Eatemad A. Awadalla, Safinaz E. El-Baga, Samia A. Gabr, Wafaa I. Gelany, Rana A. Ali
{"title":"Biochemical and Histological Studies on the Protective Effects of Curcumin against Acetamiprid-Induced Hepato-Renal Toxicity","authors":"Eatemad A. Awadalla, Safinaz E. El-Baga, Samia A. Gabr, Wafaa I. Gelany, Rana A. Ali","doi":"10.1134/s1990519x23060032","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The present study aims to investigate the possible liver and kidney toxicity mechanisms of prolonged acetamiprid (ACMP) induction and the protective effects of co-treatment with curcumin (Cur) on ACMP-induced liver and kidney complications. Forty male albino Wistar rats were divided into four groups (n = 10 in each). Group I (the control group) received 1% dimethyl sulfoxide, group II (the Cur-group) received Cur (100 mg/kg/day), group III (the ACMP-group) received acetamiprid (40 mg/kg/day), and group IV the (ACMP + Cur)-group received ACMP (40 mg/kg/day) plus Cur (100 mg/kg/day) for 30 days. Tissue samples from the liver and kidney were collected and prepared for biochemical, histological, and immunohistochemical analysis. Our results showed a significant increase in total oxidative stress levels and a significant decrease in the total antioxidant capacity in the liver and kidney tissue of the ACMP-group compared with those of the control group (<i>p</i> < 0.05 for all parameters). Also, the ACMP-group showed a disturbance in the structure of the liver and kidneys of rats compared to that of the control group. However, the (ACMP + Cur)-group showed significantly lower total oxidative stress levels and significantly higher levels of total antioxidant capacity than the ACMP-group, with histological similarity to the control group. Total oxidative stress and total antioxidant capacity could clarify the ACMP-induced hepatic and renal toxicity mechanisms that have been attenuated by Cur co-administration. These findings proposed that the co-administration of Cur with ACMP attenuated its toxicity by reducing oxidative stress and improving antioxidant capacity, indicating the role of Cur as an antioxidant in mitigating ACMP-toxicity.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x23060032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The present study aims to investigate the possible liver and kidney toxicity mechanisms of prolonged acetamiprid (ACMP) induction and the protective effects of co-treatment with curcumin (Cur) on ACMP-induced liver and kidney complications. Forty male albino Wistar rats were divided into four groups (n = 10 in each). Group I (the control group) received 1% dimethyl sulfoxide, group II (the Cur-group) received Cur (100 mg/kg/day), group III (the ACMP-group) received acetamiprid (40 mg/kg/day), and group IV the (ACMP + Cur)-group received ACMP (40 mg/kg/day) plus Cur (100 mg/kg/day) for 30 days. Tissue samples from the liver and kidney were collected and prepared for biochemical, histological, and immunohistochemical analysis. Our results showed a significant increase in total oxidative stress levels and a significant decrease in the total antioxidant capacity in the liver and kidney tissue of the ACMP-group compared with those of the control group (p < 0.05 for all parameters). Also, the ACMP-group showed a disturbance in the structure of the liver and kidneys of rats compared to that of the control group. However, the (ACMP + Cur)-group showed significantly lower total oxidative stress levels and significantly higher levels of total antioxidant capacity than the ACMP-group, with histological similarity to the control group. Total oxidative stress and total antioxidant capacity could clarify the ACMP-induced hepatic and renal toxicity mechanisms that have been attenuated by Cur co-administration. These findings proposed that the co-administration of Cur with ACMP attenuated its toxicity by reducing oxidative stress and improving antioxidant capacity, indicating the role of Cur as an antioxidant in mitigating ACMP-toxicity.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
