Global, regional, and national disease burden and attributable risk factors of HIV/AIDS in older adults aged 70 years and above: a trend analysis based on the Global Burden of Disease study 2019.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES Epidemiology and Infection Pub Date : 2023-12-15 DOI:10.1017/S0950268823001954

Min Du, Min Liu, Jue Liu

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Abstract

We aimed to assess the burden and trend of the HIV/AIDS epidemic among older adults over the past three decades at different geographical levels, based on the data collected from the Global Burden of Diseases (GBD) study 2019. This assessment identified the average annual percentage changes (AAPCs) using Joinpoint regression analysis. Globally, the incidence of HIV/AIDS has decreased (AAPC = -3.107); however, the overall prevalence has consistently increased (AAPC = 5.557). Additionally, both mortality (AAPC = 2.166) and disability-adjusted life years (DALYs; AAPC = 2.429) have increased. The highest increasing trends in female HIV/AIDS incidence and prevalence were observed in the Central Asia region. However, for males, these trends were observed in the Oceania region and the high-income Asia Pacific region, respectively. In recent decades, females aged 70-74 years had the highest incidence and prevalence, while males aged 70-74 years had highest mortality and DALYs in low social development index (SDI) regions. Unsafe sex resulted in 15 381.16 deaths, accounting for 90.73% of all HIV/AIDS deaths, and 331 140.56 DALYs, accounting for 91.12% of all HIV/AIDS DALYs. The HIV/AIDS disease burden differs by region, age, and sex among older adults. Sexual health education and targeted screening for older adults are recommended.

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全球、地区和国家 70 岁及以上老年人感染艾滋病毒/艾滋病的疾病负担和可归因风险因素：基于 2019 年全球疾病负担研究的趋势分析。

我们的目的是根据 2019 年全球疾病负担（GBD）研究收集的数据，评估过去三十年中老年人感染艾滋病毒/艾滋病的负担和趋势。该评估采用 Joinpoint 回归分析法确定了年均百分比变化（AAPC）。在全球范围内，艾滋病毒/艾滋病发病率有所下降（AAPC = -3.107）；然而，总体流行率却持续上升（AAPC = 5.557）。此外，死亡率（AAPC = 2.166）和残疾调整寿命年数（DALYs；AAPC = 2.429）均有所上升。中亚地区女性艾滋病毒/艾滋病发病率和流行率的增长趋势最为明显。然而，就男性而言，这些趋势分别出现在大洋洲地区和高收入的亚太地区。近几十年来，在社会发展指数（SDI）较低的地区，70-74 岁女性的发病率和流行率最高，而 70-74 岁男性的死亡率和残疾调整寿命年数最高。不安全性行为导致 15 381.16 人死亡，占艾滋病毒/艾滋病死亡总人数的 90.73%，331 140.56 人残疾调整寿命年数，占艾滋病毒/艾滋病残疾调整寿命年数的 91.12%。老年人的艾滋病毒/艾滋病疾病负担因地区、年龄和性别而异。建议对老年人开展性健康教育和有针对性的筛查。

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来源期刊

Epidemiology and Infection 医学-传染病学

CiteScore

4.10

自引率

2.40%

发文量

366

审稿时长

3-6 weeks

期刊介绍： Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.