[Basal membrane unevenness in glomerular amyloidosis].

T Tóth
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Abstract

Author has studied in 5 needle-biopsy and 25 autopsy samples the wall unevennesses of the glomerular capillary loops developing in kidney amyloidosis. In all cases subepithelial spikes consisting of parallel amyloid fibres were observed. In half of the cases, similar structures occurred also subendothelially. In silver-stained preparations they were readily identified by their increased argyrophilia. In all cases nodular features composed of irregular amyloid fibres were subendothelially present resulting in a considerable narrowing of the lumen. The spikes and nodules causing the unevenness of the basement membrane are of diagnostic value in glomerular amyloidosis.

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[肾小球淀粉样变性的基底膜不均匀]。
作者对肾淀粉样变性患者肾小球毛细血管袢壁不均匀的5例穿刺活检和25例尸检标本进行了研究。在所有病例中均观察到由平行淀粉样蛋白纤维组成的上皮下尖峰。在一半的病例中,类似的结构也发生在内皮下。在染银的制剂中,它们的嗜银性增加,很容易被识别出来。在所有病例中,不规则淀粉样纤维组成的结节特征在内皮下存在,导致管腔明显变窄。引起基底膜不均匀的突起和结节对肾小球淀粉样变性有诊断价值。
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