Nano TransMed最新文献

英文中文

Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats

Nano TransMed

Pub Date : 2025-01-28 DOI: 10.1016/j.ntm.2025.100074

Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Marwa Kechnebbou , Salem Amara

The brain has natural antioxidant defense systems, functioning through enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase, which neutralize reactive oxygen species (ROS). Once these defense systems are overwhelmed by poisoning, oxidative damage can occur in the brain. In this study, hydrogen peroxide (H₂O₂) was used to induce oxidative stress. Ascorbic acid grafted to silica nanoparticles (SiO₂-NPs@AA) was used as a therapeutic strategy aimed to reduce ROS levels and enhancing antioxidant defenses. The SiO₂-NPs@AA were synthesized and characterized, showing efficient functionalization with ascorbic acid. The in-vitro, antioxidant assays revealed that SiO₂-NPs@AA exhibited significant radical scavenging activity (DPPH and hydroxyl radicals) and high iron-chelating ability with enhanced stability compared to free ascorbic acid. Moreover, the in-vivo study demonstrated that SiO₂-NPs@AA mitigated H₂O₂-induced effects in key enzymes, including superoxide dismutase, catalase, glutathione (GSH), and restore acetylcholinesterase (AChE) levels. Notably, malondialdehyde (MDA) levels, a marker of lipid peroxidation, were significantly reestablished in the frontal cortex and hippocampus following SiO₂-NPs@AA. Overall, the study revealed that SiO₂-NPs@AA corrected effectively nitric oxide (NO) and monoamine oxidase activities, which confirm their role to preserve neuronal function and mitigate neurotoxicity.

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引用次数: 0

Erratum regarding previously published articles

Nano TransMed

Pub Date : 2025-01-22 DOI: 10.1016/j.ntm.2025.100072

引用次数: 0

Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics

Nano TransMed

Pub Date : 2025-01-22 DOI: 10.1016/j.ntm.2025.100073

D. Mahalakshmi , J. Nandhini , G. Meenaloshini , E. Karthikeyan , KK Karthik , J. Sujaritha , Vandhana V , C. Ragavendran

Graphene-based electrochemical biosensors have emerged as promising tools for the early detection and monitoring of oral cancer through salivary biomarker analysis. Graphene's exceptional properties, including high surface area, superior electrical conductivity, and excellent mechanical strength, enable the development of highly sensitive and specific biosensors. This review provides a comprehensive overview of the current state-of-the-art in graphene-based electrochemical biosensors for salivary biomarker detection in oral cancer. We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. The challenges associated with the development and clinical translation of these biosensors are also addressed, emphasizing the need for improved functionalization strategies, enhanced stability, and standardized validation protocols. Finally, we present a futuristic outlook on the integration of graphene-based biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable personalized diagnostics and treatment monitoring. With continued advancements in sensor technology and computational tools, graphene-based electrochemical biosensors have the potential to revolutionize oral cancer management, improving patient outcomes and quality of life.

{"title":"Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics","authors":"D. Mahalakshmi , J. Nandhini , G. Meenaloshini , E. Karthikeyan , KK Karthik , J. Sujaritha , Vandhana V , C. Ragavendran","doi":"10.1016/j.ntm.2025.100073","DOIUrl":"10.1016/j.ntm.2025.100073","url":null,"abstract":"<div><div>Graphene-based electrochemical biosensors have emerged as promising tools for the early detection and monitoring of oral cancer through salivary biomarker analysis. Graphene's exceptional properties, including high surface area, superior electrical conductivity, and excellent mechanical strength, enable the development of highly sensitive and specific biosensors. This review provides a comprehensive overview of the current state-of-the-art in graphene-based electrochemical biosensors for salivary biomarker detection in oral cancer. We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. The challenges associated with the development and clinical translation of these biosensors are also addressed, emphasizing the need for improved functionalization strategies, enhanced stability, and standardized validation protocols. Finally, we present a futuristic outlook on the integration of graphene-based biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable personalized diagnostics and treatment monitoring. With continued advancements in sensor technology and computational tools, graphene-based electrochemical biosensors have the potential to revolutionize oral cancer management, improving patient outcomes and quality of life.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers

Nano TransMed

Pub Date : 2025-01-16 DOI: 10.1016/j.ntm.2025.100071

Nobendu Mukerjee , Dattatreya Mukherjee

The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant morbidity and lack specificity in targeting the molecular pathogenesis of the disease. Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies.

引用次数: 0

Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract

Nano TransMed

Pub Date : 2025-01-09 DOI: 10.1016/j.ntm.2025.100070

Megha B. Abbigeri , Bothe Thokchom , Sapam Riches Singh , Santosh Mallikarjun Bhavi , B.P. Harini , Ramesh Babu Yarajarla

The weed Martynia annua traditionally known as Kakanasika is annual herbaceous plant known for its multiple medicinal properties such as anthelmintic, analgesic, antipyretic, antibacterial, anti-convulsant, anti-fertility, antinociceptive, antioxidant, CNS depressant and wound healing activity. The aqueous root extract of M. annua was subjected to qualitative analysis, revealing the presence of terpeniods, indicative of its rich phytochemicals composition. Utilizing a green synthesis approach, silver nanoparticles (AgNPs) were successfully synthesized from the plant extract. Characterization through UV-Visible spectroscopy, FTIR, DLS, and SEM/EDX confirmed the formation of AgNPs with polygonal morphology and an average size of 64 nm, with the PDI of 0.385. Additionally, the AgNPs demonstrated moderate stability, evidenced by a zeta potential of −21.6 mV. Evaluation of the synthesized AgNPs focused on their anti-diabetic potential. The green synthesized R-AgNPs were potent antioxidant agents. They exhibited significant inhibition of alpha amylase, a pivotal enzyme in carbohydrate metabolism, suggesting their efficacy as anti-diabetic agents. Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. This study highlights the pharmacological importance of M.annua, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. Further investigation into the mechanism of action and clinical efficacy of these AgNPs in diabetes management is warranted.

{"title":"Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract","authors":"Megha B. Abbigeri , Bothe Thokchom , Sapam Riches Singh , Santosh Mallikarjun Bhavi , B.P. Harini , Ramesh Babu Yarajarla","doi":"10.1016/j.ntm.2025.100070","DOIUrl":"10.1016/j.ntm.2025.100070","url":null,"abstract":"<div><div>The weed <em>Martynia annua</em> traditionally known as Kakanasika is annual herbaceous plant known for its multiple medicinal properties such as anthelmintic, analgesic, antipyretic, antibacterial, anti-convulsant, anti-fertility, antinociceptive, antioxidant, CNS depressant and wound healing activity. The aqueous root extract of <em>M. annua</em> was subjected to qualitative analysis, revealing the presence of terpeniods, indicative of its rich phytochemicals composition. Utilizing a green synthesis approach, silver nanoparticles (AgNPs) were successfully synthesized from the plant extract. Characterization through UV-Visible spectroscopy, FTIR, DLS, and SEM/EDX confirmed the formation of AgNPs with polygonal morphology and an average size of 64 nm, with the PDI of 0.385. Additionally, the AgNPs demonstrated moderate stability, evidenced by a zeta potential of −21.6 mV. Evaluation of the synthesized AgNPs focused on their anti-diabetic potential. The green synthesized R-AgNPs were potent antioxidant agents. They exhibited significant inhibition of alpha amylase, a pivotal enzyme in carbohydrate metabolism, suggesting their efficacy as anti-diabetic agents. Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. This study highlights the pharmacological importance of <em>M.annua</em>, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. Further investigation into the mechanism of action and clinical efficacy of these AgNPs in diabetes management is warranted.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocarriers in skin cancer treatment: Emerging drug delivery approaches and innovations

Nano TransMed

Pub Date : 2024-12-17 DOI: 10.1016/j.ntm.2024.100068

Laxmi A. Jadhav, Satish K. Mandlik

Background

Skin cancer is a growing global health issue, with rising incidence rates, particularly among Caucasian populations. It is the most common malignancy, contributing significantly to mortality and decreased quality of life worldwide. While surgical interventions remain the primary treatment, there is a pressing need for innovative strategies to reduce the morbidity and mortality associated with the disease. As the burden of skin cancer continues to grow, the medical community is increasingly exploring novel therapeutic approaches to improve patient outcomes.

Main body

Nanotechnology has introduced new possibilities for treating skin cancer, offering advantages in targeted drug delivery, advanced imaging, and diagnostics. Nanomaterials are especially useful in dermatology, as they enhance the penetration and retention of therapeutic agents while minimizing side effects. Various nanomaterials have been studied for their potential in treating skin disorders, including cancer. This review examines the role of nanotechnology in skin cancer treatment, focusing on the development and design of nanocarriers for the precise delivery of drugs. We also discuss the advantages of nanotechnology over traditional treatments, such as improved bioavailability and targeted action. Additionally, we explore clinical trials, patents and FDA approved products related to nanocarrier-based treatments for cancer and skin cancer, highlighting advancements in the field.

Conclusion

Nanotechnology holds significant promise in revolutionizing skin cancer treatment. As research progresses, it is expected that more effective, personalized therapies will emerge, ultimately improving patient outcomes. Integrating nanotechnology into clinical practice could elevate the standard of care, offering new hope in managing skin cancer.

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引用次数: 0

Nano delivery systems in stem cell therapy: Transforming regenerative medicine and overcoming clinical challenges

Nano TransMed

Pub Date : 2024-12-15 DOI: 10.1016/j.ntm.2024.100069

Aswini Rajendran, Rithi Angelin Rajan, Saranya Balasubramaniyam, Karthikeyan Elumalai

Stem cell therapy has emerged as a promising approach in regenerative medicine, offering potential treatments for various degenerative diseases and injuries. However, the clinical application of stem cell therapy faces challenges such as low cell viability, inefficient delivery to target sites, and immune rejection. Nanodelivery systems (NDS) have the potential to address these limitations and enhance the efficacy of stem cell-based treatments. This review looks at how NDS can help stem cell therapy work well by creating a safe environment, allowing targeted delivery, and making it easier to control the release of therapeutic factors. The article discusses various types of NDS, including liposomes, polymeric nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, and magnetic nanoparticles, highlighting their unique properties and advantages in stem cell therapy applications. Furthermore, the review examines the potential of NDS in specific areas of regenerative medicine, such as cardiovascular regeneration, neurodegenerative diseases, musculoskeletal tissue repair, and wound healing. The article also addresses the challenges and limitations associated with NDS, such as biocompatibility, toxicity, manufacturing scalability, and regulatory hurdles. Finally, the article explores the future trajectory of nanotechnology in stem cell therapy, discussing the utilization of intelligent nanoparticles, precision genetic modifications, and the benefits of personalized nanomedicine.

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引用次数: 0

Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100049

Vinotha Mani , Keerthana Shrri Gopinath , Nithya Varadharaju , Dapkupar Wankhar , Arjunan Annavi

Background

Integrating nanomedicines for targeted cancer treatment and pursuing medicinally valuable components from nature are crucial for sustainable, potent alternatives to synthetic drugs in combating fatal diseases like cancer. Hence, a green synthesis of nickel oxide (NiO NPs) and zinc oxide nanoparticles (ZnO NPs) has been carried out by using the leaf extract of medicinally important plant Abutilonindicum. This sustainable approach to medical developments not only reduces the environmental effect of standard synthesis methods and offers new options for novel cancer therapeutics, but it also advances public health by using natural resources in a sustainable manner.

Methods

The synthesized nanoparticles were characterized by employing spectro-analytical techniques like UV–vis, FT-IR, SEM and powder XRD. Synthesized nanparticles were evaluated in the human cervical cancer cells (HeLa).

Results

Ni-O stretching vibrations were observed at 402 cm⁻¹, whereas that of Zn-O stretching was observed at 409 cm⁻¹in the FT-IR spectrum, confirming the formation of nanoparticles. The XRD pattern revealed the crystallite size range of 1.35–2.84 nm for NiO NPs and 7.71–56.80 nm for ZnO NPs. The morphology of the nanoparticles, as indicated by the SEM images, was rod-like for NiO NPs and rock-shaped for ZnO NPs. Further, the cancer cell growth inhibition activity of the nanoparticles was examined by MTT assay against human cervical cancer cells (HeLa) proliferation and compared with cisplatin. MTT assay elucidated the significant anticancer efficacy of the synthesized nanoparticles, showcasing low IC₅₀ values of 29±0.5 µg/ml for NiO NPs and 32±0.7 µg/ml for ZnO NPs. Furthermore, the anticancer activity of the NiO NPs was investigated using the Trypan blue dye exclusion technique, emphasizing the pronounced cytotoxic impact of NiO NPs on cancer cell viability. The outcomes underscore the notable anticancer properties of plant extract mediated metal nanoparticles as promising contenders for advancing cancer treatment modalities.

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引用次数: 0

Nanoindentation: Introduction and applications of a non-destructive analysis

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100057

Zaid H. Mahmoud , H.N.K. AL-Salman , Ehsan Kianfar

Nanoindentation test is known as a powerful method for non-destructive characterization and analysis of mechanical properties of nanoscale materials. In this method, the indenting tip penetrates the surface of the sample by applying a force of several millinewtons to the extent of several nanometers, and the resulting force-displacement curve is used as the output of the test to calculate the mechanical characteristics of the sample, including hardness and elastic modulus, as well as to identify various mechanical phenomena such as Creep, strain hardening, surface cracking, phase transformations, creep and fracture toughness of the material are used. In this article, the Nanoindentation method is briefly introduced and its principles and basics are discussed. The application of this method is valid for analyzing the mechanical properties of a wide range of materials. The purpose of this article is to familiarize researchers and experts in engineering fields with the nanoindentation method as a non-destructive analysis and its effective use in their respective fields of application.

引用次数: 0

Nanotechnology-based advancements for effective delivery of phytoconstituents for Ocular diseases

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100056

Venkateshwaran Krishnaswami , Dhilin Pathayappurakkal Mohanan , S.A. Jacob Raja , Balakrishnan Natarajan , Shankarananth Velusamy

Phytomedicines has been globally utilized in ancient times. Phytoconstituents such as flavonoids, glycosides, peptides, carbohydrates, lipids, alkaloids, tannins, and terpenoids are holding medicinal properties. Previous reports have documented the various therapeutic activities of plant extracts/isolated fractions/pure phytoconstituents especially at in vitro levels. But the relevance towards the in vivo level and upmost towards the clinical trials for these phytomedicines was facing numerous challenges in the current scenario. The challenges associated with phytomedicines are standardization issues, ineffective against serious ailments, poor reproducibility of biological activities and interferences with associated phytoconstituents. But recently nanoscale based phytomedicine is paving more interest towards the scientific community for ocular delivery. In order to overcome these issues the nanoscale base phytomedicines delivery systems are recently developed by researchers. Nanoscale delivery systems of various phytoconstituents may potentiate the therapeutic effect, improves the bioavailability, reduces adverse effects and decreases the effective dose. The scope of this paper will focus towards the nanotechnology based phytomedicine delivery systems for various therapeutic applications in eye. The various phytomedicine loaded nanoscale delivery systems such as nanoparticles, nanomicelles, nanodispersions, lipid based nanoparticles for various ocular diseases has been reviewed. Special focus has been emphasized towards the carriers utilized for those delivery systems. Additionally, the future perspectives relating to development of novel phytomedicine based nano formulations has been discussed.

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引用次数: 0

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