Ze-dong Nan , Yi-dong Zhu , Chao-fan Deng , Guo-dong Jiang , Zhen-zhen Wang , Chong-long Li , Xiao-li Ma , Zhi-Bo Jiang
{"title":"Nitrogenous chemical constituents and their antitumor activities evaluation in vitro from the aerial parts of Corydalis impatiens (pall.) Fisch","authors":"Ze-dong Nan , Yi-dong Zhu , Chao-fan Deng , Guo-dong Jiang , Zhen-zhen Wang , Chong-long Li , Xiao-li Ma , Zhi-Bo Jiang","doi":"10.1080/14786419.2023.2291704","DOIUrl":null,"url":null,"abstract":"<div><div>Four new compounds, impatienines E-H (<strong>1</strong>–<strong>4</strong>), together with 18 known ones (<em>R</em>)-<em>N</em>-methylcoclaurine (<strong>5</strong>), impatienine I (<strong>6</strong>), thalifoline (<strong>7</strong>), iseluxine (<strong>8</strong>), pisoquinoline (<strong>9</strong>), corydaldine (<strong>10</strong>), northalifoline (<strong>11</strong>), noroxyhydrastinine (<strong>12</strong>), 6,7-methylenedioxy-1(2<em>H</em>)-isoquinolinone (<strong>13</strong>), <em>N</em>-methylcorydaldine (<strong>14</strong>), oxyhydrastinine (<strong>15</strong>), corypalline (<strong>16</strong>), <em>N</em>-<em>trans</em>-feruloylmethoxytyramine (<strong>17</strong>), <em>N</em>-<em>trans</em>-feruloyldopamine (<strong>18</strong>), <em>N</em>-<em>trans</em>-feruloyltyramine (<strong>19</strong>), <em>N</em>-<em>trans</em>-sinapoyltyramine (<strong>20</strong>), <em>N</em>-<em>cis</em>-feruloyltyramine (<strong>21</strong>), <em>N</em>-<em>cis</em>-sinapoyltyramine (<strong>22</strong>) were obtained from the aerial parts of <em>Corydalis impatiens</em> (pall.) Fisch. Their structures were elucidated by extensive spectroscopic analysis (1D- and 2D-NMR, HR-ESIMS, IR, UV) and/or comparison with reported literature. The inhibitory effects of these isolates were also evaluated against the growth of cancer cells (A549, H1299 and HepG2). Compounds <strong>2</strong> and <strong>4</strong> showed significant inhibitory effect on HepG2 cancer cells with IC<sub>50</sub> values of 8.62, 8.32 μM, respectively (positive control cisplatin: IC<sub>50</sub>, 6.32 μM). Compounds <strong>22</strong> and <strong>4</strong> exhibited moderate inhibitory effects against A549 cancer cells, and the IC<sub>50</sub> values were 7.78 and 12.54 μM, respectively (positive control cisplatin: IC<sub>50</sub>, 1.83 μM).</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 5","pages":"Pages 1027-1038"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923023446","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Four new compounds, impatienines E-H (1–4), together with 18 known ones (R)-N-methylcoclaurine (5), impatienine I (6), thalifoline (7), iseluxine (8), pisoquinoline (9), corydaldine (10), northalifoline (11), noroxyhydrastinine (12), 6,7-methylenedioxy-1(2H)-isoquinolinone (13), N-methylcorydaldine (14), oxyhydrastinine (15), corypalline (16), N-trans-feruloylmethoxytyramine (17), N-trans-feruloyldopamine (18), N-trans-feruloyltyramine (19), N-trans-sinapoyltyramine (20), N-cis-feruloyltyramine (21), N-cis-sinapoyltyramine (22) were obtained from the aerial parts of Corydalis impatiens (pall.) Fisch. Their structures were elucidated by extensive spectroscopic analysis (1D- and 2D-NMR, HR-ESIMS, IR, UV) and/or comparison with reported literature. The inhibitory effects of these isolates were also evaluated against the growth of cancer cells (A549, H1299 and HepG2). Compounds 2 and 4 showed significant inhibitory effect on HepG2 cancer cells with IC50 values of 8.62, 8.32 μM, respectively (positive control cisplatin: IC50, 6.32 μM). Compounds 22 and 4 exhibited moderate inhibitory effects against A549 cancer cells, and the IC50 values were 7.78 and 12.54 μM, respectively (positive control cisplatin: IC50, 1.83 μM).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
