Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy

Journal of Leather Science and Engineering Pub Date : 2023-12-11 DOI:10.1186/s42825-023-00141-7

Jinhong Dong, Tianyou Wang, Haotian Li, Jianhua Zhang, Hengjie Zhang, Weijie Liu, Xinru You, Zhipeng Gu, Yiwen Li, Xianchun Chen, Qiang Fu

{"title":"Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy","authors":"Jinhong Dong, Tianyou Wang, Haotian Li, Jianhua Zhang, Hengjie Zhang, Weijie Liu, Xinru You, Zhipeng Gu, Yiwen Li, Xianchun Chen, Qiang Fu","doi":"10.1186/s42825-023-00141-7","DOIUrl":null,"url":null,"abstract":"<div><p>The development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles (NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline (TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00141-7","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leather Science and Engineering","FirstCategoryId":"1087","ListUrlMain":"https://link.springer.com/article/10.1186/s42825-023-00141-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles (NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline (TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.

Graphical Abstract

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于多酚的抗菌和抗氧化纳米颗粒用于改善腹膜炎治疗

为临床应用开发具有优异生物安全性和生物活性的先进可持续生物医学材料是非常理想的。在本研究中，通过植物多酚与广谱抗生素替加环素（TG）之间的曼尼希反应组装了基于生物质的纳米颗粒（NPs）。制备的 NPs 大小均匀，具有优异的氧化平衡效应、pH 值响应释放特性和抗菌性能。此外，细胞内和体内研究证实，这种 NPs 能够减少细胞的氧化损伤，并显著修复腹膜炎小鼠的组织损伤。这项工作为构建生物质材料治疗感染引起的疾病提供了一种有效的方法和思路。图文摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Leather Science and Engineering 工程技术-材料科学：综合

CiteScore

12.80

自引率

0.00%

发文量