{"title":"Functional Interactions of BAF and LEM Proteins in the Formation of Germ Cells","authors":"I. O. Bogolyubova, D. S. Bogolyubov","doi":"10.1134/s1990519x23060044","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Restoration of the nuclear structure after cell division requires specific interactions between the integral proteins of the inner nuclear membrane, which have a special LAP2-emerin-MAN1 domain (LEMD), nuclear lamina proteins (lamins), and the conserved barrier-to-autointegration factor (BAF) protein, which acts as a central link in these interactions that provide the topological relationships of chromatin and nuclear envelope. The dynamic transformations of these protein ensembles in the mitotic cycle have been characterized in detail at the molecular level; however, less attention is paid to developing germ cells undergoing meiotic divisions, despite the fact that their nuclei (especially in the case of diplotene oocytes) differ significantly in structure from somatic cells. This review summarizes the still relatively scarce experimental data proving the significance of functional interactions between BAF and LEMD proteins for gamete formation, from the isolation of germline cells to the transformation of haploid spermatids into morphologically mature spermatozoa.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"105 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x23060044","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Restoration of the nuclear structure after cell division requires specific interactions between the integral proteins of the inner nuclear membrane, which have a special LAP2-emerin-MAN1 domain (LEMD), nuclear lamina proteins (lamins), and the conserved barrier-to-autointegration factor (BAF) protein, which acts as a central link in these interactions that provide the topological relationships of chromatin and nuclear envelope. The dynamic transformations of these protein ensembles in the mitotic cycle have been characterized in detail at the molecular level; however, less attention is paid to developing germ cells undergoing meiotic divisions, despite the fact that their nuclei (especially in the case of diplotene oocytes) differ significantly in structure from somatic cells. This review summarizes the still relatively scarce experimental data proving the significance of functional interactions between BAF and LEMD proteins for gamete formation, from the isolation of germline cells to the transformation of haploid spermatids into morphologically mature spermatozoa.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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