Advancements in modifying the efficacy of immunotherapies through the thermal effects of nanomaterials

Lan Lei , Pengyuan Liu , Wu Jing , Zhibing Wu
{"title":"Advancements in modifying the efficacy of immunotherapies through the thermal effects of nanomaterials","authors":"Lan Lei ,&nbsp;Pengyuan Liu ,&nbsp;Wu Jing ,&nbsp;Zhibing Wu","doi":"10.1016/j.ntm.2023.100022","DOIUrl":null,"url":null,"abstract":"<div><p>Tumor immunotherapy represents an intricate approach to combat tumors by modifying the immune microenvironment within the body. Nevertheless, the limited success rate and potential induction of systemic toxic reactions associated with immunotherapy introduce uncertainty regarding its therapeutic effectiveness. Nanoparticles (NPs) exhibit multifaceted applications as therapeutic and diagnostic tools, enabling precise delivery of various immunotherapeutic agents and monitoring of tissue cellular responses. These capabilities facilitate the dynamic assessment of factors influencing immune activity, thereby optimizing future treatment strategies. The utilization of multimodal anti-tumor therapies has paved the way for the induction of potent immune responses, while simultaneously minimizing adverse effects and facilitating the monitoring of immune activities.This review aims to provide an overview of this emerging field and highlight new technologies for next-generation immunotherapy. The current therapeutic approaches are introduced, and the mechanism of action of nanomaterials in combination with thermotherapy to stimulate systemic immune responses is explored. Furthermore, recent advancements in synergistic immunotherapy involving photothermal therapy (PPT) and magnetic hyperthermia therapy (MHT) for tumor treatment are highlighted, summarized, and extensively discussed.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100022"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000560/pdfft?md5=6f62f481cf06abdac273cd756f7bc6ed&pid=1-s2.0-S2790676023000560-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano TransMed","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2790676023000560","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Tumor immunotherapy represents an intricate approach to combat tumors by modifying the immune microenvironment within the body. Nevertheless, the limited success rate and potential induction of systemic toxic reactions associated with immunotherapy introduce uncertainty regarding its therapeutic effectiveness. Nanoparticles (NPs) exhibit multifaceted applications as therapeutic and diagnostic tools, enabling precise delivery of various immunotherapeutic agents and monitoring of tissue cellular responses. These capabilities facilitate the dynamic assessment of factors influencing immune activity, thereby optimizing future treatment strategies. The utilization of multimodal anti-tumor therapies has paved the way for the induction of potent immune responses, while simultaneously minimizing adverse effects and facilitating the monitoring of immune activities.This review aims to provide an overview of this emerging field and highlight new technologies for next-generation immunotherapy. The current therapeutic approaches are introduced, and the mechanism of action of nanomaterials in combination with thermotherapy to stimulate systemic immune responses is explored. Furthermore, recent advancements in synergistic immunotherapy involving photothermal therapy (PPT) and magnetic hyperthermia therapy (MHT) for tumor treatment are highlighted, summarized, and extensively discussed.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
通过纳米材料的热效应改变免疫疗法疗效的研究进展
肿瘤免疫疗法是一种通过改变体内免疫微环境来对抗肿瘤的复杂方法。然而,免疫疗法的成功率有限,而且可能诱发全身毒性反应,这给其治疗效果带来了不确定性。纳米粒子(NPs)作为治疗和诊断工具具有多方面的应用,可精确输送各种免疫治疗药物并监测组织细胞反应。这些功能有助于对影响免疫活动的因素进行动态评估,从而优化未来的治疗策略。多模式抗肿瘤疗法的应用为诱导强效免疫反应铺平了道路,同时还能最大限度地减少不良反应并促进对免疫活动的监测。本文介绍了当前的治疗方法,并探讨了纳米材料与热疗相结合刺激全身免疫反应的作用机制。此外,还重点介绍、总结并广泛讨论了光热疗法(PPT)和磁热疗法(MHT)用于肿瘤治疗的协同免疫疗法的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Association and enterprise standard for producing and monitoring of quality extracellular vesicles /exosomes derived from human mesenchymal stem cells Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death Biogenic silver nanoparticles from Simarouba glauca DC leaf extract: Synthesis, characterization, and anticancer efficacy in lung cancer cells with protective effects in Caenorhabditis elegans Phytomedicine meets nanotechnology: A cellular approach to rheumatoid arthritis treatment Exosomes for skin treatment: Therapeutic and cosmetic applications
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1