Cefiderocol: Clinical application and emergence of resistance

IF 15.8 1区 医学 Q1 PHARMACOLOGY & PHARMACY Drug Resistance Updates Pub Date : 2023-12-18 DOI:10.1016/j.drup.2023.101034
Liang Wang , Jie Zhu , Liang Chen , Hong Du
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Abstract

Antibacterial drug resistance of gram-negative bacteria (GNB) results in high morbidity and mortality of GNB infection, seriously threaten human health globally. Developing new antibiotics has become the critical need for dealing with drug-resistant bacterial infections. Cefiderocol is an iron carrier cephalosporin that achieves drug accumulation through a unique “Trojan horse” strategy into the bacterial periplasm. It shows high antibacterial activity against multidrug-resistant (MDR) Enterobacteriaceae and MDR non-fermentative bacteria. The application of cefiderocol offers new hope for treating clinical drug-resistant bacterial infections. However, limited clinical data and uncertainties about its resistance mechanisms constrain the choice of its therapeutic use. This review aimed to summarize the clinical applications, drug resistance mechanisms, and co-administration of cefiderocol.

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头孢羟氨苄:临床应用和抗药性的出现
革兰氏阴性细菌(GNB)的抗菌药耐药性导致 GNB 感染的高发病率和高死亡率,严重威胁全球人类健康。开发新型抗生素已成为应对耐药细菌感染的迫切需要。Cefiderocol 是一种铁载体头孢菌素,通过独特的 "特洛伊木马 "策略进入细菌外质实现药物蓄积。它对耐多药(MDR)肠杆菌科细菌和耐多药非发酵菌具有很高的抗菌活性。cefiderocol 的应用为治疗临床耐药细菌感染带来了新希望。然而,有限的临床数据及其耐药机制的不确定性限制了其治疗用途的选择。本综述旨在总结头孢羟氨苄的临床应用、耐药机制和联合用药。
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来源期刊
Drug Resistance Updates
Drug Resistance Updates 医学-药学
CiteScore
26.20
自引率
11.90%
发文量
32
审稿时长
29 days
期刊介绍: Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research
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