{"title":"Phosphorus abnormalities in a paediatric intensive care unit in North India","authors":"Taruna Vijaywargiya, Satyajeet Maurya, Sitikant Mohapatra","doi":"10.4038/sljch.v52i4.10619","DOIUrl":null,"url":null,"abstract":"Introduction: Critical illness triggers severe acute phase response which is associated with several metabolic derangements. Serum phosphorus level abnormalities are common among them and go unnoticed in sick children.Objectives: To determine the prevalence of phosphorus abnormalities in sick children admitted to the paediatric intensive care unit (PICU) and its association with various clinical outcomes.Method: We conducted a prospective, non-interventional study at a PICU in North India. During an 18-month period we investigated the incidence of phosphorus abnormalities in patients admitted to the PICU on admission and followed the course at day 3 and day 7 during their stay.Results: The prevalence of phosphorus level abnormalities was 44.2% on admission to PICU; 34.9% patients had hypophosphataemia while 9.3% had hyperphosphataemia. Hypophosphataemia was significantly associated with severe malnutrition (p=0.041) while hyperphosphataemia was associated with organ failure (p=<0.001). Although the need for mechanical ventilation, duration of PICU stay and mortality were higher in hypophosphataemic patients and PRISM score was higher in hyperphosphataemic patients, these differences were not statistically significant. Changes in the baseline phosphorus levels after PICU stays of 3 days (p=0.346) and of 7 days (p=0.782) were not statistically significant.Conclusions: Phosphorus abnormalities were highly prevalent in ill children admitted in the PICU. Hypophosphatemia was more common and was significantly associated with severe malnutrition while hyperphosphatemia was significantly associated with organ failure.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":"135 51","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sri Lanka Journal of Child Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4038/sljch.v52i4.10619","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Critical illness triggers severe acute phase response which is associated with several metabolic derangements. Serum phosphorus level abnormalities are common among them and go unnoticed in sick children.Objectives: To determine the prevalence of phosphorus abnormalities in sick children admitted to the paediatric intensive care unit (PICU) and its association with various clinical outcomes.Method: We conducted a prospective, non-interventional study at a PICU in North India. During an 18-month period we investigated the incidence of phosphorus abnormalities in patients admitted to the PICU on admission and followed the course at day 3 and day 7 during their stay.Results: The prevalence of phosphorus level abnormalities was 44.2% on admission to PICU; 34.9% patients had hypophosphataemia while 9.3% had hyperphosphataemia. Hypophosphataemia was significantly associated with severe malnutrition (p=0.041) while hyperphosphataemia was associated with organ failure (p=<0.001). Although the need for mechanical ventilation, duration of PICU stay and mortality were higher in hypophosphataemic patients and PRISM score was higher in hyperphosphataemic patients, these differences were not statistically significant. Changes in the baseline phosphorus levels after PICU stays of 3 days (p=0.346) and of 7 days (p=0.782) were not statistically significant.Conclusions: Phosphorus abnormalities were highly prevalent in ill children admitted in the PICU. Hypophosphatemia was more common and was significantly associated with severe malnutrition while hyperphosphatemia was significantly associated with organ failure.
简介:危重疾病引发严重的急性期反应,这与几种代谢紊乱有关。血清磷水平异常在他们中很常见,而在患病儿童中却未被注意到。目的:确定住院儿科重症监护病房(PICU)患病儿童磷异常的患病率及其与各种临床结果的关系。方法:我们在印度北部的PICU进行了一项前瞻性、非介入性研究。在18个月的时间里,我们调查了PICU入院患者磷异常的发生率,并在住院期间的第3天和第7天随访。结果:入PICU时磷水平异常发生率为44.2%;34.9%的患者低磷血症,9.3%的患者高磷血症。低磷血症与严重营养不良显著相关(p=0.041),而高磷血症与器官衰竭相关(p=<0.001)。虽然低磷血症患者的机械通气需求、PICU住院时间和死亡率较高,高磷血症患者的PRISM评分较高,但这些差异无统计学意义。PICU停留3 d (p=0.346)和7 d (p=0.782)后基线磷水平的变化无统计学意义。结论:磷异常在PICU住院患儿中非常普遍。低磷血症更为常见,与严重营养不良显著相关,而高磷血症与器官衰竭显著相关。
期刊介绍:
This is the only journal of child health in Sri Lanka. It is designed to publish original research articles and scholarly articles by recognized authorities on paediatric subjects. It is distributed widely in Sri Lanka and bears the ISSN number 1391-5452 for the print issues and e-ISSN 2386-110x for the electronic version in the internet. The journal is published quarterly and the articles are reviewed by both local and foreign peers. The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka.