The 5-/12-lipoxygenase-BLT2 cascade induces elevated expression of c-Myc, thus mediating the proliferation and migration of KRAS mutant colorectal cancer cells

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-12-11 DOI:10.1080/19768354.2023.2290031
Jaein Park, Jae-Hyun Jang, Jun-Dong Wei, Jae-Hong Kim
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Abstract

Colorectal cancer (CRC) is the most common malignant tumor and one of the leading causes of cancer-related death worldwide. Oncogene KRAS is a commonly mutated in CRC and plays crucial roles in the...
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5-/12 脂氧合酶-BLT2 级联反应诱导 c-Myc 表达升高,从而介导 KRAS 突变结直肠癌细胞的增殖和迁移
结肠直肠癌(CRC)是最常见的恶性肿瘤,也是全球癌症相关死亡的主要原因之一。癌基因 KRAS 是 CRC 中常见的突变基因,在 CRC 的发生和发展过程中起着至关重要的作用。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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