High-throughput virtual screening, pharmacophore modelling and antagonist effects of small molecule inhibitors against cytotoxin-induced cytotoxicity

En Qi Lim, Nafees Ahemad, Michelle Khai Khun Yap
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Abstract

Cobra venom cytotoxins (CTX) cause dermonecrosis in envenomed patients who suffered from limb amputations due to the limitation of serotherapy-based antivenoms. This study aimed to identify small m...
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小分子抑制剂对细胞毒素诱导的细胞毒性的高通量虚拟筛选、药理模型和拮抗作用
由于基于血清疗法的抗蛇毒血清的局限性,眼镜蛇毒细胞毒素(CTX)会导致被蛇咬伤的患者肢体坏死。本研究旨在确定眼镜蛇毒细胞毒素的微小...
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