiology-Anatomy-Pathology (CEAP) C3 to C6. Physical function was measured using the six-minute walk test (6MWT), Short Physical Performance Battery (SPPB), Gait speed (usal and fast) and handgrip strength. The Mann-Whitney U test was applied to compare physical function indicators according to the disease severity of CVI (CEAP C3-C4 and CEAP C5-C6).</div></div><div><h3>Results</h3><div>Patients with CVI CEAP C3-C4 walked 68 meters longer compared to individuals with CVI CEAP C5-C6 (451 m vs 383 m; p = 0.001 respectively) and had a higher total score on the SPPB (11 vs 10 points; p = 0.029). For the other tests there were no statistical differences (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Therefore, the clinical severity of CVI appears to influence physical function, with patients in less severe stages (CEAP C3-C4) of the disease demonstrating better walking distances and SPPB scores compared with those classified in more advanced stages of the disease (CEAP C5-C6).</div></div>","PeriodicalId":45419,"journal":{"name":"Journal of Vascular Nursing","volume":"43 4","pages":"Pages 186-191"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-efficacy and its effect on step count in patients with intermittent claudication after endovascular interventions: A six-month quantitative study 血管内干预后间歇性跛行患者的自我效能感及其对步数的影响:一项为期六个月的定量研究
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.08.006
Chedva Levin , Omar Baha , Malak Hater , Adar Klein-Druyan , Mor Saban

Background

Endovascular intervention is often associated with improvements in physical function in patients with peripheral artery disease. Self-efficacy, the belief in one’s ability to successfully carry out specific behaviors, is a well-established determinant of exercise engagement in diverse populations, including those with peripheral artery disease. However, the role of self-efficacy in maintaining basic and instrumental activities of daily living following endovascular intervention is unclear.

Aim

To investigate the relationship between self-efficacy and functioning, walking capacity, and emotional well-being in patients with peripheral artery disease before and after endovascular interventions.

Methods

Twenty-eight individuals with peripheral artery disease presenting with either intermittent claudication or critical limb-threatening ischemia—who underwent endovascular interventions participated in this study. Standardized questionnaires were used to assess self-efficacy, anxiety, and depression. Daily-steps were calculated by a smartwatch. Independence in performing daily living activities was assessed using the modified Barthel Activities of Daily-Living Index and the independence in instrumental activities of daily-living questionnaire. Data was collected before the intervention (T1), at three months (T2), and at six months post-intervention (T3); this design enabled a comprehensive analysis of changes over time.

Results

Initially, higher self-efficacy correlated with better functioning of daily activities (r = 0.437, p < 0.01) and instrumental activities (r = 0.475, p < 0.01). At six months, higher self-efficacy correlated positively with all domains, including increased step count (r = 0.555, p < 0.01). Self-efficacy had a significant negative correlation with reported anxiety (r = -0.574, p < 0.01) and depression levels (r = -0.622, p < 0.01) post-treatment. A positive association was observed between female sex and self-efficacy in those with initially high self-efficacy levels.

Conclusions

Self-efficacy influences outcomes such as functional abilities, physical activity, and mental wellness in patients with peripheral artery disease following endovascular interventions.
背景:血管干预通常与外周动脉疾病患者身体功能的改善相关。自我效能感,即对自己成功完成特定行为的能力的信念,是各种人群(包括外周动脉疾病患者)参与锻炼的一个公认的决定因素。然而,自我效能感在血管内介入治疗后维持基本和工具性日常生活活动中的作用尚不清楚。目的探讨血管内介入治疗前后外周动脉疾病患者自我效能感与功能、行走能力和情绪幸福感的关系。方法采用血管内介入治疗的28例外周动脉疾病患者,表现为间歇性跛行或严重肢体威胁性缺血。标准化问卷用于评估自我效能、焦虑和抑郁。每日步数由智能手表计算。采用改进的Barthel日常生活活动指数和日常生活问卷工具性活动的独立性来评估进行日常生活活动的独立性。在干预前(T1)、干预后3个月(T2)和干预后6个月(T3)收集数据;这种设计能够全面分析随着时间的变化。结果最初,较高的自我效能感与较好的日常活动功能(r = 0.437, p < 0.01)和工具活动(r = 0.475, p < 0.01)相关。在6个月时,较高的自我效能感与所有领域呈正相关,包括步数增加(r = 0.555, p < 0.01)。自我效能与治疗后报告的焦虑(r = -0.574, p < 0.01)和抑郁水平(r = -0.622, p < 0.01)呈显著负相关。在最初自我效能水平高的人群中,女性性别与自我效能之间存在正相关。结论自我效能感影响外周动脉疾病患者血管内介入治疗后的功能能力、身体活动和心理健康。
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引用次数: 0
Factors influencing negative emotional stages in patients with chronic limb-threatening ischemia prior to surgery 影响手术前慢性肢体缺血患者负性情绪阶段的因素
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.08.002
Nutthawadee Sinporn , Kessiri Wongkongkam , Suporn Danaidutsadeekul , Khamin Chinsakchai

Introduction

Negative emotional stages are defined as stress, anxiety, and depression. These psychological symptoms can occur among patients with peripheral arterial disease before surgery especially those who present with chronic limb-threatening ischemia (CLTI).

Objective

This study aims to examine predictive factors of negative emotional stages - age, smoking, walking ability, signs and symptoms - of patients with CLTI before surgery.

Methods

This is a descriptive study of 90 patients with CLTI before surgery who met the inclusion and exclusion criteria recruited from two tertiary hospitals, in Bangkok, Thailand. The walking impairment questionnaire, Rutherford’s categories, and Depression Anxiety Stress Scales (DASS - 21) were used for collecting data.

Results

Of 90 preoperative CLTI patients, 57.8 % were male, with an average age of 71.90 years (SD = 11.32). The participants had depression and anxiety equal to 24.4 % and stress for 7.8 %. The majority of the participants had depression, anxiety, and stress scores in mild levels, 13.3 % (x¯ = 3.30, SD = 2.69), 17.8 % (x¯= 2.36, SD = 2.14), and 4.4 % (x¯= 3.47, SD = 3.12), respectively. 32.2 % of the participants had a negative emotional stage in one symptom. The multiple linear regression analysis by the backward method found that age can predict depression symptoms with statistically significant (β = -0.282, p < .05). Walking ability can predict anxiety symptoms with statistically significant (β = -0.278, p < .05). Age and walking ability can predict stress symptoms with statistically significant (β = -0.207, p < .05, β = -0.302, p < .05).

Conclusions

This study shows that age and walking ability influence negative emotional states in patients with CLTI before surgery.
消极的情绪阶段被定义为压力、焦虑和抑郁。这些心理症状可发生在手术前患有外周动脉疾病的患者中,特别是那些存在慢性肢体威胁缺血(CLTI)的患者。目的探讨CLTI患者术前负性情绪分期的预测因素——年龄、吸烟、行走能力、体征和症状。方法:本研究是一项描述性研究,从泰国曼谷的两家三级医院招募了90名符合纳入和排除标准的术前CLTI患者。采用步行障碍问卷、卢瑟福分类、抑郁焦虑压力量表(DASS - 21)收集数据。结果90例术前CLTI患者中,男性占57.8%,平均年龄71.90岁(SD = 11.32)。24.4%的人有抑郁和焦虑,7.8%的人有压力。大多数参与者的抑郁、焦虑和压力得分在轻度水平,分别为13.3% (x¯= 3.30,SD = 2.69)、17.8% (x¯= 2.36,SD = 2.14)和4.4% (x¯= 3.47,SD = 3.12)。32.2%的参与者在一种症状中有消极情绪阶段。通过反向多元线性回归分析发现,年龄对抑郁症状的预测有统计学意义(β = -0.282, p < 0.05)。行走能力对焦虑症状的预测具有统计学意义(β = -0.278, p < 0.05)。年龄和行走能力对应激症状的预测有统计学意义(β = -0.207, p < 05; β = -0.302, p < 05)。结论年龄和行走能力对CLTI患者术前负性情绪状态有影响。
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引用次数: 0
Exploring ethical dilemmas in vascular surgery practice. A Qualitative study 探讨血管外科实践中的伦理困境。定性研究
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.08.003
Evangelos C. Fradelos , Eleni Tsimitrea , Elias Tsagalas , Konstantinos Spanos , Christos Karathanos , George Kouvelos , Athanasios Giannoukas , Anna Mavroforou

Background

Vascular surgery practice presents a variety of ethical dilemmas for vascular surgeons and nurses.

Aim

The present study aimed to explore the ethical dilemmas that healthcare professionals are facing in vascular surgery practice.

Methods

Qualitative study design was employed in this study. Two focus group were conducted using a semi-structured focus group guide, in which ten healthcare professionals participated. Recordings were transcribed, and then analyzed using an inductive content analysis approach.

Results

Analysis identified two primary themes: (1) Balancing patient care and minimizing harm, which included subthemes on patient autonomy and concordance, age and surgical intervention, and end-of-life care with invasive procedures; and (2) Aligning treatment with patient values, which encompassed subthemes on understanding patient preferences and values, and addressing patient concordance, lifestyle modification, and challenges of non- concordant patients. One of the most challenging issues they face daily in clinical practice is balancing patient care with minimal complications.

Conclusions

Vascular healthcare professionals express various concerns during daily vascular surgery practice. The challenges of balancing patient care with minimizing harm along with the patient’s values remain a major issue.
血管外科实践给血管外科医生和护士带来了各种各样的伦理困境。目的探讨医疗专业人员在血管外科实践中所面临的伦理困境。方法采用定性研究设计。采用半结构化焦点小组指南进行了两个焦点小组,其中有10名医疗保健专业人员参加。录音被转录,然后使用归纳内容分析法进行分析。结果分析确定了两个主要主题:(1)平衡患者护理和尽量减少伤害,其中包括患者自主和协调、年龄和手术干预以及有创手术临终关怀的子主题;(2)使治疗与患者价值观保持一致,其中包括理解患者偏好和价值观的子主题,以及解决患者的一致性、生活方式改变和不一致性患者的挑战。他们在临床实践中每天面临的最具挑战性的问题之一是平衡患者护理和最小的并发症。结论血管保健专业人员在日常血管手术实践中表达了各种担忧。平衡患者护理与最小化伤害以及患者价值观的挑战仍然是一个主要问题。
{"title":"Exploring ethical dilemmas in vascular surgery practice. A Qualitative study","authors":"Evangelos C. Fradelos ,&nbsp;Eleni Tsimitrea ,&nbsp;Elias Tsagalas ,&nbsp;Konstantinos Spanos ,&nbsp;Christos Karathanos ,&nbsp;George Kouvelos ,&nbsp;Athanasios Giannoukas ,&nbsp;Anna Mavroforou","doi":"10.1016/j.jvn.2025.08.003","DOIUrl":"10.1016/j.jvn.2025.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Vascular surgery practice presents a variety of ethical dilemmas for vascular surgeons and nurses.</div></div><div><h3>Aim</h3><div>The present study aimed to explore the ethical dilemmas that healthcare professionals are facing in vascular surgery practice.</div></div><div><h3>Methods</h3><div>Qualitative study design was employed in this study. Two focus group were conducted using a semi-structured focus group guide, in which ten healthcare professionals participated. Recordings were transcribed, and then analyzed using an inductive content analysis approach.</div></div><div><h3>Results</h3><div>Analysis identified two primary themes: (1) Balancing patient care and minimizing harm, which included subthemes on patient autonomy and concordance, age and surgical intervention, and end-of-life care with invasive procedures; and (2) Aligning treatment with patient values, which encompassed subthemes on understanding patient preferences and values, and addressing patient concordance, lifestyle modification, and challenges of non- concordant patients. One of the most challenging issues they face daily in clinical practice is balancing patient care with minimal complications.</div></div><div><h3>Conclusions</h3><div>Vascular healthcare professionals express various concerns during daily vascular surgery practice. The challenges of balancing patient care with minimizing harm along with the patient’s values remain a major issue.</div></div>","PeriodicalId":45419,"journal":{"name":"Journal of Vascular Nursing","volume":"43 4","pages":"Pages 198-202"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Health literacy in stroke disease: A systematic review 致编辑的信:卒中疾病的健康素养:一项系统综述
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.07.005
Sankar S. Sailesh MPH
{"title":"Letter to the editor: Health literacy in stroke disease: A systematic review","authors":"Sankar S. Sailesh MPH","doi":"10.1016/j.jvn.2025.07.005","DOIUrl":"10.1016/j.jvn.2025.07.005","url":null,"abstract":"","PeriodicalId":45419,"journal":{"name":"Journal of Vascular Nursing","volume":"43 4","pages":"Page 250"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic abdominal pain: Budd-Chiari syndrome with converging pathologies 慢性腹痛:Budd-Chiari综合征
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.08.007
Jennifer J. DeVries , Holly A. Myers , Jasmine Buffington , Alexis Brant

Introduction

Chronic abdominal pain can be diagnostically challenging, especially when vascular causes like Budd-Chiari Syndrome (BCS) are overlooked. BCS, often linked to prothrombotic conditions such as protein S deficiency, may be further complicated by anatomical anomalies like May-Thurner Syndrome (MTS), leading to significant hepatic congestion and morbidity. This case highlights the need to consider vascular etiologies in patients with hypercoagulable risk factors to ensure timely diagnosis and intervention.

Case Study

A 21-year-old Caucasian female with a complex history including type 1 diabetes mellitus (DM1), protein S deficiency, and prior pulmonary embolism presented with progressive right upper quadrant abdominal pain, early satiety, bloating, and edema. Imaging and venography revealed BCS due to hepatic venous congestion, as well as MTS with chronic thrombus in the left iliac vein and inferior vena cava. She underwent successful iliac vein stenting, which initially improved her symptoms, but later experienced recurrent pain linked to biliary dyskinesia. Gallbladder ultrasound and hepatobiliary iminodiacetic acid (HIDA) scan revealed wall thickening, sludge, and reduced ejection fraction, leading to laparoscopic cholecystectomy. Her symptoms significantly improved postoperatively, highlighting the role of overlapping vascular and hepatobiliary pathologies in chronic abdominal pain.

Conclusion

This case highlights the importance of evaluating vascular causes in young patients with chronic abdominal symptoms, especially when thrombophilia is present. Early identification and coordinated management of BCS, MTS, and associated complications can prevent serious hepatic consequences. A multidisciplinary, vascular-focused approach was essential in achieving a positive outcome in this diagnostically complex presentation.
慢性腹痛的诊断具有挑战性,特别是当血管原因如Budd-Chiari综合征(BCS)被忽视时。BCS通常与蛋白S缺乏症等血栓形成前疾病有关,可能会因may - thurner综合征(MTS)等解剖异常而进一步复杂化,导致严重的肝脏充血和发病率。本病例强调需要考虑高凝危险因素患者的血管病因,以确保及时诊断和干预。病例研究一名21岁白人女性,病史复杂,包括1型糖尿病(DM1)、蛋白S缺乏和既往肺栓塞,表现为进行性右上腹部疼痛、早期饱腹感、腹胀和水肿。影像学及静脉造影显示BCS为肝静脉充血所致,MTS伴左髂静脉及下腔静脉慢性血栓。她接受了成功的髂静脉支架置入术,最初症状有所改善,但后来又出现了与胆道运动障碍相关的复发性疼痛。胆囊超声和肝胆亚胺二乙酸(HIDA)扫描显示胆囊壁增厚、淤积和射血分数降低,导致腹腔镜胆囊切除术。她的术后症状明显改善,突出血管和肝胆重叠病变在慢性腹痛中的作用。结论:本病例强调了在有慢性腹部症状的年轻患者中评估血管原因的重要性,特别是当有血栓形成时。早期识别和协调管理BCS、MTS和相关并发症可以预防严重的肝脏后果。多学科、以血管为中心的方法对于在这种诊断复杂的表现中取得积极的结果至关重要。
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引用次数: 0
Knowledge gaps and quality of life in PAD: The urgent need for comprehensive interventions PAD患者的知识差距和生活质量:迫切需要综合干预措施
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.07.007
Dr. Brijesh Sathian PhD, Javed Iqba RN, MHA, Syed Muhammad Ali MBBS, FCPS
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引用次数: 0
Information for readers 读者资讯
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/S1062-0303(25)00116-5
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引用次数: 0
Comparison of ‘Lite’ reduced compression two-layer bandages for treatment of leg ulcers: Results of the pragmatic, single-centre randomized controlled PEACH trial “Lite”减压双层绷带治疗腿部溃疡的比较:实用的单中心随机对照PEACH试验的结果
IF 1.2 Q3 NURSING Pub Date : 2025-12-01 DOI: 10.1016/j.jvn.2025.07.004
Jane Todhunter , Helen Greenhow , Leon Jonker

Background

In a subset of patients with leg ulcer, reduced compression is indicated to aid wound healing whilst not compromising circulation. It is not clear if there are differences in efficacy between different two-layer compression bandages.

Methods

A single-centre, prospective, non-blinded, randomised, controlled trial was conducted in a Hospital’s vascular department in England to determine 'wound healed’ status at week 12 of treatment. Two ‘Lite' compression bandaged were compared, each providing ∼25 mmHg of pressure. Eligible patients could have leg ulcer of venous or mixed venous-arterial nature, with or without contributing co-morbidities.

Results

In total, 78 patients were randomised. With Andoflex TLC Calamine Lite (also marketed under brand name Coflex, OVIK Health) 18 out of 34 (53%) wounds healed and for Coban2 Lite (3 M) this figure was 15 out of 33 (45%; p-value 0.63, Fisher exact test). A secondary outcome semi-quantitative measure of wound size, PUSH score, did not show a statistical difference between the two bandages either: median score of 0 (inter-quartile range 7) for Andoflex TLC Calamine Lite and 1.5 (inter-quartile range 8) for Coban2 Lite respectively (p-value 0.60, Mann-Whitney U test). Associated leg ulcer symptoms did not differ significantly either.

Conclusions

Andoflex TLC Calamine Lite and Coban2 Lite are non-inferior to each other to up to 20% difference in ‘wound healed’ status at twelve weeks of compression bandage treatment. Any preference in utilisation of one over the other can therefore be dictated by clinician and patient preference. Future research may focus on a comparison of two-layer compression in patients who can tolerate full compression, and/or of two-layer versus hosiery or four-layer devices.
背景:在一部分腿部溃疡患者中,减少压迫有助于伤口愈合,同时不影响血液循环。目前尚不清楚不同的两层压缩绷带的疗效是否有差异。方法在英国一家医院的血管科进行了一项单中心、前瞻性、非盲、随机、对照试验,以确定治疗第12周时的“伤口愈合”状况。比较两种“Lite”压缩绷带,每种提供~ 25 mmHg的压力。符合条件的患者可能患有静脉性或静脉-动脉混合性腿部溃疡,伴有或不伴有合并症。结果78例患者被随机分组。使用Andoflex TLC炉甘石Lite(也以Coflex品牌销售,OVIK Health), 34个伤口中有18个(53%)愈合,使用Coban2 Lite (3 M),这个数字是33个伤口中有15个(45%;p值0.63,Fisher精确检验)。次要结局半定量测量伤口大小,PUSH评分,两种绷带之间也没有统计学差异:Andoflex TLC炉甘石Lite的中位评分为0(四分位数范围7),Coban2 Lite的中位评分为1.5(四分位数范围8)(p值0.60,Mann-Whitney U检验)。相关的腿部溃疡症状也没有显著差异。结论sandoflex TLC炉甘石Lite与Coban2 Lite在压迫绷带治疗12周后的“伤口愈合”状态差异不低于20%。因此,使用其中一种的任何偏好都可以由临床医生和患者的偏好决定。未来的研究可能会集中在两层压缩和/或两层与袜子或四层设备的比较。
{"title":"Comparison of ‘Lite’ reduced compression two-layer bandages for treatment of leg ulcers: Results of the pragmatic, single-centre randomized controlled PEACH trial","authors":"Jane Todhunter ,&nbsp;Helen Greenhow ,&nbsp;Leon Jonker","doi":"10.1016/j.jvn.2025.07.004","DOIUrl":"10.1016/j.jvn.2025.07.004","url":null,"abstract":"<div><h3>Background</h3><div>In a subset of patients with leg ulcer, reduced compression is indicated to aid wound healing whilst not compromising circulation. It is not clear if there are differences in efficacy between different two-layer compression bandages.</div></div><div><h3>Methods</h3><div>A single-centre, prospective, non-blinded, randomised, controlled trial was conducted in a Hospital’s vascular department in England to determine 'wound healed’ status at week 12 of treatment. Two ‘Lite' compression bandaged were compared, each providing ∼25 mmHg of pressure. Eligible patients could have leg ulcer of venous or mixed venous-arterial nature, with or without contributing co-morbidities.</div></div><div><h3>Results</h3><div>In total, 78 patients were randomised. With Andoflex TLC Calamine Lite (also marketed under brand name Coflex, OVIK Health) 18 out of 34 (53%) wounds healed and for Coban2 Lite (3 M) this figure was 15 out of 33 (45%; p-value 0.63, Fisher exact test). A secondary outcome semi-quantitative measure of wound size, PUSH score, did not show a statistical difference between the two bandages either: median score of 0 (inter-quartile range 7) for Andoflex TLC Calamine Lite and 1.5 (inter-quartile range 8) for Coban2 Lite respectively (p-value 0.60, Mann-Whitney <em>U</em> test). Associated leg ulcer symptoms did not differ significantly either.</div></div><div><h3>Conclusions</h3><div>Andoflex TLC Calamine Lite and Coban2 Lite are non-inferior to each other to up to 20% difference in ‘wound healed’ status at twelve weeks of compression bandage treatment. Any preference in utilisation of one over the other can therefore be dictated by clinician and patient preference. Future research may focus on a comparison of two-layer compression in patients who can tolerate full compression, and/or of two-layer versus hosiery or four-layer devices.</div></div>","PeriodicalId":45419,"journal":{"name":"Journal of Vascular Nursing","volume":"43 4","pages":"Pages 167-172"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Vascular Nursing
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