Morphologiai es igazsagugyi orvosi szemle最新文献

Authors studied changes of femoral vein developed by the effect of examinations experimental lymphoedema in dogs. Light and electronmicroscopic were performed from femoral vein of animals killed on 3rd and 14th postoperative day, and biomechanical examinations were done too from dogs killed on 14th postoperative day. In vessel wall edema, fibrosis, and in valves infiltration consisting of macrophages, neutrophilic granulocytes and of mesenchymal cells were observed. Biomechanical examinations did not show significant deviation. Their results suggest the possibility that extremital lymphoedema also in man may contribute to development of varicosity or to its aggravation. Experimental lymphoedema of lower limb of dog can be proposed as model experiment to the complex study of pathogenesis of development of varix.

Morphological changes of adenoid tissue associated with morbilli are known. However, it is less known that the disease may start with symptoms of acute appendicitis and on the basis of histological picture morbilli can be raised or rendered probable, respectively, before appearance of typical clinical symptoms. Among morbilli cases of recently increased number the later developed morbilli was diagnosed from appendix in an appendectomy performed on a patient being in prodormal stage.

Authors studied the effect of Silibinin of antioxidative effect on cholesterin sclerosis of rabbits. Qualitative analysis of aorta sections, macroscopic and microscopic morphometric examination of aorta were the applied methods. Their results seem to show that Silibinin has a favourable influence on cholesterin sclerosis. According to their opinion only joint use of qualitative and quantitative macroscopic and microscopic methods can provide basis for really accurate judgment of any atheromatose change.

Adenomatoide tumor of uterine is reported on the basis of study of three surgical preparations. Tumors were detected as causal finding in uterines removed for other changes. The tumor can be a histopathologic diagnostic problem. It is likely considered to be of mesothelial origin. Its two forms are separated; in one also smooth muscle cells take part in growth.

Authors examined cells participating in intimaproliferation in transplantation arteriopathy ultrastructurally in needle and wedge biopsy material from 40 transplanted kidneys, and immunohistochemically in 10 cases. In early biopsies--even in two control kidneys--it could be observed that the smooth muscle cells of media are in direct contact with endothel cells by their small processes. Processes can fulfil a receptor function and can transmit endothel noxa to smooth muscle cells. Smooth muscle cells of media react to endothel damage caused by rejection with migration to intima and during this period they are transformed to myofibroblasts (myointimal cells). In the mean time inflammatory cells (mainly macrophages, helper and cytotoxic cells in lower number) from the lumen infiltrate the intima, and mediators, enzymes released from them can inspire smooth muscle cells to further proliferation, migration to intima and transformation to myofibroblast. To effect of mediators (gamma interferon) released from inflammatory cells, the myointimal cells during rejection will press out 2nd class transplantation antigens (HLA-DR), and as vicious circle it further aggravates immune reply to graft, causing vascular damage, intimaproliferation.

Authors examined the effect of D-penicillamin (Pw) on liver cirrhosis induced by chronic CCl4 and phenobarbital (Pb) treatment in Fischer 344 rats. Morphometric analysis of quantity of connective tissue fibres did not show decrease on the effect of Pe treatment. Quantity of hydroxiproline, which is one of the parameters of coll ahen decrease, did not change significantly on effect of drug, but only compared to CCl4 and Pb treated control. Quantity of glycosaminoglycan showed increase following Pe treatment. Lymphocyte stimulation by Con-A was different in CCl4 and Pb and Pe treated groups, respectively. According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful. It seems that Pe is effective only in forms of cirrhosis accompanied by significant copper accumulation, by decrease of toxic effects of copper.

Author surveys literature of pathology and medical informatics of last 25 years regarding pathological information systems. He studies changes of used hardware and software means related to development of computer technique. Some issues of use of pathological informatics in Hungary are also touched on basis of literature.

Ionic stain-binding is influenced by number of acid and basic groups, their dissociation equilibrium coefficient and isoelectric point of proteins, respectively, and by permeability, on tissue side and acid and basic character, respectively, ionic volume, isochronic and succedaneous way of application, respectively, and hydrogene ion concentration of solution on side of stain. With joint or sequent use of acid stains of different ionic volume, permeability order of certain tissue elements, their relative permeability can be determined.