Endotoxin biomarkers, hepatic fat fraction, liver volume and liver stiffness among adolescents at high-risk for non-alcoholic fatty liver disease: The HEROES study

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2023-12-12 DOI:10.1111/ijpo.13091

Wei Perng, Kyle Salmon, Rachel Schenker, Rachel C. Janssen, Jacob E. Friedman, Michael I. Goran

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Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is on the rise among youth. Identifying biomarkers of NAFLD progression/risk can aid in prevention efforts.

Aims

This pilot study investigated associations of two endotoxin biomarkers—lipopolysaccharide-binding protein (LBP) and anti-endotoxin core immunoglobulin G (EndoCab)—with markers of NAFLD among 99 Latino/Latina adolescents (11–19 years) with obesity.

Materials & Methods

We used linear regression to examine associations of each endotoxin biomarker (per 1-SD) with hepatic fat fraction (HFF), liver volume, and liver stiffness.

Results

We found positive associations of LBP with HFF and liver volume. Each 1-SD increment in LBP corresponded with 2.35% (95% CI: 0.46%, 4.23%) higher HFF and 0.14 (0.06, 0.23) L greater liver volume after adjusting for age, sex, and maternal education. Accounting for abdominal adiposity and Tanner stage did not change results. Excluding 72 participants with NAFLD attenuated associations of LBP with HFF but associations with liver volume persisted (0.11 [0.01, 0.21] L). EndoCab was not associated with any liver outcomes. Neither endotoxin biomarker predicted liver stiffness.

Discussion/conclusion

While additional research is warranted, our results support LBP as a biomarker of NAFLD risk/progression in high-risk youth.

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非酒精性脂肪肝高危青少年的内毒素生物标志物、肝脏脂肪率、肝脏体积和肝脏硬度：HEROES研究

背景：非酒精性脂肪肝（NAFLD）在年轻人中呈上升趋势。目的：这项试验性研究调查了99名患有肥胖症的拉丁/拉美裔青少年（11-19岁）中两种内毒素生物标志物--脂多糖结合蛋白（LBP）和抗内毒素核心免疫球蛋白G（EndoCab）--与非酒精性脂肪肝标志物的关系：我们使用线性回归法研究了每种内毒素生物标志物（每1-SD）与肝脏脂肪分数（HFF）、肝脏体积和肝脏硬度的关系：我们发现肝硬变与肝脏脂肪分数和肝脏体积呈正相关。在对年龄、性别和母亲教育程度进行调整后，LBP 每增加 1 SD，肝脏脂肪分数就会增加 2.35% (95% CI: 0.46%, 4.23%) ，肝脏体积就会增加 0.14 (0.06, 0.23) L。考虑腹部脂肪含量和坦纳阶段不会改变结果。排除 72 名患有非酒精性脂肪肝的参与者后，LBP 与 HFF 的相关性减弱，但与肝脏体积的相关性仍然存在（0.11 [0.01, 0.21] L）。EndoCab与任何肝脏结果都无关。两种内毒素生物标志物都不能预测肝脏僵化：我们的研究结果支持将肝硬变作为高危青少年非酒精性脂肪肝风险/进展的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.