Preparation and application of amphiphilic polymer nanomaterials for ischemic injury

IF 0.7 4区材料科学 Q3 Materials Science Materials Express Pub Date : 2023-12-01 DOI:10.1166/mex.2023.2557

Jiayu Li, Yili Xu

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Abstract

With the increasing popularity of competitive sports, martial arts routines have attracted great attention. However, myocardial ischemic injury is one of the most common sports-related diseases in martial arts routines. In this study, γ-Fe2O3 nanoparticles were used as a treatment for myocardial injury. The safety of these nanoparticles was determined by assessing apoptosis rates and reactive oxygen species levels in myocardial cells, as well as biochemical indicators such as lactate dehydrogenase and superoxide dismutase. The results showed that the aforementioned indicators were normal, indicating that γ-Fe2O3 nanoparticles are safe for myocardial cells. Additionally, the application of γ-Fe2O3 nanoparticles to hypoxic environments significantly improved anti-hypoxia ability, alleviated calcium overload in myocardial cells, and reduced intracellular reactive oxygen species content, thereby protecting myocardial cells from hypoxia damage. Therefore, this study provides an effective strategy for treating ischemic injury in martial arts athletes and establishes an experimental foundation for the clinical management of myocardial ischemic injury.

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制备和应用两亲性聚合物纳米材料治疗缺血性损伤

随着竞技体育的日益普及，武术套路受到了极大的关注。然而，心肌缺血性损伤是武术套路中最常见的运动相关疾病之一。本研究采用γ-Fe2O3纳米颗粒治疗心肌损伤。通过心肌细胞凋亡率和活性氧水平以及乳酸脱氢酶和超氧化物歧化酶等生化指标来确定纳米颗粒的安全性。结果表明，上述指标均正常，表明γ-Fe2O3纳米颗粒对心肌细胞是安全的。此外，将γ-Fe2O3纳米颗粒应用于缺氧环境中，可显著提高心肌细胞的抗缺氧能力，减轻心肌细胞钙超载，降低细胞内活性氧含量，从而保护心肌细胞免受缺氧损伤。因此，本研究为武术运动员缺血性损伤的治疗提供了有效的策略，为心肌缺血性损伤的临床管理奠定了实验基础。

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