Design of small molecules for CDK-2 inhibition in colorectal cancer based on substructure search

Uchechukwu C. Ogbodo, Sofela Salimat, Damilola S. Bodun, Toheeb A. Balogun, Damilola A. Omoboyowa
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Abstract

The global frequency of colorectal cancer motivates extensive drug discovery efforts. CDK2, a key member of the CDK family, has been linked to tumor progression, unregulated cell proliferation, and...
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基于子结构搜索设计抑制结直肠癌 CDK-2 的小分子化合物
结直肠癌的全球频率促使了广泛的药物发现工作。CDK2是CDK家族的关键成员,与肿瘤进展、不受调节的细胞增殖和…
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