Impact of ketogenic diet on cardiovascular disease.

IF 5.9 2区医学 Q1 NUTRITION & DIETETICS Nutrition reviews Pub Date : 2024-12-01 DOI:10.1093/nutrit/nuad152

Mohamed S Zaghloul, Santiago Elizondo-Benedetto, Mohamed A Zayed

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Abstract

Objectives: A comprehensive review of the current literature was conducted to summarize the potential therapeutic and management roles of ketogenic diet (KD) for cardiovascular disease (CVD).

Background: Consensus has not been reached on the optimal diet for individuals with cardiovascular risk factors. KDs are characterized by high-fat, low-carbohydrate, and appropriate protein content, and have gained popularity in recent years in the management of various conditions, including cardiovascular and metabolic diseases.

Methods: Original research, systematic reviews, and meta-analyses available in the PubMed, Web of Science, and Google Scholar databases were reviewed.

Results: The current body of preclinical and clinical evidence on the efficacy of KD in the management of CVD remains limited. Specific applications of KD seem to suggest a positive impact on management of CVD. However, conflicting results and a lack of precise molecular and biochemical mechanisms of action provide ample opportunity for future investigation.

Conclusion: More multidisciplinary studies are needed to determine the true clinical benefit of KD in the management of CVD and so justify its expanded clinical use.

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生酮饮食对心血管疾病的影响。

目的：对现有文献进行全面回顾，总结生酮饮食（KD）对心血管疾病的潜在治疗和管理作用：对现有文献进行全面回顾，总结生酮饮食（KD）对心血管疾病（CVD）的潜在治疗和管理作用：背景：对于具有心血管风险因素的人的最佳饮食尚未达成共识。生酮饮食的特点是高脂肪、低碳水化合物和适当的蛋白质含量，近年来在治疗包括心血管疾病和代谢性疾病在内的各种疾病方面越来越受欢迎：方法：查阅了 PubMed、Web of Science 和 Google Scholar 数据库中的原始研究、系统综述和荟萃分析：结果：目前有关 KD 治疗心血管疾病疗效的临床前和临床证据仍然有限。KD的具体应用似乎对心血管疾病的治疗有积极影响。然而，相互矛盾的结果以及缺乏精确的分子和生化作用机制为未来的研究提供了充足的机会：结论：需要进行更多的多学科研究，以确定 KD 对心血管疾病治疗的真正临床益处，从而证明其扩大临床应用的合理性。

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来源期刊

Nutrition reviews 医学-营养学

CiteScore

12.20

自引率

1.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.