Journal of Leather Science and Engineering最新文献

Detection and cross-linking evaluation of secoiridoid tannins activated with endogenous enzymes 内源性酶活化的环烯醚萜单宁的检测及交联评价

Journal of Leather Science and Engineering

Pub Date : 2026-01-29 DOI: 10.1186/s42825-025-00234-5

Michaela Schroepfer, Antonio d’Errico, Anke Mondschein, Michael Meyer

Environmental and health concerns related to mineral and synthetic tanning agents in leather production are prompting a shift toward sustainable, plant-based alternatives. One group of plant-based tanning agents are the secoiridoids from plants of the Oleaceae family (olive, privet). When their leaves are damaged, secoiridoids are enzymatically deglycosylated to produce aglycones containing aldehyde groups, which are able to cross-link collagen covalently. However, a reliable method to quantify these active aldehyde compounds has been lacking, hindering the application of such tannins. Here, secoiridoid aglycones with aldehyde groups in Olea europaea and Ligustrum vulgare leaf extracts were measured using HPLC-DAD after derivation with 2,4-dinitrophenylhydrazine. Low-temperature extractions (≤ 40 °C) yielded high aldehyde content (up to 17 mg/g extract), attributed to enzymatic activity, while high-temperature extractions (≥ 60 °C) preserved the inactive, glycosylated precursors but contained negligible aldehydes due to enzyme denaturation. The cross-linking potential of the extracts was quantified by testing the denaturation temperature and proportion of covalently bound lysine groups of the hide powder treated with endogenously activated Oleaceae extracts. A strong linear relationship was found between aldehyde content and tanning capacity. The most essential aldehyde-containing substances in the extracts as well as the key parameters for efficient extraction were identified. In conclusion, we introduce a new method to accurately measure aldehyde content and assess the cross-linking potential of Oleaceae plant extracts, and expect to support the development of safer, plant-based tannins for the leather industry.

Graphical Abstract

皮革生产中与矿物和合成鞣剂有关的环境和健康问题促使人们转向可持续的植物基替代品。一组基于植物的鞣制剂是从油科植物（橄榄，女贞）中提取的环烯醚萜。当它们的叶子受损时，二环烯醚萜类化合物被酶解去糖基化，产生含有醛基的苷元，这些苷元能够以共价交联胶原蛋白。然而，一种可靠的方法来量化这些活性醛化合物一直缺乏，阻碍了这类单宁的应用。本研究采用HPLC-DAD法测定了油橄榄和女贞叶提取物经2,4-二硝基苯肼衍生后的乙基环烯醚萜苷元。低温提取（≤40°C）由于酶的活性产生了高醛含量（高达17 mg/g提取物），而高温提取（≥60°C）保留了无活性的糖基化前体，但由于酶变性而含有可忽略不计的醛。通过测定经内源活化的油科植物提取物处理后的皮粉的变性温度和共价赖氨酸基团的比例，量化了提取物的交联电位。醛含量与鞣制能力之间存在较强的线性关系。确定了提取液中最主要的含醛物质以及有效提取的关键参数。总之，我们介绍了一种新的方法来准确测量油科植物提取物的醛含量和评估交联潜力，并期望为皮革工业开发更安全的植物单宁提供支持。图形抽象

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引用次数: 0

Investigation of the tanning mechanism of mycelial leather alternative with genipin and its environmental impact evaluation 用吉尼平替代菌丝体革制革机理的研究及其环境影响评价

Journal of Leather Science and Engineering

Pub Date : 2026-01-12 DOI: 10.1186/s42825-025-00224-7

Xinde Wang, Shan Cao, Shenglong Li, Yitian Sun, Wenhui Lu, Yang Wang

Mycelium has emerged as a promising bio-based material for the development of sustainable leather alternatives, driven by the increasing demand for eco-friendly materials. This work explores the crosslinking mechanism of mycelial leather alternatives treated with genipin tanning, focusing on the interactions between genipin and mycelium fibers. Genipin tanning agent interacts with nitrogen-containing groups and carboxyl groups in mycelial polysaccharides, inducing conformational changes in glycosides and increasing the thermal and structural stability of the mycelial leather alternative. Moreover, the synergistic effect of genipin tanning and glycerol fatliquoring resulted in a more organized and compact structure, with mycelial fibers tightly interwoven. The mycelial leather alternative demonstrated a tensile strength of 6.1 MPa, an elongation at break of 73.1%, as well as excellent thermal stability. The observed improved physical properties were attributed to the crosslinking of genipin with mycelial fibers and hydrogen bond formation between glycerol molecules and the hydroxyl groups on the fibers. Furthermore, the mycelial leather alternative demonstrated strong environmental performance, with more than 50% biodegradation in soil within 50 days. Its incineration produces fewer waste gases compared with traditional sheep leather. This work demonstrates the feasibility of using tanning methods to treat mycelial materials, providing valuable insights for advancing the development of leather alternatives.

Graphical Abstract

由于对环保材料的需求日益增长，菌丝体已成为发展可持续皮革替代品的一种有前途的生物基材料。本研究探讨了皂素鞣制后菌丝皮革替代品的交联机制，重点研究了皂素与菌丝纤维之间的相互作用。吉尼平鞣剂与菌丝多糖中的含氮基团和羧基相互作用，诱导糖苷的构象变化，提高菌丝革替代品的热稳定性和结构稳定性。此外，吉尼平鞣制和甘油加脂的协同作用导致菌丝纤维紧密交织，结构更有组织和紧凑。该菌丝体皮革替代品的抗拉强度为6.1 MPa，断裂伸长率为73.1%，具有良好的热稳定性。观察到的物理性能的改善是由于genipin与菌丝纤维的交联以及甘油分子与纤维上的羟基之间形成氢键。此外，菌丝体皮革替代品表现出很强的环保性能，在土壤中50天内生物降解率超过50%。与传统的羊皮相比，它的焚烧产生的废气更少。这项工作证明了利用鞣制方法处理菌丝体材料的可行性，为推进皮革替代品的开发提供了有价值的见解。图形抽象

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引用次数: 0

Functional pectin-based chromium-free tanning agent with outstanding antimicrobial and yellowing resistance toward sustainable leather processing 功能性果胶基无铬鞣剂，具有优异的抗菌性和抗黄性，适用于可持续皮革加工

Journal of Leather Science and Engineering

Pub Date : 2026-01-07 DOI: 10.1186/s42825-025-00226-5

Xuechuan Wang, Yanting Cai, Xinhua Liu, Xugang Dang

In recent years, chromium-free tanning agents have gained widespread attention as eco-friendly and non-toxic alternatives in the leather industry. However, most commercially available options still suffer from poor stability under wet and heat conditions, lack of antimicrobial properties, and susceptibility to yellowing. Herein, pectin (P) was oxidized by sodium periodate (NaIO₄), green ethylene glycol diglycidyl ether (EGDE) was then used for graft modification, resulting in the successful synthesis of a multifunctional, green oxidized pectin-EGDE (OPE) as a chromium-free tanning agent. Characterization by FTIR, XPS, XRD, and ¹H NMR indicates that OPE has an oxidation value of 68%, epoxide value of 0.34 mol/100 g. Leather tanned with OPE demonstrates remarkably improved properties compared to traditional chromium-free tanning agents (F-90 and TWS), including high thermal stability (shrinkage temperature of 80.5 °C), superior softness (6.3 mm), tensile strength (13.3 MPa), and tear strength (57.3 N/mm). Moreover, the leather tanned with OPE also exhibits significant antimicrobial properties (inhibition zone diameters of 15 mm against S. aureus and 18 mm against E. coli), resistance to yellowing, and biocompatibility. Notably, the biodegradability of the wastewater from OPE tanned leather (BOD₅/COD ≥ 0.3) and its life cycle assessment confirm its unique environmental advantages. Overall, this work uses natural polysaccharides as the raw material to develop a green functional tanning agent, offering an innovative and sustainable solution for advancing the leather industry toward greener development.

Graphical Abstract

近年来，无铬鞣剂作为环保、无毒的替代品在皮革工业中受到广泛关注。然而，大多数商业上可用的选择仍然存在湿热条件下稳定性差，缺乏抗菌性能以及易变黄的问题。本文首先用高碘酸钠（NaIO4）氧化果胶(P)，然后用绿色乙二醇二甘油酯醚（EGDE）接枝改性，成功合成了多功能的绿色氧化果胶-EGDE （OPE）作为无铬鞣剂。FTIR、XPS、XRD和1H NMR表征表明，OPE的氧化值为68%，环氧化物值为0.34 mol/100 g。与传统的无铬鞣剂（F-90和TWS）相比，OPE鞣制的皮革具有显著改善的性能，包括高热稳定性（收缩温度为80.5°C），优异的柔软度（6.3 mm），抗拉强度（13.3 MPa）和撕裂强度（57.3 N/mm）。此外，用OPE鞣制的皮革还表现出显著的抗菌性能（对金黄色葡萄球菌的抑制区直径为15 mm，对大肠杆菌的抑制区直径为18 mm），抗黄变性和生物相容性。值得注意的是，OPE鞣革废水的可生物降解性（BOD₅/COD≥0.3）及其生命周期评估证实了其独特的环境优势。总体而言，本研究以天然多糖为原料，开发绿色功能性鞣剂，为推动皮革工业的绿色发展提供了创新和可持续的解决方案。图形抽象

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引用次数: 0

Recent progress of collagen-based hydrogels for wound healing: a review 胶原基水凝胶用于伤口愈合的研究进展

Journal of Leather Science and Engineering

Pub Date : 2026-01-04 DOI: 10.1186/s42825-025-00225-6

Hongyu Jin, Kun Huang, Rong Zhou, Pengwen Chen, Man Zhang, Yong Jin

Wounds caused by trauma, burns, diabetes, and surgery have threatened human health, and wound management has become a serious clinical challenge and economic burden. Collagen-based hydrogels have good biological activity, biocompatibility, and biodegradability, which make them have broad application prospects as wound dressings in different stages of wound healing and different types of wound healing. In this paper, the advantages and composition characteristics of collagen-based hydrogel dressings and their function mechanism in different wound healing processes such as hemostasis, inflammatory, proliferation, and remodeling are systematically reviewed. To summarize, the main molecular mechanisms of collagen-based hydrogel dressings include the provision of abundant nutrients at various stages, modulation of related cytokines (e.g., CD34, bFGF, and CTGF), inducement of signaling pathways (such as TGF-β/Smad, PI3K/Akt/mTOR), and promotion of the synthesis of ECM components, especially collagen. Thus, throughout the wound healing process, collagen-based hydrogel dressings can accelerate wound hemostasis, reduce inflammation, promote cell proliferation (especially of fibroblasts), aid in angiogenesis, enhance collagen synthesis, accelerate granulation tissue formation and re-epithelialization, and remodel the cytoplasmic matrix, ultimately leading to wound closure. Furthermore, this review discusses the existing problems in clinical application and scale production and outlines the future of development directions in the researches of collagen-based hydrogel dressings combining innovative wound treatment technologies, preparation technologies, and structural design methods, in order to inspire more new advancement and progress.

Graphic Abstract

创伤、烧伤、糖尿病和手术引起的伤口威胁着人类的健康，伤口管理已成为一项严重的临床挑战和经济负担。胶原蛋白基水凝胶具有良好的生物活性、生物相容性和生物降解性，在不同阶段和不同类型的伤口愈合中作为伤口敷料具有广阔的应用前景。本文系统综述了胶原基水凝胶敷料的优点、组成特点及其在止血、炎症、增殖、重塑等不同创面愈合过程中的作用机制。综上所述，胶原基水凝胶敷料的主要分子机制包括：在不同阶段提供丰富的营养物质，调节相关细胞因子（如CD34、bFGF和CTGF），诱导信号通路（如TGF-β/Smad、PI3K/Akt/mTOR），促进ECM成分尤其是胶原的合成。因此，在整个创面愈合过程中，胶原基水凝胶敷料能够加速创面止血、减轻炎症、促进细胞（尤其是成纤维细胞）增殖、促进血管生成、促进胶原合成、加速肉芽组织形成和再上皮化、重塑细胞质基质，最终实现创面愈合。结合创新的创面处理技术、制备技术和结构设计方法，对胶原基水凝胶敷料在临床应用和规模化生产中存在的问题进行了探讨，并展望了未来胶原基水凝胶敷料研究的发展方向，以期启发更多新的进展和进步。图形抽象

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引用次数: 0

Functionalized collagen-based biomaterials via self-assembly: implications for gastrointestinal health 功能性胶原基生物材料的自组装：对胃肠道健康的影响

Journal of Leather Science and Engineering

Pub Date : 2025-12-15 DOI: 10.1186/s42825-025-00217-6

Qin Ma, Yuanmeng He, Yunxiang He, Yue Wu, Qinling Liu, Yulin Guan, Lie Yang, Junling Guo

Collagen, one of the most abundant proteins in human physiology, maintains the morphology and structure of skin and tissues, serving as an important raw material for the repair of damaged tissues. Collagen's widespread application in biomedicine stems from its myriad beneficial properties, including its diverse sourcing, exceptional biocompatibility, sustainability, low immunogenicity, porous nature, and biodegradability. In addition, collagen can self-assemble with other molecules through multiple interactions to form a variety of structures, thereby enhancing its biological functions. In recent years, gastrointestinal diseases have attracted much attention due to their high prevalence and complexity. In this context, collagen-based biomaterials, such as collagen scaffolds and hydrogels, have demonstrated an important role in the treatment of gastrointestinal diseases. This review aims to summarize the research progress of collagen-based biomaterials for the treatment of gastrointestinal diseases in recent years, with a focus on their self-assembly properties and application advantages. Our goal is to explore innovative methods for producing collagen-based biomaterials, aiming to broaden their potential applications and enhance precise therapeutic effects to expand their clinical applications.

Graphical Abstract

胶原蛋白是人体生理中含量最丰富的蛋白质之一，维持着皮肤和组织的形态和结构，是修复受损组织的重要原料。胶原蛋白在生物医学上的广泛应用源于其无数的有益特性，包括其来源的多样性、卓越的生物相容性、可持续性、低免疫原性、多孔性和生物降解性。此外，胶原蛋白可以通过多种相互作用与其他分子自组装，形成多种结构，从而增强其生物学功能。近年来，胃肠道疾病因其高发性和复杂性而备受关注。在这种情况下，胶原蛋白为基础的生物材料，如胶原蛋白支架和水凝胶，已经在胃肠道疾病的治疗中发挥了重要作用。本文综述了近年来胶原基生物材料治疗胃肠道疾病的研究进展，重点介绍了胶原基生物材料的自组装特性和应用优势。我们的目标是探索创新的胶原基生物材料的生产方法，旨在拓宽其潜在的应用范围，提高其精确的治疗效果，以扩大其临床应用。图形抽象

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引用次数: 0

An environmentally benign chelative biosorbent for efficient adsorption remediation of tetracycline contamination 一种高效吸附修复四环素污染的环境友好型螯合生物吸附剂

Journal of Leather Science and Engineering

Pub Date : 2025-12-11 DOI: 10.1186/s42825-025-00230-9

Xueling Yi, Duanyang Luo, Siqi Liu, Yanxu Chen, Jin Guo, Qingyu Yan, Hui Mao

Antibiotic contamination has been a concerning environmental issue due to its potential threats to the development of drug-resistant bacteria and genes. Plant polyphenols were employed as biomolecule chelating ligands to graft onto collagen fibers, followed by the chelative immobilization of Fe ions. The as-obtained environmentally benign chelative biosorbent (CFBT-Fe) features a classic fibrous structure, excellent distribution and reservation of Fe ions, increased thermal stability, and inhibited swelling behavior owing to the introduction of bayberry tannin. An exceptional adsorption capacity of tetracycline on CFBT-Fe is exhibited across a broad pH range (3.0–10.0). Optimal adsorption capacity (31.30 mg/g) occurs at neutral pH 7.0, which is higher than many other similar biosorbents reported in the literature. The CFBT-Fe exhibits exceptional recyclability with sixth-cycle adsorption performance at 25.27 mg/g. The environmentally benign coordinative biosorbent is considered a promising candidate for the effective adsorptive removal of tetracycline from aquatic environments across a wide pH range.

Graphical Abstract

抗生素污染已成为一个令人关注的环境问题，因为它对耐药细菌和耐药基因的发展具有潜在的威胁。将植物多酚作为生物分子螯合配体移植到胶原纤维上，然后对铁离子进行螯合固定。所制得的环境友好型螯合生物吸附剂（CFBT-Fe）具有经典的纤维结构，铁离子的良好分布和保留，提高了热稳定性，并且由于杨梅单宁的引入而抑制了膨胀行为。在较宽的pH范围内（3.0-10.0），四环素在CFBT-Fe上表现出优异的吸附能力。最佳吸附量（31.30 mg/g）发生在中性pH 7.0时，高于文献中报道的许多其他类似的生物吸附剂。CFBT-Fe具有良好的可回收性，吸附量为25.27 mg/g。这种环境友好的配位生物吸附剂被认为是一种很有前途的候选材料，可以在很宽的pH范围内有效吸附去除水生环境中的四环素。图形抽象

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引用次数: 0

Recent progress in protein-based food packaging films 蛋白基食品包装薄膜的研究进展

Journal of Leather Science and Engineering

Pub Date : 2025-12-01 DOI: 10.1186/s42825-025-00231-8

Jiaqi Lu, Qunna Xu, Jianzhong Ma, Xiaoyu Xu, Yuan Zhao, Yao Pu, Yanting Deng, Kai Yan, Yan Zong, Qianqian Fan

With the increase in global plastic pollution and the growing need for sustainable development, the food packaging industry is experiencing an unprecedented paradigm shift. New food packaging technologies that address environmental concerns while maintaining food quality and safety are continuously being developed. In this regard, biodegradable films derived from animal and plant proteins have shown considerable potential. These films show advantages due to their sustainable sourcing, excellent film-forming properties, and complete biodegradability and are thus suitable for the packaging industry. This review discusses various types of biodegradable protein-based packaging films, their preparation techniques, and their applications within the food packaging sector. Moreover, it comprehensively explores the potential challenges and opportunities in smart food packaging based on these films. Accordingly, this review highlights the potential of protein-based packaging films to emerge as dominant materials in food packaging.

Graphical Abstract

随着全球塑料污染的增加和可持续发展的需求日益增长，食品包装行业正在经历前所未有的范式转变。新的食品包装技术，解决环境问题，同时保持食品质量和安全正在不断发展。在这方面，从动物和植物蛋白中提取的可生物降解薄膜显示出相当大的潜力。这些薄膜由于其可持续性采购、优异的成膜性能和完全的生物降解性而具有优势，因此适用于包装工业。本文综述了各种生物可降解蛋白基包装薄膜的制备技术及其在食品包装领域的应用。并以这些影片为基础，全面探讨了智能食品包装的潜在挑战与机遇。因此，这篇综述强调了蛋白质基包装薄膜在食品包装中作为主导材料出现的潜力。图形抽象

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引用次数: 0

Correction: Organophosphorus pollutant degradationin wastewater using the microscale zero‑valent iron/O3 process: optimization, performance, and mechanism 修正：微尺度零价铁/O3工艺降解废水中有机磷污染物：优化、性能及机理

Journal of Leather Science and Engineering

Pub Date : 2025-11-24 DOI: 10.1186/s42825-025-00229-2

Zhenpeng Cai, Yujia Xiang, Boyi Cong, Yang Liu, Shuai Yang, Ningruo Wang, Heng Zhang, Yuzhong Wang, Bo Lai

引用次数: 0

The degradation rate of collagen-based hydrogels regulates chondrogenic differentiation of bone marrow mesenchymal stem cells 胶原基水凝胶的降解速率调节骨髓间充质干细胞的成软骨分化

Journal of Leather Science and Engineering

Pub Date : 2025-11-19 DOI: 10.1186/s42825-025-00221-w

Qingli Liu, Wenling Dai, Yongli Gao, Shikui Li, Xingchen Zhao, Hengxing Jia, Yanfei Tan, Likun Guo, Yujiang Fan, Xingdong Zhang

Dynamic degradation of three-dimensional (3D) scaffolds is essential for cellular extracellular matrix (ECM) remodeling and neo-tissue formation. Collagen I (Col I)-based hydrogel scaffolds, which exhibit chondroinductive properties, have important applications in cartilage tissue engineering. However, Col I hydrogels are susceptible to rapid degradation, thereby limiting their application in tissue engineering. It remains unclear whether the degradation rate of Col I hydrogels influences their chondroinductive capacity. The present research aimed to investigate the effects of degradation rate of Col I hydrogels on the chondrogenic differentiation of mesenchymal stem cells (MSCs). In this work, methacrylated collagen (MC) with varying degrees of substitution (DS) was synthesized by reacting Col I with methacrylic anhydride (MA) and designated as MC10, MC30, MC50 and MC80, respectively. The corresponding collagen-based hydrogels with different degradation rates were fabricated following incubation and photo-crosslinking. Although MA modification did not significantly alter the characteristic conformation of collagen molecules, the density of the internal fiber network within the hydrogels formed by MCs increased with the increase of grafting degree. The degradation rate of MC hydrogels was inversely related to the extent of collagen methacrylation. A higher degree of modification resulted in a lower proliferation rate of MSCs encapsulated within the hydrogels. MSCs were encapsulated in these collagen-based hydrogels and underwent chondrogenesis under both in vitro and in vivo conditions. The degradation rate of collagen-based hydrogels was found to significantly influence both the contraction of hydrogel-MSC constructs and cell proliferation. Both MC10 and MC30 hydrogels, with suitably moderated degradation rates, more efficiently promoted chondrogenic differentiation of MSCs in both in vitro culture and in vivo ectopic implantation models. Furthermore, the degradation kinetics of MC30 hydrogels more closely matched the tempo of in vivo chondrogenesis, and accordingly, MC30 constructs demonstrated enhanced repair capacity in models of in situ cartilage regeneration. Therefore, the degradation rate of collagen-based hydrogels serves as a dynamic cue that influences chondrogenesis by modulating the tissue-inductive capacity of the scaffolds. Thus, precise regulation of scaffold degradation rate is essential for the rational design of cartilage tissue engineering scaffolds.

Graphical abstract

三维支架的动态降解是细胞外基质（ECM）重塑和新组织形成的必要条件。胶原蛋白（Col I）基水凝胶支架具有诱导软骨的特性，在软骨组织工程中有着重要的应用。然而，Col I水凝胶容易快速降解，从而限制了它们在组织工程中的应用。目前尚不清楚coli水凝胶的降解速率是否会影响其诱导软骨的能力。本研究旨在探讨Col I水凝胶降解速率对间充质干细胞（MSCs）成软骨分化的影响。本文通过Col I与甲基丙烯酸酐（MA）反应合成了不同取代度的甲基丙烯酸胶原（MC），分别命名为MC10、MC30、MC50和MC80。通过培养和光交联制备相应的降解率不同的胶原基水凝胶。虽然MA修饰没有显著改变胶原分子的特征构象，但mc形成的水凝胶内部纤维网络密度随着接枝程度的增加而增加。MC水凝胶的降解速率与胶原甲基丙烯酸化程度呈负相关。修饰程度越高，水凝胶内的间充质干细胞增殖率越低。MSCs被包裹在这些胶原基水凝胶中，并在体外和体内条件下进行软骨形成。胶原基水凝胶的降解速率对水凝胶-间充质干细胞构建的收缩和细胞增殖均有显著影响。在体外培养和体内异位植入模型中，MC10和MC30水凝胶在适当调节降解速率的情况下，都能更有效地促进间充质干细胞的软骨分化。此外，MC30水凝胶的降解动力学更接近体内软骨形成的速度，因此，MC30构建物在原位软骨再生模型中表现出增强的修复能力。因此，胶原基水凝胶的降解率作为一个动态线索，通过调节支架的组织诱导能力来影响软骨形成。因此，精确调控支架降解速率对于软骨组织工程支架的合理设计至关重要。图形抽象

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引用次数: 0

Injectable hydrogels with tailored recombinant humanized collagen type I for the repair of damaged hearts by remodeling the myocardial microenvironment 可注射的重组人源I型胶原蛋白水凝胶通过重塑心肌微环境修复受损心脏

Journal of Leather Science and Engineering

Pub Date : 2025-11-18 DOI: 10.1186/s42825-025-00212-x

Cheng Hu, Wenqi Liu, Jian Wang, Chen Hua, Linyu Long, Xia Yang, Lu Lu, Yun Zhu, Li Yang, Yunbing Wang, Xingdong Zhang

Heart failure or myocardial infarction (MI) is among the leading causes of death worldwide. However, current therapeutic procedures, including pharmacological interventions and ventricular assist devices, are unable to reverse the pathological changes and regenerate the injured cardiac tissue. Here, tailored recombinant humanized collagen type I (rhCol I) with high bioactivity for myocardial tissue-related cells was loaded into injectable hydrogels to construct a microenvironment favorable for angiogenesis, myocardial tissue repair and the restoration of heart function after MI. rhCol I-loaded hydrogels (gel@rhCol I) had a good response to the MI microenvironment, which indicated that they can release rhCol I for MI treatment. In vitro and in vivo results showed that the gel@rhCol I is able to effectively promote myocardial tissue repair and restore cardiac function after MI by inhibiting cell apoptosis, downregulating pro-inflammatory factors and promoting angiogenesis. In conclusion, injectable hydrogel based on tailored rhCol I exhibited great potential in the repair of damaged myocardial tissue. More importantly, the discovery of the mechanism of rhCol I promoting the repair of damaged myocardial tissue will broaden the clinical application of rhCol I for MI or heart failure treatment.

Graphic Abstract

心力衰竭或心肌梗死（MI）是世界范围内死亡的主要原因之一。然而，目前的治疗方法，包括药物干预和心室辅助装置，无法逆转病理变化和再生受损的心脏组织。本研究将对心肌组织相关细胞具有高生物活性的重组人源I型胶原（rhCol I）装载到可注射的水凝胶中，构建有利于心肌梗死后血管生成、心肌组织修复和心脏功能恢复的微环境。装载rhCol I的水凝胶（gel@rhCol I）对心肌梗死微环境有良好的反应，表明它们可以释放rhCol I用于心肌梗死治疗。体外和体内实验结果表明，gel@rhCol I能够通过抑制细胞凋亡、下调促炎因子、促进血管生成等方式，有效促进心肌梗死后心肌组织修复，恢复心功能。综上所述，基于rhCol I的可注射水凝胶在修复受损心肌组织方面具有很大的潜力。更重要的是，rhCol I促进受损心肌组织修复机制的发现将拓宽rhCol I在心肌梗死或心力衰竭治疗中的临床应用。图形抽象

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引用次数: 0